hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10780.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBXN11 | UBX domain-containing protein 11 (Colorectal tumor-associated antigen COA-1) (Socius) (UBX domain-containing protein 5) | 5 | UniProt NCBI |
| TMEM44 | Transmembrane protein 44 | 4 | UniProt NCBI |
| COL1A2 | Collagen alpha-2(I) chain (Alpha-2 type I collagen) | 5 | UniProt NCBI |
| LDHAL6A | L-lactate dehydrogenase A-like 6A (LDHA-like protein 6A) (EC 1.1.1.27) | 4 | UniProt NCBI |
| COL1A1 | Collagen alpha-1(I) chain (Alpha-1 type I collagen) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0003321 | 6.41370849429e-05 | 0.4 | COL1A2 COL1A1 | Biconcave flattened vertebrae |
| HP:0005005 | 6.41370849429e-05 | 0.4 | COL1A2 COL1A1 | Femoral bowing present at birth, straightening with time |
| HP:0005897 | 6.41370849429e-05 | 0.4 | COL1A2 COL1A1 | Severe generalized osteoporosis |
| HP:0005623 | 6.41370849429e-05 | 0.4 | COL1A2 COL1A1 | Absent ossification of calvaria |
| HP:0003023 | 0.000384717178033 | 0.4 | COL1A2 COL1A1 | Bowing of limbs due to multiple fractures |
| REAC:R-HSA-430116 | 0.000546723465219 | 0.4 | COL1A2 COL1A1 | GP1b-IX-V activation signalling |
| HP:0000362 | 0.000641107533884 | 0.4 | COL1A2 COL1A1 | Otosclerosis |
| HP:0005758 | 0.000641107533884 | 0.4 | COL1A2 COL1A1 | Basilar impression |
| REAC:R-HSA-75892 | 0.000683310775372 | 0.4 | COL1A2 COL1A1 | Platelet Adhesion to exposed collagen |
| HP:0006367 | 0.000961529670085 | 0.4 | COL1A2 COL1A1 | Crumpled long bones |
| REAC:R-HSA-2214320 | 0.0011839189519 | 0.4 | COL1A2 COL1A1 | Anchoring fibril formation |
| HP:0000923 | 0.001345957274 | 0.4 | COL1A2 COL1A1 | Beaded ribs |
| WP:WP453 | 0.00148385269311 | 0.4 | COL1A2 COL1A1 | Inflammatory response pathway |
| WP:WP5036 | 0.00161852668418 | 0.4 | COL1A2 COL1A1 | Angiotensin II receptor type 1 pathway |
| HP:0025019 | 0.00179436403841 | 0.4 | COL1A2 COL1A1 | Arterial rupture |
| REAC:R-HSA-2243919 | 0.0018206657072 | 0.4 | COL1A2 COL1A1 | Crosslinking of collagen fibrils |
| REAC:R-HSA-3000480 | 0.00206313859056 | 0.4 | COL1A2 COL1A1 | Scavenging by Class A Receptors |
| HP:0008921 | 0.00230672366147 | 0.4 | COL1A2 COL1A1 | Neonatal short-limb short stature |
| WP:WP4786 | 0.00272425197171 | 0.4 | COL1A2 COL1A1 | Type I collagen synthesis in the context of osteogenesis imperfecta |
| REAC:R-HSA-3000170 | 0.00350190276731 | 0.4 | COL1A2 COL1A1 | Syndecan interactions |
| HP:0031869 | 0.0035231963033 | 0.4 | COL1A2 COL1A1 | Recurrent joint dislocation |
| HP:0008628 | 0.0035231963033 | 0.4 | COL1A2 COL1A1 | Abnormality of the stapes |
| REAC:R-HSA-8874081 | 0.00418294558639 | 0.4 | COL1A2 COL1A1 | MET activates PTK2 signaling |
| HP:0003179 | 0.00422725674544 | 0.4 | COL1A2 COL1A1 | Protrusio acetabuli |
| HP:0001027 | 0.00422725674544 | 0.4 | COL1A2 COL1A1 | Soft, doughy skin |
| GO:0005584 | 0.00468200720083 | 0.4 | COL1A2 COL1A1 | collagen type I trimer |
| HP:0010547 | 0.00499516489297 | 0.4 | COL1A2 COL1A1 | Muscle flaccidity |
| REAC:R-HSA-114604 | 0.00531742996423 | 0.4 | COL1A2 COL1A1 | GPVI-mediated activation cascade |
| REAC:R-HSA-76009 | 0.00572567861867 | 0.4 | COL1A2 COL1A1 | Platelet Aggregation (Plug Formation) |
| WP:WP5144 | 0.00631928190743 | 0.4 | COL1A2 COL1A1 | NRP1 triggered signaling pathways in pancreatic cancer |
| REAC:R-HSA-8948216 | 0.0065872694687 | 0.4 | COL1A2 COL1A1 | Collagen chain trimerization |
| HP:0003834 | 0.00672241921037 | 0.4 | COL1A2 COL1A1 | Shoulder dislocation |
| REAC:R-HSA-8875878 | 0.00849065158197 | 0.4 | COL1A2 COL1A1 | MET promotes cell motility |
| HP:0005855 | 0.00870474912182 | 0.4 | COL1A2 COL1A1 | Multiple prenatal fractures |
| HP:0100541 | 0.00870474912182 | 0.4 | COL1A2 COL1A1 | Femoral hernia |
| HP:0040160 | 0.00870474912182 | 0.4 | COL1A2 COL1A1 | Generalized osteoporosis |
| HP:0005474 | 0.00870474912182 | 0.4 | COL1A2 COL1A1 | Decreased calvarial ossification |
| HP:0002691 | 0.00870474912182 | 0.4 | COL1A2 COL1A1 | Platybasia |
| REAC:R-HSA-2173782 | 0.00900400267976 | 0.4 | COL1A2 COL1A1 | Binding and Uptake of Ligands by Scavenger Receptors |
| WP:WP5055 | 0.00931707261303 | 0.4 | COL1A2 COL1A1 | Burn wound healing |
| HP:0004452 | 0.00979150178217 | 0.4 | COL1A2 COL1A1 | Abnormality of the middle ear ossicles |
| HP:0000703 | 0.00979150178217 | 0.4 | COL1A2 COL1A1 | Dentinogenesis imperfecta |
| KEGG:04512 | 0.00996128881886 | 0.4 | COL1A2 COL1A1 | ECM-receptor interaction |
| KEGG:04974 | 0.0105666091545 | 0.4 | COL1A2 COL1A1 | Protein digestion and absorption |
| HP:0010299 | 0.0121560512731 | 0.4 | COL1A2 COL1A1 | Abnormal dentin morphology |
| HP:0010648 | 0.0161800923797 | 0.4 | COL1A2 COL1A1 | Dermal translucency |
| HP:0010444 | 0.0161800923797 | 0.4 | COL1A2 COL1A1 | Pulmonary insufficiency |
| REAC:R-HSA-2022090 | 0.0163316506439 | 0.4 | COL1A2 COL1A1 | Assembly of collagen fibrils and other multimeric structures |
| KEGG:05146 | 0.0164241113683 | 0.4 | COL1A2 COL1A1 | Amoebiasis |
| KEGG:04933 | 0.0168082536599 | 0.4 | COL1A2 COL1A1 | AGE-RAGE signaling pathway in diabetic complications |
| REAC:R-HSA-3000171 | 0.0170393864121 | 0.4 | COL1A2 COL1A1 | Non-integrin membrane-ECM interactions |
| HP:0004586 | 0.0176485923371 | 0.4 | COL1A2 COL1A1 | Biconcave vertebral bodies |
| REAC:R-HSA-1442490 | 0.0177620315324 | 0.4 | COL1A2 COL1A1 | Collagen degradation |
| REAC:R-HSA-1650814 | 0.0200193611976 | 0.4 | COL1A2 COL1A1 | Collagen biosynthesis and modifying enzymes |
| HP:0008609 | 0.0207761643339 | 0.4 | COL1A2 COL1A1 | Abnormal middle ear morphology |
| HP:0001591 | 0.0207761643339 | 0.4 | COL1A2 COL1A1 | Bell-shaped thorax |
| KEGG:04611 | 0.0213229262457 | 0.4 | COL1A2 COL1A1 | Platelet activation |
| HP:0032153 | 0.0224351839587 | 0.4 | COL1A2 COL1A1 | Joint subluxation |
| HP:0002982 | 0.0241576577336 | 0.4 | COL1A2 COL1A1 | Tibial bowing |
| HP:0005743 | 0.0241576577336 | 0.4 | COL1A2 COL1A1 | Avascular necrosis of the capital femoral epiphysis |
| REAC:R-HSA-3000178 | 0.0249357389386 | 0.4 | COL1A2 COL1A1 | ECM proteoglycans |
| KEGG:04926 | 0.0258857078716 | 0.4 | COL1A2 COL1A1 | Relaxin signaling pathway |
| REAC:R-HSA-216083 | 0.0294410858888 | 0.4 | COL1A2 COL1A1 | Integrin cell surface interactions |
| HP:0001030 | 0.0297055420477 | 0.4 | COL1A2 COL1A1 | Fragile skin |
| HP:0000015 | 0.0337209222644 | 0.4 | COL1A2 COL1A1 | Bladder diverticulum |
| HP:0001075 | 0.0337209222644 | 0.4 | COL1A2 COL1A1 | Atrophic scars |
| REAC:R-HSA-6806834 | 0.035336387757 | 0.4 | COL1A2 COL1A1 | Signaling by MET |
| HP:0000977 | 0.0358235710582 | 0.4 | COL1A2 COL1A1 | Soft skin |
| REAC:R-HSA-1474290 | 0.0384836492499 | 0.4 | COL1A2 COL1A1 | Collagen formation |
| HP:0006094 | 0.0425110382594 | 0.4 | COL1A2 COL1A1 | Finger joint hypermobility |
| HP:0001058 | 0.0425110382594 | 0.4 | COL1A2 COL1A1 | Poor wound healing |
| HP:0004331 | 0.0425110382594 | 0.4 | COL1A2 COL1A1 | Decreased skull ossification |
| HP:0100323 | 0.0448666137641 | 0.4 | COL1A2 COL1A1 | Juvenile aseptic necrosis |
| HP:0002980 | 0.0448666137641 | 0.4 | COL1A2 COL1A1 | Femoral bowing |
| HP:0010529 | 0.0472853555832 | 0.4 | COL1A2 COL1A1 | Echolalia |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| COL1A1 | COL1A2 | 0.998 | 0.616 | bioplex_WMM bioplex3_WMM boldt boldt_WMM treiber_WMM WMM_only |
| LDHAL6A | TMEM44 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TMEM44 | COL1A2 | 0.984 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| UBXN11 | COL1A1 | 0.972 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TMEM44 | COL1A1 | 0.972 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LDHAL6A | COL1A2 | 0.22 | bioplex3_WMM WMM_only | |
| LDHAL6A | COL1A1 | 0.074 | bioplex3_WMM WMM_only |
Related Complexes