hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10852.1
Complex Portal: CPX-21416
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MMEL1 | Membrane metallo-endopeptidase-like 1 (EC 3.4.24.11) (Membrane metallo-endopeptidase-like 2) (NEP2(m)) (Neprilysin II) (NEPII) (Neprilysin-2) (NEP2) (NL2) [Cleaved into: Membrane metallo-endopeptidase-like 1, soluble form (Neprilysin-2 secreted) (NEP2(s))] | 5 | UniProt NCBI |
| MMP3 | Stromelysin-1 (SL-1) (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) | 5 | UniProt NCBI |
| TIGD7 | Tigger transposable element-derived protein 7 | 3 | UniProt NCBI |
| APOE | Apolipoprotein E (Apo-E) | 5 | UniProt NCBI |
| MMRN1 | Multimerin-1 (EMILIN-4) (Elastin microfibril interface located protein 4) (Elastin microfibril interfacer 4) (Endothelial cell multimerin) [Cleaved into: Platelet glycoprotein Ia*; 155 kDa platelet multimerin (p-155) (p155)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0001114 | 0.00768171284681 | 0.4 | MMEL1 APOE | Xanthelasma |
| HP:0010732 | 0.00870474912182 | 0.4 | MMEL1 APOE | Nodular changes affecting the eyelids |
| HP:0000991 | 0.0207761643339 | 0.4 | MMEL1 APOE | Xanthomatosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MMP3 | MMEL1 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MMP3 | TIGD7 | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| APOE | MMP3 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| APOE | MMRN1 | 0.978 | 0.134 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| APOE | MMEL1 | 0.055 | bioplex3_WMM WMM_only |
Related Complexes