hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10851.1
Complex Portal: CPX-18189
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SMG1 | Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1) | 5 | UniProt NCBI |
| DYNC2LI1 | Cytoplasmic dynein 2 light intermediate chain 1 (Dynein 2 light intermediate chain) | 5 | UniProt NCBI |
| EPHA1 | Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH) | 5 | UniProt NCBI |
| ESPNL | Espin-like protein | 4 | UniProt NCBI |
| WDR13 | WD repeat-containing protein 13 | 3 | UniProt NCBI |
| USP34 | Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.4.19.12) (Deubiquitinating enzyme 34) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) | 5 | UniProt NCBI |
| SMG8 | Nonsense-mediated mRNA decay factor SMG8 (Amplified in breast cancer gene 2 protein) (Protein smg-8 homolog) | 5 | UniProt NCBI |
| DYNC2H1 | Cytoplasmic dynein 2 heavy chain 1 (Cytoplasmic dynein 2 heavy chain) (Dynein cytoplasmic heavy chain 2) (Dynein heavy chain 11) (hDHC11) (Dynein heavy chain isotype 1B) | 5 | UniProt NCBI |
| RELCH | RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats) | 4 | UniProt NCBI |
| SMG9 | Nonsense-mediated mRNA decay factor SMG9 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6236 | 0.00202261196918 | 0.2 | DYNC2H1 DYNC2LI1 | Dynein-2 complex, cytoplasmic |
| REAC:R-HSA-975957 | 0.0128742572889 | 0.3 | SMG8 SMG1 SMG9 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-927802 | 0.0128742572889 | 0.3 | SMG8 SMG1 SMG9 | Nonsense-Mediated Decay (NMD) |
| WP:WP4532 | 0.0144252840529 | 0.2 | DYNC2H1 DYNC2LI1 | Intraflagellar transport proteins binding to dynein |
| KEGG:04962 | 0.0163216862479 | 0.2 | DYNC2H1 DYNC2LI1 | Vasopressin-regulated water reabsorption |
| WP:WP5085 | 0.0319043985122 | 0.2 | DYNC2H1 DYNC2LI1 | Vasopressin regulated water reabsorption |
| HP:0000888 | 0.0431720528278 | 0.2 | DYNC2H1 DYNC2LI1 | Horizontal ribs |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DYNC2LI1 | DYNC2H1 | 0.998 | 0.1 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM | |
| SMG1 | SMG9 | 0.995 | 0.092 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| RELCH | EPHA1 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| RELCH | WDR13 | 0.982 | 0.154 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| SMG9 | EPHA1 | 0.982 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| EPHA1 | ESPNL | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| WDR13 | EPHA1 | 0.976 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SMG1 | EPHA1 | 0.974 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SMG8 | EPHA1 | 0.972 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SMG8 | SMG9 | 0.969 | 0.188 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| SMG8 | SMG1 | 0.966 | 0.14 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| USP34 | EPHA1 | 0.964 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| DYNC2LI1 | EPHA1 | 0.956 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| EPHA1 | DYNC2H1 | 0.956 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| USP34 | SMG8 | 0.668 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only | |
| WDR13 | ESPNL | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SMG9 | ESPNL | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SMG1 | ESPNL | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RELCH | ESPNL | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ESPNL | DYNC2H1 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SMG8 | DYNC2LI1 | 0.474 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only | |
| SMG1 | DYNC2H1 | 0.366 | 0.134 | bioplex_WMM bioplex3_WMM WMM_only | |
| SMG9 | WDR13 | 0.303 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only | |
| SMG1 | WDR13 | 0.303 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only | |
| USP34 | DYNC2H1 | 0.292 | 0.068 | bioplex_WMM bioplex3_WMM WMM_only | |
| SMG1 | DYNC2LI1 | 0.211 | 0.188 | bioplex_WMM bioplex3_WMM WMM_only | |
| USP34 | SMG9 | 0.194 | 0.054 | bioplex_WMM bioplex3_WMM WMM_only | |
| SMG9 | DYNC2H1 | 0.191 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only | |
| USP34 | RELCH | 0.183 | 0.032 | bioplex_WMM bioplex3_WMM WMM_only | |
| SMG9 | RELCH | 0.181 | 0.034 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| DYNC2LI1 | ESPNL | 0.18 | bioplex_WMM bioplex3_WMM WMM_only | ||
| USP34 | WDR13 | 0.179 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only | |
| USP34 | SMG1 | 0.179 | 0.24 | bioplex_WMM bioplex3_WMM WMM_only | |
| WDR13 | DYNC2H1 | 0.164 | 0.118 | bioplex_WMM bioplex3_WMM WMM_only | |
| RELCH | DYNC2H1 | 0.164 | 0.054 | bioplex_WMM bioplex3_WMM WMM_only | |
| SMG9 | DYNC2LI1 | 0.159 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only | |
| RELCH | DYNC2LI1 | 0.147 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only | |
| USP34 | ESPNL | 0.143 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SMG8 | ESPNL | 0.143 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SMG8 | DYNC2H1 | 0.119 | 0.024 | bioplex_WMM bioplex3_WMM WMM_only | |
| SMG8 | RELCH | 0.114 | 0.02 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| WDR13 | DYNC2LI1 | 0.104 | 0.118 | bioplex_WMM bioplex3_WMM WMM_only | |
| SMG8 | WDR13 | 0.1 | 0.04 | bioplex_WMM bioplex3_WMM WMM_only | |
| SMG1 | RELCH | 0.078 | 0.066 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| USP34 | DYNC2LI1 | 0.058 | 0.15 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes