hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10842.1
Complex Portal: CPX-10764
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BOLA2 | BolA-like protein 2 | 5 | UniProt NCBI |
| GLRX3 | Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2) | 5 | UniProt NCBI |
| NDOR1 | NADPH-dependent diflavin oxidoreductase 1 (EC 1.18.1.-) (NADPH-dependent FMN and FAD-containing oxidoreductase) (Novel reductase 1) | 5 | UniProt NCBI |
| GLRX5 | Glutaredoxin-related protein 5, mitochondrial (Monothiol glutaredoxin-5) | 5 | UniProt NCBI |
| NUBP1 | Cytosolic Fe-S cluster assembly factor NUBP1 (Nucleotide-binding protein 1) (NBP 1) | 5 | UniProt NCBI |
| CIAPIN1 | Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog) | 5 | UniProt NCBI |
| BOLA1 | BolA-like protein 1 (hBolA) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0016226 | 1.39314752259e-12 | 1.0 | BOLA1 CIAPIN1 NUBP1 GLRX3 NDOR1 GLRX5 | iron-sulfur cluster assembly |
| GO:0031163 | 1.39314752259e-12 | 1.0 | BOLA1 CIAPIN1 NUBP1 GLRX3 NDOR1 GLRX5 | metallo-sulfur cluster assembly |
| REAC:R-HSA-2564830 | 2.01823692347e-06 | 0.5 | NDOR1 CIAPIN1 NUBP1 | Cytosolic iron-sulfur cluster assembly |
| GO:0006879 | 9.81259188038e-05 | 0.666666666667 | GLRX3 GLRX5 BOLA1 NUBP1 | intracellular iron ion homeostasis |
| GO:1990229 | 0.000316805542726 | 0.5 | GLRX3 GLRX5 BOLA1 | iron-sulfur cluster assembly complex |
| WP:WP5152 | 0.000914914863609 | 0.333333333333 | NUBP1 GLRX5 | Iron sulfur cluster biogenesis |
| GO:0045454 | 0.0114488243093 | 0.5 | GLRX3 GLRX5 BOLA1 | cell redox homeostasis |
| CORUM:6958 | 0.0499436884912 | 0.166666666667 | GLRX3 | BOLA2-GLRX3 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GLRX3 | CIAPIN1 | 1.0 | 0.3 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| BOLA1 | GLRX3 | 1.0 | 0.114 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NDOR1 | CIAPIN1 | 0.998 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BOLA1 | GLRX5 | 0.996 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| BOLA1 | CIAPIN1 | 0.996 | 0.116 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BOLA2 | CIAPIN1 | 0.993 | 0.098 |
structurally_consistent (O76003)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GLRX3 | BOLA2 | 0.987 | 0.22 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GLRX3 | NDOR1 | 0.983 | 0.08 | bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM fraction | |
| NUBP1 | CIAPIN1 | 0.972 | 0.338 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction | |
| BOLA1 | NDOR1 | 0.878 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only | |
| BOLA1 | BOLA2 | 0.868 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only | |
| NDOR1 | BOLA2 | 0.744 | 0.116 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| NUBP1 | GLRX3 | 0.658 | 0.108 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| BOLA1 | NUBP1 | 0.591 | 0.162 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GLRX5 | BOLA2 | 0.531 | 0.052 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| NUBP1 | NDOR1 | 0.492 | 0.092 | bioplex_WMM bioplex3_WMM WMM_only | |
| GLRX5 | GLRX3 | 0.329 | 0.11 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| GLRX5 | CIAPIN1 | 0.052 | 0.052 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| GLRX5 | NUBP1 | 0.039 | 0.026 | bioplex_WMM bioplex3_WMM WMM_only | |
| NUBP1 | BOLA2 | 0.03 | 0.068 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes