hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10835.1
Complex Portal: CPX-19294
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ABHD11 | sn-1-specific diacylglycerol lipase ABHD11 (EC 3.1.1.116) (Alpha/beta hydrolase domain-containing protein 11) (Abhydrolase domain-containing protein 11) (Williams-Beuren syndrome chromosomal region 21 protein) | 5 | UniProt NCBI |
| TSFM | Elongation factor Ts, mitochondrial (EF-Ts) (EF-TsMt) | 5 | UniProt NCBI |
| FAHD1 | Acylpyruvase FAHD1, mitochondrial (EC 3.7.1.5) (Fumarylacetoacetate hydrolase domain-containing protein 1) (FAH domain-containing protein 1) (Oxaloacetate decarboxylase) (OAA decarboxylase) (EC 4.1.1.112) (YisK-like protein) | 5 | UniProt NCBI |
| CPT2 | Carnitine O-palmitoyltransferase 2, mitochondrial (EC 2.3.1.21) (Carnitine palmitoyltransferase II) (CPT II) | 5 | UniProt NCBI |
| PCK2 | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32) (Phosphoenolpyruvate carboxykinase 2, mitochondrial) (mtPCK2) | 5 | UniProt NCBI |
| GUK1 | Guanylate kinase (EC 2.7.4.8) (GMP kinase) (Guanylate kinase 1) | 5 | UniProt NCBI |
| TRMT5 | tRNA (guanine(37)-N1)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) (tRNA methyltransferase 5 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005759 | 0.0156049166687 | 0.714285714286 | FAHD1 ABHD11 TRMT5 PCK2 TSFM | mitochondrial matrix |
| KEGG:03320 | 0.0173334447573 | 0.285714285714 | CPT2 PCK2 | PPAR signaling pathway |
| HPA:0271143 | 0.0186354583897 | 0.428571428571 | PCK2 FAHD1 CPT2 | kidney; proximal tubules (cell body)[High] |
| WP:WP3942 | 0.0242608328425 | 0.285714285714 | CPT2 PCK2 | PPAR signaling pathway |
| HP:0003287 | 0.04831924436 | 0.428571428571 | TRMT5 TSFM CPT2 | Abnormality of mitochondrial metabolism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FAHD1 | CPT2 | 0.987 | 0.206 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FAHD1 | GUK1 | 0.977 | 0.042 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FAHD1 | TRMT5 | 0.975 | 0.034 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FAHD1 | TSFM | 0.968 | 0.062 | bioplex3_WMM bioplex3_HCT116 fraction | |
| TSFM | CPT2 | 0.961 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only | |
| PCK2 | FAHD1 | 0.96 | 0.04 | bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| FAHD1 | ABHD11 | 0.957 | 0.064 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 fraction |
| GUK1 | TRMT5 | 0.715 | 0.014 | bioplex3_WMM WMM_only | |
| GUK1 | ABHD11 | 0.621 | 0.062 | bioplex3_WMM WMM_only | |
| GUK1 | TSFM | 0.614 | 0.042 | bioplex3_WMM WMM_only | |
| ABHD11 | TSFM | 0.544 | 0.068 | bioplex_WMM bioplex3_WMM WMM_only | |
| PCK2 | CPT2 | 0.415 | 0.29 | bioplex_WMM bioplex3_WMM WMM_only | |
| TRMT5 | TSFM | 0.369 | 0.026 | bioplex3_WMM youn_WMM WMM_only | |
| PCK2 | ABHD11 | 0.316 | 0.126 | bioplex_WMM bioplex3_WMM fraction | |
| TRMT5 | CPT2 | 0.203 | 0.026 | bioplex3_WMM youn_WMM WMM_only | |
| PCK2 | TRMT5 | 0.158 | 0.028 | bioplex3_WMM youn_WMM WMM_only | |
| TRMT5 | ABHD11 | 0.131 | 0.008 | bioplex3_WMM WMM_only | |
| PCK2 | GUK1 | 0.108 | 0.052 | bioplex_WMM bioplex3_WMM WMM_only | |
| GUK1 | CPT2 | 0.101 | 0.072 | bioplex3_WMM WMM_only | |
| ABHD11 | CPT2 | 0.083 | 0.188 | bioplex3_WMM WMM_only | |
| PCK2 | TSFM | 0.024 | 0.15 | bioplex_WMM bioplex3_WMM youn_WMM fraction |
Related Complexes