hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10838.1
Complex Portal: CPX-11230
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| WBP2 | WW domain-binding protein 2 (WBP-2) | 5 | UniProt NCBI |
| EVL | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | 5 | UniProt NCBI |
| VASP | Vasodilator-stimulated phosphoprotein (VASP) | 5 | UniProt NCBI |
| PFN2 | Profilin-2 (Profilin II) | 5 | UniProt NCBI |
| ZYX | Zyxin (Zyxin-2) | 5 | UniProt NCBI |
| SESN1 | Sestrin-1 (EC 1.11.1.-) (p53-regulated protein PA26) | 5 | UniProt NCBI |
| ENAH | Protein enabled homolog | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-202433 | 2.62784267685e-05 | 0.428571428571 | ENAH EVL VASP | Generation of second messenger molecules |
| KEGG:04015 | 2.85545005268e-05 | 0.571428571429 | PFN2 ENAH EVL VASP | Rap1 signaling pathway |
| REAC:R-HSA-376176 | 0.000271661382471 | 0.571428571429 | PFN2 ENAH EVL VASP | Signaling by ROBO receptors |
| GO:0005522 | 0.00040312426486 | 0.428571428571 | ENAH EVL VASP | profilin binding |
| REAC:R-HSA-202403 | 0.00246283493288 | 0.428571428571 | ENAH EVL VASP | TCR signaling |
| GO:0007015 | 0.00639875049874 | 0.714285714286 | PFN2 ZYX ENAH EVL VASP | actin filament organization |
| REAC:R-HSA-422475 | 0.00732241318188 | 0.571428571429 | PFN2 ENAH EVL VASP | Axon guidance |
| GO:0008154 | 0.00742193936463 | 0.571428571429 | PFN2 ENAH EVL VASP | actin polymerization or depolymerization |
| REAC:R-HSA-9675108 | 0.00845717716544 | 0.571428571429 | PFN2 ENAH EVL VASP | Nervous system development |
| GO:0030838 | 0.0150353457168 | 0.428571428571 | PFN2 EVL VASP | positive regulation of actin filament polymerization |
| CORUM:6731 | 0.0499958217778 | 0.142857142857 | VASP | VASP-CXCR2 complex, CXCL8 stimulated |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EVL | ENAH | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 gupta_WMM fraction | ||
| VASP | ENAH | 1.0 | 0.052 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| EVL | VASP | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction | ||
| EVL | PFN2 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ENAH | ZYX | 0.996 | 0.072 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM | |
| PFN2 | SESN1 | 0.994 | 0.086 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| VASP | PFN2 | 0.982 | 0.16 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| VASP | ZYX | 0.97 | 0.424 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction | |
| WBP2 | VASP | 0.957 | 0.034 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ENAH | PFN2 | 0.952 | 0.156 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | |
| WBP2 | PFN2 | 0.563 | 0.118 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EVL | WBP2 | 0.419 | bioplex_WMM bioplex3_WMM WMM_only | ||
| WBP2 | ENAH | 0.204 | 0.036 | bioplex_WMM bioplex3_WMM WMM_only | |
| WBP2 | ZYX | 0.112 | 0.054 | bioplex_WMM bioplex3_WMM WMM_only | |
| EVL | ZYX | 0.057 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | ||
| ENAH | SESN1 | 0.051 | 0.07 | bioplex3_WMM WMM_only | |
| ZYX | PFN2 | 0.016 | 0.134 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | |
| VASP | SESN1 | 0.013 | 0.058 | bioplex3_WMM WMM_only | |
| WBP2 | SESN1 | 0.011 | 0.06 | bioplex3_WMM WMM_only |
Related Complexes