hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10815.1
Complex Portal: CPX-24790
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PSPC1 | Paraspeckle component 1 (Paraspeckle protein 1) | 5 | UniProt NCBI |
| ORC6 | Origin recognition complex subunit 6 | 5 | UniProt NCBI |
| NONO | Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit) | 5 | UniProt NCBI |
| ESCO2 | N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment factor-like protein 2) (EFO2) (EFO2p) (hEFO2) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2) | 5 | UniProt NCBI |
| SFPQ | Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7285 | 7.68662167609e-05 | 0.5 | PSPC1 NONO | HEXIM1-DNA-PK-paraspeckle components-ribonucleoprotein complex |
| HP:0006443 | 0.00454201288615 | 0.5 | ORC6 ESCO2 | Patellar aplasia |
| HP:0006498 | 0.0108451581837 | 0.5 | ORC6 ESCO2 | Aplasia/Hypoplasia of the patella |
| HP:0012880 | 0.0135443934278 | 0.5 | ORC6 ESCO2 | Abnormal labia minora morphology |
| CORUM:330 | 0.0249718442456 | 0.25 | NONO | PSF-p54(nrb) complex |
| CORUM:1760 | 0.0249718442456 | 0.25 | NONO | TOP1-PSF-P54 complex |
| HPA:0570783 | 0.0258977031751 | 0.75 | PSPC1 ORC6 NONO | testis; preleptotene spermatocytes[High] |
| KEGG:04110 | 0.0280208578488 | 0.5 | ORC6 ESCO2 | Cell cycle |
| HP:0004278 | 0.028689358225 | 0.5 | NONO ESCO2 | Synostosis involving bones of the hand |
| WP:WP3594 | 0.03162086928 | 0.5 | PSPC1 NONO | Circadian rhythm genes |
| HP:0004209 | 0.0329509878386 | 0.75 | ESCO2 ORC6 NONO | Clinodactyly of the 5th finger |
| HP:0009179 | 0.0332300831153 | 0.75 | ESCO2 ORC6 NONO | Deviation of the 5th finger |
| HP:0040019 | 0.0410470782574 | 0.75 | ESCO2 ORC6 NONO | Finger clinodactyly |
| CORUM:335 | 0.049938562206 | 0.25 | NONO | p54(nrb)-PSF-matrin3 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NONO | SFPQ | 1.0 | 0.992 |
mutually_exclusive (Q8WXF1)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| PSPC1 | NONO | 1.0 | 0.62 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| PSPC1 | SFPQ | 0.999 | 0.674 |
mutually_exclusive (Q15233)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| ORC6 | NONO | 0.972 | 0.22 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PSPC1 | ESCO2 | 0.96 | 0.108 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| ORC6 | SFPQ | 0.959 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ORC6 | PSPC1 | 0.957 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NONO | ESCO2 | 0.856 | 0.102 | hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SFPQ | ESCO2 | 0.843 | 0.074 | hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ORC6 | ESCO2 | 0.102 | 0.164 | bioplex3_WMM WMM_only |
Related Complexes