hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10830.1
Complex Portal: CPX-13652
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IGF2 | Insulin-like growth factor II (IGF-II) (Somatomedin-A) (T3M-11-derived growth factor) [Cleaved into: Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; Preptin] | 5 | UniProt NCBI |
| IGFBP2 | Insulin-like growth factor-binding protein 2 (IBP-2) (IGF-binding protein 2) (IGFBP-2) | 5 | UniProt NCBI |
| NMB | Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B] | 5 | UniProt NCBI |
| RNF123 | E3 ubiquitin-protein ligase RNF123 (EC 2.3.2.27) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) | 5 | UniProt NCBI |
| INSL3 | Insulin-like 3 (Leydig insulin-like peptide) (Ley-I-L) (Relaxin-like factor) [Cleaved into: Insulin-like 3 B chain; Insulin-like 3 A chain] | 5 | UniProt NCBI |
| PNPLA1 | Omega-hydroxyceramide transacylase (EC 2.3.1.296) (Patatin-like phospholipase domain-containing protein 1) | 5 | UniProt NCBI |
| UBAC1 | Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (Glialblastoma cell differentiation-related protein 1) (Kip1 ubiquitination-promoting complex protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:386 | 1.70876175213e-05 | 0.333333333333 | RNF123 UBAC1 | Ubiquitin E3 ligase (UBADC1, RNF123) |
| HP:0012741 | 0.00841070885474 | 0.333333333333 | IGF2 INSL3 | Unilateral cryptorchidism |
| CORUM:6191 | 0.0499436884912 | 0.166666666667 | IGF2 | IGF2-IGFBP2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RNF123 | UBAC1 | 0.999 | 0.144 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| IGF2 | IGFBP2 | 0.998 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NMB | UBAC1 | 0.997 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NMB | RNF123 | 0.994 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| UBAC1 | PNPLA1 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| RNF123 | PNPLA1 | 0.981 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| INSL3 | RNF123 | 0.978 |
mutually_exclusive (Q9BSL1)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| IGF2 | UBAC1 | 0.974 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| IGF2 | RNF123 | 0.972 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| INSL3 | UBAC1 | 0.96 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| IGFBP2 | UBAC1 | 0.341 | 0.084 | bioplex3_WMM WMM_only | |
| IGFBP2 | RNF123 | 0.305 | 0.186 | bioplex3_WMM WMM_only |
Related Complexes