hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10801.1

Complex Portal: CPX-14345

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
AXIN2	Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin)	5	UniProt NCBI
GSKIP	GSK3B-interacting protein (GSKIP) (GSK3beta interaction protein)	5	UniProt NCBI
GSK3A	Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)	5	UniProt NCBI
FRAT2	GSK-3-binding protein FRAT2 (Frequently rearranged in advanced T-cell lymphomas 2) (FRAT-2)	3	UniProt NCBI
GSK3B	Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)	5	UniProt NCBI
FRAT1	Proto-oncogene FRAT1 (Frequently rearranged in advanced T-cell lymphomas 1) (FRAT-1)	5	UniProt NCBI
RILPL2	RILP-like protein 2 (Rab-interacting lysosomal protein-like 2) (p40phox-binding protein)	5	UniProt NCBI
AXIN1	Axin-1 (Axis inhibition protein 1) (hAxin)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-196299	1.86009193219e-08	0.5	FRAT2 GSK3B AXIN1 FRAT1	Beta-catenin phosphorylation cascade
WP:WP4258	2.63612217757e-08	0.625	FRAT2 FRAT1 AXIN2 AXIN1 GSK3B	lncRNA in canonical Wnt signaling and colorectal cancer
GO:0060070	4.0843531464e-08	0.875	GSKIP GSK3B GSK3A AXIN1 FRAT1 FRAT2 AXIN2	canonical Wnt signaling pathway
KEGG:05224	1.24295110103e-07	0.625	FRAT2 FRAT1 AXIN2 AXIN1 GSK3B	Breast cancer
KEGG:05226	1.45399109258e-07	0.625	FRAT2 FRAT1 AXIN2 AXIN1 GSK3B	Gastric cancer
REAC:R-HSA-4641262	2.45161444024e-07	0.5	FRAT2 GSK3B AXIN1 FRAT1	Disassembly of the destruction complex and recruitment of AXIN to the membrane
KEGG:04310	2.88091676092e-07	0.625	FRAT2 FRAT1 AXIN2 AXIN1 GSK3B	Wnt signaling pathway
WP:WP4262	2.89310891288e-07	0.625	FRAT2 FRAT1 AXIN2 AXIN1 GSK3B	Breast cancer pathway
GO:0016055	3.82554552541e-07	0.875	GSKIP GSK3B GSK3A AXIN1 FRAT1 FRAT2 AXIN2	Wnt signaling pathway
KEGG:05225	3.86417821983e-07	0.625	FRAT2 FRAT1 AXIN2 AXIN1 GSK3B	Hepatocellular carcinoma
GO:0198738	4.22240102813e-07	0.875	GSKIP GSK3B GSK3A AXIN1 FRAT1 FRAT2 AXIN2	cell-cell signaling by wnt
WP:WP363	4.96305994219e-07	0.5	GSK3A GSK3B AXIN1 FRAT1	Wnt signaling pathway
GO:0030877	6.06890408176e-07	0.5	GSK3A AXIN2 AXIN1 GSK3B	beta-catenin destruction complex
GO:0060828	2.69496671429e-06	0.75	GSKIP GSK3B GSK3A AXIN1 FRAT1 AXIN2	regulation of canonical Wnt signaling pathway
WP:WP4872	3.56530254203e-06	0.375	FRAT1 GSK3B AXIN1	MAP3K1 role in promoting and blocking gonadal determination
WP:WP4336	3.80843066597e-06	0.5	FRAT2 GSK3B AXIN1 FRAT1	ncRNAs involved in Wnt signaling in hepatocellular carcinoma
WP:WP2059	4.64427187123e-06	0.625	FRAT2 FRAT1 AXIN2 AXIN1 GSK3B	Alzheimer 39 s disease and miRNA effects
WP:WP5124	4.64427187123e-06	0.625	FRAT2 FRAT1 AXIN2 AXIN1 GSK3B	Alzheimer 39 s disease
REAC:R-HSA-201681	6.25196251181e-06	0.625	FRAT2 FRAT1 AXIN2 AXIN1 GSK3B	TCF dependent signaling in response to WNT
WP:WP399	1.00491852039e-05	0.5	FRAT1 AXIN2 AXIN1 GSK3B	Wnt signaling pathway and pluripotency
REAC:R-HSA-195253	1.28215875769e-05	0.5	FRAT2 GSK3B AXIN1 FRAT1	Degradation of beta-catenin by the destruction complex
WP:WP428	1.34339772658e-05	0.5	FRAT2 GSK3B AXIN1 FRAT1	Wnt signaling
GO:0030111	1.52540288285e-05	0.75	GSKIP GSK3B GSK3A AXIN1 FRAT1 AXIN2	regulation of Wnt signaling pathway
KEGG:05010	1.73213042512e-05	0.625	FRAT2 FRAT1 AXIN2 AXIN1 GSK3B	Alzheimer disease
GO:1904886	2.15253635486e-05	0.375	FRAT2 GSK3B FRAT1	beta-catenin destruction complex disassembly
CORUM:7128	2.39226645298e-05	0.25	GSKIP GSK3B	GSKIP-GSK3B-PRKAR2A complex
CORUM:7127	2.39226645298e-05	0.25	GSKIP GSK3B	GSKIP-GSK3B-PRKAR2A complex
REAC:R-HSA-195721	3.79843925063e-05	0.625	FRAT2 FRAT1 AXIN2 AXIN1 GSK3B	Signaling by WNT
KEGG:05022	4.60126953817e-05	0.625	FRAT2 FRAT1 AXIN2 AXIN1 GSK3B	Pathways of neurodegeneration - multiple diseases
KEGG:05200	6.65080913942e-05	0.625	FRAT2 FRAT1 AXIN2 AXIN1 GSK3B	Pathways in cancer
CORUM:3166	7.17483486175e-05	0.25	GSK3B AXIN1	AXIN1-APC-CTNNB1-GSK3B complex
CORUM:6352	7.17483486175e-05	0.25	GSK3B AXIN1	FoxM1-Axin-GSK3beta complex
CORUM:6353	7.17483486175e-05	0.25	GSK3B AXIN1	beta-Catenin destruction complex
CORUM:6963	7.17483486175e-05	0.25	GSK3B AXIN1	AXIN1-GID8-GSK3B complex
CORUM:7130	7.17483486175e-05	0.25	GSKIP GSK3B	PRKAR2A-GSKIP-GSK3B-DNM1L complex
KEGG:05213	0.000116307002573	0.375	AXIN2 AXIN1 GSK3B	Endometrial cancer
KEGG:05217	0.000137962042636	0.375	AXIN2 AXIN1 GSK3B	Basal cell carcinoma
CORUM:4151	0.000143457417375	0.25	GSK3B AXIN1	TSC (TSC1, TSC2, AXIN, GSK3) complex
CORUM:2998	0.000143457417375	0.25	GSK3B AXIN1	Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex
CORUM:7159	0.000143457417375	0.25	GSK3B AXIN1	TSC2-GSK3-AXIN-DVL complex
WP:WP4155	0.000283445979884	0.375	AXIN2 AXIN1 GSK3B	Endometrial cancer
KEGG:05210	0.000397700652008	0.375	AXIN2 AXIN1 GSK3B	Colorectal cancer
WP:WP4216	0.00046287066695	0.375	AXIN2 AXIN1 GSK3B	Chromosomal and microsatellite instability in colorectal cancer
WP:WP2064	0.000625219299609	0.375	AXIN2 AXIN1 GSK3B	Neural crest differentiation
KEGG:04550	0.00145234226842	0.375	AXIN2 AXIN1 GSK3B	Signaling pathways regulating pluripotency of stem cells
WP:WP710	0.00159618281405	0.375	FRAT1 GSK3B AXIN1	DNA damage response only ATM dependent
KEGG:04934	0.00164110254365	0.375	AXIN2 AXIN1 GSK3B	Cushing syndrome
GO:0007267	0.00164672421301	0.875	GSKIP GSK3B GSK3A AXIN1 FRAT1 FRAT2 AXIN2	cell-cell signaling
GO:0032436	0.00166453822603	0.5	GSK3A AXIN2 AXIN1 GSK3B	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
REAC:R-HSA-9683610	0.00200443712543	0.25	GSK3A GSK3B	Maturation of nucleoprotein
WP:WP5087	0.00243275441359	0.5	FRAT2 GSK3B AXIN1 FRAT1	Pleural mesothelioma
KEGG:04390	0.00260993521755	0.375	AXIN2 AXIN1 GSK3B	Hippo signaling pathway
WP:WP3664	0.00285973689486	0.25	GSK3B AXIN1	Regulation of Wnt B catenin signaling by small molecule compounds
GO:2000060	0.00349206859402	0.5	GSK3A AXIN2 AXIN1 GSK3B	positive regulation of ubiquitin-dependent protein catabolic process
WP:WP3872	0.00407177869695	0.25	GSK3A GSK3B	Regulation of apoptosis by parathyroid hormone related protein
REAC:R-HSA-9694631	0.00433819320746	0.25	GSK3A GSK3B	Maturation of nucleoprotein
REAC:R-HSA-198323	0.00433819320746	0.25	GSK3A GSK3B	AKT phosphorylates targets in the cytosol
GO:1901800	0.00461836161062	0.5	GSK3A AXIN2 AXIN1 GSK3B	positive regulation of proteasomal protein catabolic process
GO:0090090	0.00504805624577	0.5	GSK3A AXIN2 AXIN1 GSK3B	negative regulation of canonical Wnt signaling pathway
REAC:R-HSA-5467340	0.00505983974502	0.25	GSK3B AXIN1	AXIN missense mutants destabilize the destruction complex
REAC:R-HSA-5467348	0.00505983974502	0.25	GSK3B AXIN1	Truncations of AMER1 destabilize the destruction complex
REAC:R-HSA-4839748	0.00505983974502	0.25	GSK3B AXIN1	Signaling by AMER1 mutants
REAC:R-HSA-4839744	0.00505983974502	0.25	GSK3B AXIN1	Signaling by APC mutants
REAC:R-HSA-5467337	0.00505983974502	0.25	GSK3B AXIN1	APC truncation mutants have impaired AXIN binding
REAC:R-HSA-4839735	0.00505983974502	0.25	GSK3B AXIN1	Signaling by AXIN mutants
WP:WP2583	0.0054959559122	0.25	GSK3A GSK3B	T cell receptor and co stimulatory signaling
REAC:R-HSA-5339716	0.00583667819665	0.25	GSK3B AXIN1	Signaling by GSK3beta mutants
REAC:R-HSA-5358747	0.00583667819665	0.25	GSK3B AXIN1	CTNNB1 S33 mutants aren't phosphorylated
REAC:R-HSA-5358749	0.00583667819665	0.25	GSK3B AXIN1	CTNNB1 S37 mutants aren't phosphorylated
REAC:R-HSA-5358751	0.00583667819665	0.25	GSK3B AXIN1	CTNNB1 S45 mutants aren't phosphorylated
REAC:R-HSA-5358752	0.00583667819665	0.25	GSK3B AXIN1	CTNNB1 T41 mutants aren't phosphorylated
REAC:R-HSA-4839743	0.00583667819665	0.25	GSK3B AXIN1	Signaling by CTNNB1 phospho-site mutants
WP:WP3658	0.00656300097601	0.25	AXIN2 GSK3B	Wnt beta catenin signaling pathway in leukemia
GO:0046825	0.00824905178996	0.375	FRAT2 GSK3B FRAT1	regulation of protein export from nucleus
GO:1903052	0.00861152862574	0.5	GSK3A AXIN2 AXIN1 GSK3B	positive regulation of proteolysis involved in protein catabolic process
GO:0032434	0.00964797417951	0.5	GSK3A AXIN2 AXIN1 GSK3B	regulation of proteasomal ubiquitin-dependent protein catabolic process
WP:WP4844	0.0103268762936	0.25	GSK3B AXIN1	Influence of laminopathies on Wnt signaling
WP:WP127	0.0110360515043	0.25	GSK3A GSK3B	IL 5 signaling pathway
GO:0030178	0.012426913615	0.5	GSK3A AXIN2 AXIN1 GSK3B	negative regulation of Wnt signaling pathway
GO:2000077	0.0131096201623	0.25	GSK3A GSK3B	negative regulation of type B pancreatic cell development
WP:WP500	0.0157805174951	0.25	GSK3A GSK3B	Glycogen synthesis and degradation
REAC:R-HSA-5674400	0.0166306183768	0.25	GSK3A GSK3B	Constitutive Signaling by AKT1 E17K in Cancer
REAC:R-HSA-9683701	0.0180115696713	0.25	GSK3A GSK3B	Translation of Structural Proteins
KEGG:05165	0.0207258251199	0.375	AXIN2 AXIN1 GSK3B	Human papillomavirus infection
GO:2000058	0.0229851818624	0.5	GSK3A AXIN2 AXIN1 GSK3B	regulation of ubiquitin-dependent protein catabolic process
WP:WP4879	0.0255436500108	0.25	GSK3B AXIN1	Overlap between signal transduction pathways contributing to LMNA laminopathies
REAC:R-HSA-4791275	0.02920582473	0.25	GSK3B AXIN1	Signaling by WNT in cancer
REAC:R-HSA-162582	0.0324681032361	0.75	GSK3B GSK3A AXIN1 FRAT2 FRAT1 AXIN2	Signal Transduction
GO:0061136	0.0391228062182	0.5	GSK3A AXIN2 AXIN1 GSK3B	regulation of proteasomal protein catabolic process
GO:2000466	0.0393180950424	0.25	GSK3A GSK3B	negative regulation of glycogen (starch) synthase activity
WP:WP3680	0.0402976114103	0.25	GSK3B AXIN1	Physico chemical features and toxicity associated pathways
WP:WP5158	0.0402976114103	0.25	GSK3A GSK3B	Urotensin II mediated signaling pathway
GO:0045732	0.0445000722229	0.5	GSK3A AXIN2 AXIN1 GSK3B	positive regulation of protein catabolic process
HPA:0090162	0.0473766132884	0.875	GSKIP RILPL2 GSK3B GSK3A AXIN1 FRAT1 AXIN2	cerebellum; Purkinje cells[>=Medium]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
GSK3A	GSK3B	1.0	0.196		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM fraction
GSK3A	FRAT1	0.999		structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116
FRAT2	RILPL2	0.999			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
GSKIP	GSK3A	0.999	0.09	structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
GSK3A	AXIN1	0.998	0.23		hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116
GSK3A	FRAT2	0.997		structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
GSKIP	GSK3B	0.997	0.136		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
AXIN2	GSK3A	0.997			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
GSK3B	FRAT2	0.996			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
GSK3B	AXIN1	0.995	0.256		hein_WMM bioplex3_WMM hein () gupta_WMM
AXIN2	GSK3B	0.992			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
GSK3B	FRAT1	0.992			hein_WMM bioplex3_WMM hein ()
FRAT1	AXIN1	0.946			bioplex3_WMM WMM_only
AXIN2	FRAT1	0.946			bioplex3_WMM WMM_only
AXIN2	AXIN1	0.946			bioplex3_WMM WMM_only
GSK3A	RILPL2	0.874	0.106		bioplex3_WMM WMM_only
GSKIP	FRAT1	0.792		mutually_exclusive (P49840)	bioplex3_WMM WMM_only
GSKIP	AXIN1	0.757	0.212		bioplex3_WMM WMM_only
GSK3B	RILPL2	0.74	0.038		bioplex3_WMM WMM_only
AXIN2	GSKIP	0.466			bioplex3_WMM WMM_only
AXIN2	FRAT2	0.274			bioplex3_WMM WMM_only
AXIN1	FRAT2	0.25			bioplex3_WMM WMM_only
FRAT1	FRAT2	0.135		mutually_exclusive (P49840)	bioplex3_WMM WMM_only
GSKIP	FRAT2	0.078		mutually_exclusive (P49840)	bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
AXIN2	huMAP3_00673.1 huMAP3_10801.1 huMAP3_11257.1
GSKIP	huMAP3_00673.1 huMAP3_10801.1 huMAP3_11257.1 huMAP3_13368.1 huMAP3_14060.1
GSK3A	huMAP3_00673.1 huMAP3_04454.1 huMAP3_06005.1 huMAP3_07944.1 huMAP3_10801.1 huMAP3_10807.1 huMAP3_11257.1
FRAT2	huMAP3_01861.1 huMAP3_02919.1 huMAP3_09537.1 huMAP3_10801.1 huMAP3_11257.1
GSK3B	huMAP3_00673.1 huMAP3_10801.1 huMAP3_11257.1
FRAT1	huMAP3_00673.1 huMAP3_10801.1 huMAP3_11257.1
RILPL2	huMAP3_02919.1 huMAP3_09537.1 huMAP3_10801.1 huMAP3_11257.1
AXIN1	huMAP3_00673.1 huMAP3_01565.1 huMAP3_09115.1 huMAP3_10801.1 huMAP3_11257.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10801.1

Complex Portal: CPX-14345