hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10811.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SCO2 | Protein SCO2 homolog, mitochondrial | 5 | UniProt NCBI |
| FBXL12 | F-box/LRR-repeat protein 12 (F-box and leucine-rich repeat protein 12) (F-box protein FBL12) | 4 | UniProt NCBI |
| ZFYVE19 | Abscission/NoCut checkpoint regulator (ANCHR) (MLL partner containing FYVE domain) (Zinc finger FYVE domain-containing protein 19) | 5 | UniProt NCBI |
| VPS4B | Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1) | 5 | UniProt NCBI |
| VPS4A | Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6) (Protein SKD2) (VPS4-1) (hVPS4) | 5 | UniProt NCBI |
| TUFM | Elongation factor Tu, mitochondrial (EF-Tu) (P43) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0061764 | 0.00702301080125 | 0.333333333333 | VPS4A VPS4B | late endosome to lysosome transport via multivesicular body sorting pathway |
| REAC:R-HSA-162588 | 0.00902151290218 | 0.333333333333 | VPS4A VPS4B | Budding and maturation of HIV virion |
| REAC:R-HSA-917729 | 0.0111743831709 | 0.333333333333 | VPS4A VPS4B | Endosomal Sorting Complex Required For Transport (ESCRT) |
| KEGG:03250 | 0.0114872599973 | 0.333333333333 | VPS4A VPS4B | Viral life cycle - HIV-1 |
| HP:0002240 | 0.0212441588114 | 0.666666666667 | VPS4A TUFM SCO2 ZFYVE19 | Hepatomegaly |
| HP:0003271 | 0.0354575661861 | 0.666666666667 | VPS4A TUFM SCO2 ZFYVE19 | Visceromegaly |
| GO:0044878 | 0.042122686785 | 0.333333333333 | VPS4A ZFYVE19 | mitotic cytokinesis checkpoint signaling |
| HP:0001438 | 0.0497272491045 | 0.666666666667 | VPS4A TUFM SCO2 ZFYVE19 | Abnormal abdomen morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| VPS4A | VPS4B | 1.0 | 0.606 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| FBXL12 | VPS4A | 0.992 | 0.068 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| SCO2 | VPS4A | 0.985 | 0.018 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM |
| ZFYVE19 | VPS4A | 0.982 | 0.174 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TUFM | VPS4B | 0.958 | 0.074 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction |
| FBXL12 | VPS4B | 0.9 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only |
| FBXL12 | TUFM | 0.587 | 0.04 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| SCO2 | VPS4B | 0.513 | 0.018 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ZFYVE19 | VPS4B | 0.456 | 0.168 | bioplex_WMM bioplex3_WMM WMM_only |
| FBXL12 | SCO2 | 0.17 | 0.058 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| TUFM | VPS4A | 0.15 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM treiber_WMM |
| SCO2 | TUFM | 0.027 | 0.148 | bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| SCO2 | ZFYVE19 | 0.011 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes