hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10855.1

Complex Portal: CPX-11439

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
FAM241A	Uncharacterized protein FAM241A	2	UniProt NCBI
TMEM208	Transmembrane protein 208	5	UniProt NCBI
PRAF2	PRA1 family protein 2	5	UniProt NCBI
SCAMP4	Secretory carrier-associated membrane protein 4 (Secretory carrier membrane protein 4)	5	UniProt NCBI
TMEM170A	Transmembrane protein 170A	5	UniProt NCBI
REEP6	Receptor expression-enhancing protein 6 (Polyposis locus protein 1-like 1)	5	UniProt NCBI
RABAC1	Prenylated Rab acceptor protein 1 (PRA1 family protein 1)	5	UniProt NCBI
TMEM68	DGAT1/2-independent enzyme synthesizing storage lipids (DIESL) (EC 2.3.1.-) (2-acylglycerol/1,2-diacylglycerol O-acyltransferase) (Monoacylglycerol/Diacylglycerol O-acyltransferase) (MGAT/DGAT) (EC 2.3.1.20, EC 2.3.1.22) (Transmembrane protein 68)	5	UniProt NCBI
ARL6IP1	ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL-6-interacting protein 1) (Aip-1) (Apoptotic regulator in the membrane of the endoplasmic reticulum)	5	UniProt NCBI
REEP5	Receptor expression-enhancing protein 5 (Polyposis locus protein 1) (Protein TB2)	5	UniProt NCBI
RTN3	Reticulon-3 (Homolog of ASY protein) (HAP) (Neuroendocrine-specific protein-like 2) (NSP-like protein 2) (Neuroendocrine-specific protein-like II) (NSP-like protein II) (NSPLII)	5	UniProt NCBI
TMEM128	Transmembrane protein 128	5	UniProt NCBI
SVOPL	Putative transporter SVOPL (SV2-related protein-like) (SVOP-like protein)	3	UniProt NCBI
ARL6IP5	PRA1 family protein 3 (ADP-ribosylation factor-like protein 6-interacting protein 5) (ARL-6-interacting protein 5) (Aip-5) (Cytoskeleton-related vitamin A-responsive protein) (Dermal papilla-derived protein 11) (GTRAP3-18) (Glutamate transporter EAAC1-interacting protein) (JM5) (Prenylated Rab acceptor protein 2) (Protein JWa) (Putative MAPK-activating protein PM27)	5	UniProt NCBI
PRRT1	Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) (Synapse differentiation-induced protein 4) (SynDIG4)	5	UniProt NCBI
FAM241B	Protein FAM241B	5	UniProt NCBI
RTN4	Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5)	5	UniProt NCBI
HSD17B2	17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239)	5	UniProt NCBI
RTN1	Reticulon-1 (Neuroendocrine-specific protein)	5	UniProt NCBI
PILRB	Paired immunoglobulin-like type 2 receptor beta (Activating receptor PILR-beta) (Cell surface receptor FDFACT)	4	UniProt NCBI
FAM210B	Protein FAM210B, mitochondrial	5	UniProt NCBI
RTN2	Reticulon-2 (Neuroendocrine-specific protein-like 1) (NSP-like protein 1) (Neuroendocrine-specific protein-like I) (NSP-like protein I) (NSPLI)	5	UniProt NCBI
IFITM3	Interferon-induced transmembrane protein 3 (Dispanin subfamily A member 2b) (DSPA2b) (Interferon-inducible protein 1-8U)	5	UniProt NCBI
MOG	Myelin-oligodendrocyte glycoprotein	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0071787	1.396459195e-06	0.166666666667	RTN3 ARL6IP1 RTN1 RTN4	endoplasmic reticulum tubular network formation
GO:0007029	1.65174647346e-06	0.291666666667	RTN3 RTN4 ARL6IP1 TMEM170A REEP6 RTN1 REEP5	endoplasmic reticulum organization
GO:0071786	5.83798292663e-06	0.208333333333	RTN3 RTN4 TMEM170A RTN1 ARL6IP1	endoplasmic reticulum tubular network organization
GO:1902430	0.00019795084604	0.166666666667	RTN3 RTN4 RTN2 RTN1	negative regulation of amyloid-beta formation
GO:1902992	0.000377078861379	0.166666666667	RTN3 RTN4 RTN2 RTN1	negative regulation of amyloid precursor protein catabolic process
HPA:0090942	0.00152754580991	0.25	RTN3 MOG RTN1 PRAF2 PRRT1 RTN4	cerebellum; Purkinje cells - cytoplasm/membrane[>=Medium]
HPA:0090952	0.00166813569298	0.208333333333	PRAF2 MOG RTN4 RTN1 PRRT1	cerebellum; Purkinje cells - dendrites[>=Medium]
HPA:0090951	0.00257137746567	0.208333333333	PRAF2 MOG RTN4 RTN1 PRRT1	cerebellum; Purkinje cells - dendrites[>=Low]
HPA:0090941	0.0045091018704	0.25	RTN3 MOG RTN1 PRAF2 PRRT1 RTN4	cerebellum; Purkinje cells - cytoplasm/membrane[>=Low]
GO:1902003	0.00478481888133	0.166666666667	RTN3 RTN4 RTN2 RTN1	regulation of amyloid-beta formation
GO:1902991	0.00854106905186	0.166666666667	RTN3 RTN4 RTN2 RTN1	regulation of amyloid precursor protein catabolic process
GO:0034205	0.0110832759943	0.166666666667	RTN3 RTN4 RTN2 RTN1	amyloid-beta formation
GO:0050435	0.0198836963485	0.166666666667	RTN3 RTN4 RTN2 RTN1	amyloid-beta metabolic process
GO:0042987	0.0300189079892	0.166666666667	RTN3 RTN4 RTN2 RTN1	amyloid precursor protein catabolic process
GO:0090158	0.0423869429414	0.125	REEP5 ARL6IP1 RTN4	endoplasmic reticulum membrane organization
HPA:0481302	0.0479252071774	0.208333333333	RABAC1 HSD17B2 MOG REEP6 REEP5	small intestine; enterocytes[>=Medium]

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
REEP6	REEP5	1.0		mutually_exclusive (Q9NZC3) structurally_consistent (dimer)
REEP5	PRAF2	0.999	0.096	structurally_consistent (dimer)
RTN4	ARL6IP1	0.999	0.206
RTN3	RTN4	0.999	0.298	mutually_exclusive (O75298)
REEP5	FAM241B	0.999	0.082
FAM210B	REEP5	0.999	0.134
RTN4	RTN2	0.999	0.114	structurally_consistent (dimer)
REEP5	RABAC1	0.999	0.104
RABAC1	RTN4	0.999	0.064
FAM241A	RTN4	0.998	0.088
REEP6	FAM241A	0.998
REEP5	FAM241A	0.998	0.148
REEP5	SCAMP4	0.998	0.03
FAM241A	RTN2	0.998	0.054
TMEM68	REEP5	0.998	0.206
RTN1	RTN2	0.998	0.102
RTN1	RTN4	0.998	0.226
REEP5	TMEM208	0.997	0.14
REEP6	TMEM208	0.997
ARL6IP5	RTN4	0.997	0.154
ARL6IP5	FAM241A	0.996	0.048
RTN3	FAM241A	0.996	0.064
FAM241B	FAM241A	0.995	0.062
FAM241B	TMEM208	0.995	0.086
ARL6IP5	IFITM3	0.995	0.166846153846
FAM241B	RTN4	0.994	0.128
FAM210B	RTN4	0.994	0.13
RTN3	TMEM208	0.993	0.14
TMEM208	RTN4	0.991	0.105263157895
REEP6	RTN3	0.991
RTN4	IFITM3	0.991	0.254545454545
ARL6IP5	REEP5	0.99	0.236	mutually_exclusive (O60831)
ARL6IP5	RTN3	0.989	0.104
RTN4	PRAF2	0.989	0.124
ARL6IP1	IFITM3	0.989	0.09
RTN3	RTN2	0.988	0.1	structurally_consistent (dimer)
TMEM128	REEP6	0.987
PILRB	FAM241A	0.987
REEP6	IFITM3	0.987
RTN1	IFITM3	0.987	0.064
RTN3	FAM241B	0.986	0.1
RTN1	FAM241A	0.986	0.13
TMEM128	REEP5	0.986	0.052
REEP5	RTN4	0.984	0.194
RTN3	IFITM3	0.983	0.24
PRAF2	IFITM3	0.983	0.052
RTN3	ARL6IP1	0.981	0.088
ARL6IP5	FAM241B	0.98	0.118
REEP6	SCAMP4	0.979
TMEM128	TMEM208	0.977	0.122
REEP5	IFITM3	0.976	0.224744186047
TMEM128	RTN2	0.974	0.076
RTN3	RABAC1	0.974	0.15
RTN3	TMEM170A	0.974
TMEM170A	FAM241A	0.974
MOG	FAM241A	0.974
TMEM208	IFITM3	0.974	0.078
RTN3	MOG	0.973
FAM210B	PRAF2	0.972	0.08
FAM210B	FAM241A	0.972	0.094
ARL6IP5	PRRT1	0.971
FAM241A	IFITM3	0.971	0.088
TMEM68	RTN3	0.97	0.076
RABAC1	FAM241A	0.969	0.054
RTN1	RTN3	0.969	0.276
REEP5	PILRB	0.967		structurally_consistent (dimer)
REEP5	TMEM170A	0.967
RTN3	PILRB	0.966
PRRT1	REEP6	0.966
SVOPL	RTN4	0.965
REEP6	HSD17B2	0.964
REEP6	TMEM170A	0.964
PILRB	RTN4	0.962
REEP6	FAM241B	0.962
REEP6	PILRB	0.961		mutually_exclusive (Q00765)
REEP6	MOG	0.961
HSD17B2	REEP5	0.96	0.074
REEP6	FAM210B	0.96
FAM241A	ARL6IP1	0.96	0.068
REEP5	RTN2	0.959	0.04
REEP6	RTN2	0.958
ARL6IP1	RTN2	0.958	0.046
REEP6	TMEM68	0.957
REEP5	MOG	0.957
RABAC1	IFITM3	0.956	0.188
IFITM3	RTN2	0.955	0.0711818181818
FAM241B	RTN2	0.953	0.048
TMEM128	RTN4	0.946	0.158
TMEM68	RTN4	0.943	0.146
FAM241A	PRAF2	0.942	0.046
ARL6IP5	TMEM170A	0.942
TMEM128	RABAC1	0.94	0.096
RABAC1	RTN2	0.938	0.064
RTN1	FAM210B	0.937	0.07
ARL6IP5	TMEM128	0.933	0.078
TMEM208	FAM241A	0.932	0.074
FAM241B	TMEM170A	0.927
REEP5	RTN3	0.92	0.182
FAM241B	PILRB	0.919
RABAC1	TMEM208	0.914	0.186
FAM210B	FAM241B	0.911	0.076
RTN1	ARL6IP1	0.896	0.158
TMEM128	RTN3	0.894	0.13
RABAC1	ARL6IP1	0.893	0.186
PRRT1	FAM241B	0.891
ARL6IP5	ARL6IP1	0.89	0.09
FAM210B	RTN2	0.886	0.076
ARL6IP5	RABAC1	0.876	0.058
TMEM128	FAM241B	0.869	0.092
RTN1	RABAC1	0.864	0.03
ARL6IP5	TMEM208	0.86	0.0562716049383
RTN1	ARL6IP5	0.84	0.112
SVOPL	FAM241A	0.83
MOG	RTN4	0.83
REEP6	RTN4	0.821
REEP6	PRAF2	0.811
TMEM68	ARL6IP1	0.81	0.148
ARL6IP5	RTN2	0.808	0.07
FAM210B	RABAC1	0.805	0.116
TMEM68	RTN2	0.787	0.05
FAM241B	PRAF2	0.784	0.058
TMEM68	FAM210B	0.771	0.146
RABAC1	PRAF2	0.771	0.108
ARL6IP5	MOG	0.766
ARL6IP5	REEP6	0.762
SCAMP4	FAM241B	0.76	0.044
TMEM68	PRAF2	0.744	0.116
TMEM68	FAM241B	0.74	0.082
SCAMP4	TMEM208	0.73	0.08
TMEM68	SCAMP4	0.726	0.068
REEP6	ARL6IP1	0.717
HSD17B2	IFITM3	0.711
FAM210B	SCAMP4	0.709	0.07
SCAMP4	RABAC1	0.701	0.152
FAM241B	ARL6IP1	0.7	0.052
SCAMP4	PRAF2	0.696	0.034
SCAMP4	FAM241A	0.68	0.066
TMEM68	FAM241A	0.68	0.142
REEP6	RABAC1	0.675
TMEM68	RABAC1	0.659	0.116
ARL6IP5	PRAF2	0.655	0.094	structurally_consistent (dimer)
PRRT1	FAM241A	0.638
ARL6IP5	HSD17B2	0.625	0.07
FAM241B	RABAC1	0.621	0.11
SVOPL	REEP6	0.617
TMEM208	PRAF2	0.613	0.05
SCAMP4	IFITM3	0.587	0.08
RTN1	TMEM68	0.533	0.084
RTN1	TMEM128	0.521	0.094
TMEM68	TMEM208	0.518	0.048
RTN1	REEP6	0.506
ARL6IP5	TMEM68	0.463	0.11
SVOPL	RTN2	0.462
ARL6IP1	PRAF2	0.405	0.068
PRRT1	RTN4	0.398
ARL6IP5	FAM210B	0.38	0.104
FAM210B	ARL6IP1	0.371	0.056
FAM210B	IFITM3	0.36	0.108
TMEM68	IFITM3	0.354	0.126
REEP5	ARL6IP1	0.348	0.138
FAM210B	TMEM208	0.345	0.074
RTN3	PRAF2	0.322	0.084
PRAF2	RTN2	0.289	0.044
SVOPL	RTN3	0.23
RTN1	FAM241B	0.212	0.104
RTN1	TMEM208	0.198	0.078
SVOPL	ARL6IP5	0.176
TMEM208	RTN2	0.17	0.048
FAM241B	IFITM3	0.169	0.048
TMEM208	ARL6IP1	0.152	0.0728888888889
FAM210B	RTN3	0.139	0.098
SVOPL	REEP5	0.112
ARL6IP5	SCAMP4	0.094	0.022
RTN1	REEP5	0.084	0.168
RTN1	PRRT1	0.078
PRRT1	RTN2	0.076
SCAMP4	ARL6IP1	0.076	0.06
PRRT1	RABAC1	0.076
PRRT1	FAM210B	0.076
PRRT1	RTN3	0.065
PRRT1	REEP5	0.059
PRRT1	IFITM3	0.042
RTN1	PRAF2	0.036	0.048
TMEM128	ARL6IP1	0.024	0.13
TMEM128	PRAF2	0.022	0.056
TMEM128	TMEM68	0.02	0.17
TMEM128	FAM241A	0.019	0.108
TMEM170A	RTN4	0.017
RTN1	SCAMP4	0.016	0.034
SCAMP4	RTN4	0.012	0.098
SCAMP4	RTN3	0.006	0.072

Related Complexes

Genename	Complexes
FAM241A	huMAP3_04746.1 huMAP3_06544.1 huMAP3_08599.1 huMAP3_09577.1 huMAP3_09584.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_13957.1 huMAP3_14009.1
TMEM208	huMAP3_02583.1 huMAP3_05992.1 huMAP3_06544.1 huMAP3_08380.1 huMAP3_09577.1 huMAP3_09584.1 huMAP3_10191.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_14009.1
PRAF2	huMAP3_05317.1 huMAP3_06544.1 huMAP3_07819.1 huMAP3_08063.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_13509.1 huMAP3_14009.1
SCAMP4	huMAP3_01871.1 huMAP3_02162.1 huMAP3_04385.1 huMAP3_05317.1 huMAP3_05742.1 huMAP3_06544.1 huMAP3_08380.1 huMAP3_09577.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_13148.1 huMAP3_13778.1 huMAP3_14009.1
TMEM170A	huMAP3_03504.1 huMAP3_04746.1 huMAP3_06544.1 huMAP3_08699.1 huMAP3_09577.1 huMAP3_10255.1 huMAP3_10713.1 huMAP3_10855.1 huMAP3_12924.1 huMAP3_14009.1
REEP6	huMAP3_01797.1 huMAP3_02162.1 huMAP3_05742.1 huMAP3_06544.1 huMAP3_08699.1 huMAP3_08799.1 huMAP3_09577.1 huMAP3_09584.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_13148.1 huMAP3_14009.1
RABAC1	huMAP3_02368.1 huMAP3_05344.1 huMAP3_06544.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_11714.1 huMAP3_14009.1
TMEM68	huMAP3_01797.1 huMAP3_06544.1 huMAP3_08699.1 huMAP3_09482.1 huMAP3_09577.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_14009.1
ARL6IP1	huMAP3_05077.1 huMAP3_05344.1 huMAP3_06544.1 huMAP3_06663.1 huMAP3_08214.1 huMAP3_09139.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_14009.1
REEP5	huMAP3_01871.1 huMAP3_05317.1 huMAP3_06544.1 huMAP3_08380.1 huMAP3_09577.1 huMAP3_09584.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_14009.1
RTN3	huMAP3_02077.1 huMAP3_06544.1 huMAP3_08380.1 huMAP3_09577.1 huMAP3_09584.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_14009.1
TMEM128	huMAP3_01152.1 huMAP3_01871.1 huMAP3_02583.1 huMAP3_05317.1 huMAP3_05992.1 huMAP3_06204.1 huMAP3_06544.1 huMAP3_09535.1 huMAP3_10030.1 huMAP3_10191.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_12182.1 huMAP3_12924.1 huMAP3_14009.1
SVOPL	huMAP3_00426.1 huMAP3_05344.1 huMAP3_05661.1 huMAP3_08063.1 huMAP3_08214.1 huMAP3_09139.1 huMAP3_10855.1 huMAP3_13417.1 huMAP3_13957.1 huMAP3_14009.1
ARL6IP5	huMAP3_00922.1 huMAP3_06580.1 huMAP3_07742.1 huMAP3_08799.1 huMAP3_09584.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_12924.1 huMAP3_14009.1
PRRT1	huMAP3_00922.1 huMAP3_02162.1 huMAP3_05742.1 huMAP3_06580.1 huMAP3_07742.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_12924.1 huMAP3_13148.1 huMAP3_14009.1
FAM241B	huMAP3_02077.1 huMAP3_05344.1 huMAP3_06544.1 huMAP3_08380.1 huMAP3_08599.1 huMAP3_09577.1 huMAP3_09584.1 huMAP3_10255.1 huMAP3_10855.1
RTN4	huMAP3_05077.1 huMAP3_05344.1 huMAP3_05563.1 huMAP3_05661.1 huMAP3_08063.1 huMAP3_08214.1 huMAP3_08799.1 huMAP3_09139.1 huMAP3_09584.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_13417.1 huMAP3_14009.1
HSD17B2	huMAP3_01819.1 huMAP3_01871.1 huMAP3_02162.1 huMAP3_04738.1 huMAP3_04935.1 huMAP3_05317.1 huMAP3_06544.1 huMAP3_06842.1 huMAP3_07941.1 huMAP3_08232.1 huMAP3_08380.1 huMAP3_08471.1 huMAP3_09577.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_13451.1 huMAP3_14009.1 huMAP3_14690.1
RTN1	huMAP3_00278.1 huMAP3_05344.1 huMAP3_06544.1 huMAP3_06894.1 huMAP3_08799.1 huMAP3_09584.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_14009.1
PILRB	huMAP3_04089.1 huMAP3_04746.1 huMAP3_06544.1 huMAP3_07490.1 huMAP3_08380.1 huMAP3_09488.1 huMAP3_09577.1 huMAP3_09584.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_11095.1
FAM210B	huMAP3_01871.1 huMAP3_05317.1 huMAP3_05661.1 huMAP3_06544.1 huMAP3_08063.1 huMAP3_08380.1 huMAP3_09577.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_12230.1 huMAP3_13099.1 huMAP3_14009.1
RTN2	huMAP3_06544.1 huMAP3_08214.1 huMAP3_08799.1 huMAP3_09577.1 huMAP3_09584.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_14009.1
IFITM3	huMAP3_05344.1 huMAP3_05563.1 huMAP3_08358.1 huMAP3_08599.1 huMAP3_09584.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_14009.1 huMAP3_14716.1
MOG	huMAP3_02162.1 huMAP3_04746.1 huMAP3_06544.1 huMAP3_06658.1 huMAP3_08699.1 huMAP3_09577.1 huMAP3_10255.1 huMAP3_10855.1 huMAP3_13050.1 huMAP3_14009.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10855.1

Complex Portal: CPX-11439