hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10846.1
Complex Portal: CPX-18379
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CSTB | Cystatin-B (CPI-B) (Liver thiol proteinase inhibitor) (Stefin-B) | 5 | UniProt NCBI |
| CTSH | Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H (EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain] | 5 | UniProt NCBI |
| VWA3B | von Willebrand factor A domain-containing protein 3B (VWA domain-containing protein 3B) | 5 | UniProt NCBI |
| CTSB | Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] | 5 | UniProt NCBI |
| CST3 | Cystatin-C (Cystatin-3) (Gamma-trace) (Neuroendocrine basic polypeptide) (Post-gamma-globulin) | 5 | UniProt NCBI |
| AIRE | Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein) | 5 | UniProt NCBI |
| CTSL | Procathepsin L (EC 3.4.22.15) (Cathepsin L1) (Major excreted protein) (MEP) [Cleaved into: Cathepsin L; Cathepsin L heavy chain; Cathepsin L light chain] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0097067 | 0.000117650375223 | 0.428571428571 | CTSH CTSL CTSB | cellular response to thyroid hormone stimulus |
| GO:0097066 | 0.0001882019462 | 0.428571428571 | CTSH CTSL CTSB | response to thyroid hormone |
| HPA:0271143 | 0.000327391776551 | 0.571428571429 | CTSH CST3 CTSL CTSB | kidney; proximal tubules (cell body)[High] |
| KEGG:04210 | 0.000962758015712 | 0.428571428571 | CTSH CTSL CTSB | Apoptosis |
| KEGG:04142 | 0.00103678431353 | 0.428571428571 | CTSH CTSL CTSB | Lysosome |
| HPA:0461451 | 0.00105401230366 | 0.571428571429 | CTSH CSTB CST3 CTSB | skin 1; hair follicles[>=Low] |
| REAC:R-HSA-1679131 | 0.00209171533568 | 0.285714285714 | CTSB CTSL | Trafficking and processing of endosomal TLR |
| REAC:R-HSA-168249 | 0.00300736036824 | 0.714285714286 | CTSL CTSH CSTB CST3 CTSB | Innate Immune System |
| REAC:R-HSA-2132295 | 0.00331331870922 | 0.428571428571 | CTSH CTSL CTSB | MHC class II antigen presentation |
| HPA:0271142 | 0.00448406864975 | 0.571428571429 | CTSH CST3 CTSL CTSB | kidney; proximal tubules (cell body)[>=Medium] |
| REAC:R-HSA-6798695 | 0.00462905575557 | 0.571428571429 | CTSH CSTB CST3 CTSB | Neutrophil degranulation |
| GO:1904813 | 0.00670167137681 | 0.571428571429 | CTSH CSTB CST3 CTSB | ficolin-1-rich granule lumen |
| GO:0031904 | 0.00870569405676 | 0.428571428571 | CTSH CTSL CTSB | endosome lumen |
| GO:0030574 | 0.00979189312029 | 0.428571428571 | CTSB CST3 CTSL | collagen catabolic process |
| HPA:0271141 | 0.0115413333869 | 0.571428571429 | CTSH CST3 CTSL CTSB | kidney; proximal tubules (cell body)[>=Low] |
| GO:0061134 | 0.0142054380156 | 0.571428571429 | CTSH CSTB CTSL CST3 | peptidase regulator activity |
| KEGG:04612 | 0.01853051749 | 0.285714285714 | CTSB CTSL | Antigen processing and presentation |
| GO:0101002 | 0.0260575019522 | 0.571428571429 | CTSH CSTB CST3 CTSB | ficolin-1-rich granule |
| GO:0060309 | 0.0294899169624 | 0.285714285714 | CTSL CST3 | elastin catabolic process |
| REAC:R-HSA-2022090 | 0.0407752524289 | 0.285714285714 | CTSB CTSL | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-1442490 | 0.0443383907933 | 0.285714285714 | CTSB CTSL | Collagen degradation |
| CORUM:1985 | 0.0499958217778 | 0.142857142857 | AIRE | AIRE homodimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CTSL | CST3 | 0.998 | 0.104 |
mutually_exclusive (P04080)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 fraction |
| CTSB | CST3 | 0.994 | 0.330580645161 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| CST3 | CTSH | 0.989 | 0.224 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| AIRE | CTSH | 0.975 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CTSL | CTSH | 0.969 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CTSH | VWA3B | 0.966 | 0.05 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CSTB | CTSH | 0.951 | 0.134 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CST3 | CSTB | 0.903 | 0.192 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| CTSL | CTSB | 0.726 | 0.172424242424 |
mutually_exclusive (P04080)
structurally_consistent (dimer) |
Guru bioplex3_WMM fraction |
| AIRE | CTSB | 0.657 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CTSL | CSTB | 0.355 | 0.086 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex3_WMM |
| CTSB | CTSH | 0.14 | 0.21425 |
structurally_consistent (P01034)
|
bioplex_WMM bioplex3_WMM WMM_only |
| CTSB | CSTB | 0.068 | 0.088 |
mutually_exclusive (P07711)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM WMM_only |
| CSTB | VWA3B | 0.005 | 0.04 | bioplex3_HEK293 bioplex () bioplex3_HCT116 |
Related Complexes