hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10819.1
Complex Portal: CPX-22466
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ARRB1 | Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2) | 5 | UniProt NCBI |
| ARRB2 | Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3) | 5 | UniProt NCBI |
| ARR3 | Arrestin-C (Cone arrestin) (C-arrestin) (cArr) (Retinal cone arrestin-3) (X-arrestin) | 5 | UniProt NCBI |
| UTP25 | U3 small nucleolar RNA-associated protein 25 homolog (Digestive organ expansion factor homolog) (UTP25 small subunit processor component) | 5 | UniProt NCBI |
| SAG | S-arrestin (48 kDa protein) (Retinal S-antigen) (S-AG) (Rod photoreceptor arrestin) | 5 | UniProt NCBI |
| BRPF1 | Peregrin (Bromodomain and PHD finger-containing protein 1) (Protein Br140) | 5 | UniProt NCBI |
| TCOF1 | Treacle protein (Treacher Collins syndrome protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0002031 | 0.000161332517231 | 0.5 | ARRB1 ARRB2 ARR3 | G protein-coupled receptor internalization |
| GO:0002029 | 0.00042234232358 | 0.5 | ARRB1 ARRB2 ARR3 | desensitization of G protein-coupled receptor signaling pathway |
| GO:0022401 | 0.000548960443183 | 0.5 | ARRB1 ARRB2 ARR3 | negative adaptation of signaling pathway |
| GO:0023058 | 0.000548960443183 | 0.5 | ARRB1 ARRB2 ARR3 | adaptation of signaling pathway |
| REAC:R-HSA-5635838 | 0.00200991204249 | 0.333333333333 | ARRB1 ARRB2 | Activation of SMO |
| WP:WP4941 | 0.00210864528598 | 0.333333333333 | ARRB1 ARRB2 | GPR143 in melanocytes and retinal pigment epithelium cells |
| WP:WP4871 | 0.00497042421358 | 0.333333333333 | ARRB1 ARRB2 | Kisspeptin kisspeptin receptor system in the ovary |
| WP:WP4249 | 0.00666790414994 | 0.333333333333 | ARRB1 ARRB2 | Hedgehog signaling pathway |
| REAC:R-HSA-2122948 | 0.0070977267476 | 0.333333333333 | ARRB1 ARRB2 | Activated NOTCH1 Transmits Signal to the Nucleus |
| KEGG:04340 | 0.0071411999113 | 0.333333333333 | ARRB1 ARRB2 | Hedgehog signaling pathway |
| KEGG:04929 | 0.0071411999113 | 0.333333333333 | ARRB1 ARRB2 | GnRH secretion |
| REAC:R-HSA-456926 | 0.00902151290218 | 0.333333333333 | ARRB1 ARRB2 | Thrombin signalling through proteinase activated receptors (PARs) |
| REAC:R-HSA-6802948 | 0.0111743831709 | 0.333333333333 | ARRB1 ARRB2 | Signaling by high-kinase activity BRAF mutants |
| REAC:R-HSA-5674135 | 0.0144005758041 | 0.333333333333 | ARRB1 ARRB2 | MAP2K and MAPK activation |
| REAC:R-HSA-9656223 | 0.0152705482636 | 0.333333333333 | ARRB1 ARRB2 | Signaling by RAF1 mutants |
| KEGG:05032 | 0.0163630378499 | 0.333333333333 | ARRB1 ARRB2 | Morphine addiction |
| REAC:R-HSA-6802946 | 0.0180324600743 | 0.333333333333 | ARRB1 ARRB2 | Signaling by moderate kinase activity BRAF mutants |
| REAC:R-HSA-9649948 | 0.0180324600743 | 0.333333333333 | ARRB1 ARRB2 | Signaling downstream of RAS mutants |
| REAC:R-HSA-6802955 | 0.0180324600743 | 0.333333333333 | ARRB1 ARRB2 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-6802949 | 0.0180324600743 | 0.333333333333 | ARRB1 ARRB2 | Signaling by RAS mutants |
| GO:0045744 | 0.0188853212627 | 0.5 | ARRB1 ARRB2 ARR3 | negative regulation of G protein-coupled receptor signaling pathway |
| WP:WP5094 | 0.0220152039288 | 0.333333333333 | ARRB1 ARRB2 | Orexin receptor pathway |
| KEGG:04740 | 0.0237939838034 | 0.333333333333 | ARRB1 ARRB2 | Olfactory transduction |
| KEGG:04928 | 0.0243770301627 | 0.333333333333 | ARRB1 ARRB2 | Parathyroid hormone synthesis, secretion and action |
| WP:WP2355 | 0.0275906315528 | 0.333333333333 | ARRB1 ARRB2 | Corticotropin releasing hormone signaling pathway |
| REAC:R-HSA-6802952 | 0.0393724000146 | 0.333333333333 | ARRB1 ARRB2 | Signaling by BRAF and RAF1 fusions |
| KEGG:04926 | 0.0412011786405 | 0.333333333333 | ARRB1 ARRB2 | Relaxin signaling pathway |
| KEGG:04728 | 0.0419636118509 | 0.333333333333 | ARRB1 ARRB2 | Dopaminergic synapse |
| GO:0031701 | 0.042122686785 | 0.333333333333 | ARRB1 ARRB2 | angiotensin receptor binding |
| REAC:R-HSA-1980143 | 0.0437202891307 | 0.333333333333 | ARRB1 ARRB2 | Signaling by NOTCH1 |
| CORUM:1297 | 0.0499436884912 | 0.166666666667 | ARRB2 | MKK4-ARRB2-ASK1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ARRB1 | SAG | 0.999 | 0.22 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TCOF1 | ARRB2 | 0.99 | 0.0827111111111 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| ARRB2 | ARRB1 | 0.986 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TCOF1 | ARRB1 | 0.985 | 0.042 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ARRB2 | BRPF1 | 0.975 | 0.113666666667 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ARRB2 | UTP25 | 0.974 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ARRB2 | ARR3 | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| BRPF1 | ARRB1 | 0.968 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ARR3 | ARRB1 | 0.53 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ARR3 | BRPF1 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TCOF1 | UTP25 | 0.424 | 0.2 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| BRPF1 | UTP25 | 0.398 | 0.048 | bioplex_WMM bioplex3_WMM WMM_only | |
| BRPF1 | SAG | 0.303 | 0.08 | bioplex_WMM bioplex3_WMM WMM_only | |
| TCOF1 | BRPF1 | 0.291 | 0.084 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| TCOF1 | SAG | 0.283 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only | |
| TCOF1 | ARR3 | 0.225 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ARRB2 | SAG | 0.213 | 0.14 | bioplex_WMM bioplex3_WMM WMM_only | |
| UTP25 | ARRB1 | 0.179 | 0.04 | bioplex_WMM bioplex3_WMM WMM_only | |
| ARR3 | UTP25 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes