hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10857.1

Complex Portal: CPX-15250

Confidence: Medium High

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Genename	Protein Name	Uniprot Annotation Score	Links
DMWD	Dystrophia myotonica WD repeat-containing protein (Dystrophia myotonica-containing WD repeat motif protein) (Protein 59) (Protein DMR-N9)	5	UniProt NCBI
DNAAF11	Dynein axonemal assembly factor 11 (DNAAF11) (Leucine-rich repeat-containing protein 6) (Leucine-rich testis-specific protein) (Protein tilB homolog) (Testis-specific leucine-rich repeat protein)	5	UniProt NCBI
PHLPP1	PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)	5	UniProt NCBI
PHLPP2	PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like)	5	UniProt NCBI
SGO1	Shugoshin 1 (Serologically defined breast cancer antigen NY-BR-85) (Shugoshin-like 1)	5	UniProt NCBI
USP12	Ubiquitin carboxyl-terminal hydrolase 12 (EC 3.4.19.12) (Deubiquitinating enzyme 12) (Ubiquitin thioesterase 12) (Ubiquitin-hydrolyzing enzyme 1) (Ubiquitin-specific-processing protease 12)	5	UniProt NCBI
USP46	Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46)	5	UniProt NCBI
WDR20	WD repeat-containing protein 20 (Protein DMR)	5	UniProt NCBI
WDR48	WD repeat-containing protein 48 (USP1-associated factor 1) (WD repeat endosomal protein) (p80)	5	UniProt NCBI

Showing 1 to 9 of 9 entries

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Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6634	1.31072783286e-08	0.333333333333	WDR20 USP12 WDR48	WDR20-USP12-UAF1 complex
CORUM:6635	1.31072783286e-08	0.333333333333	WDR20 WDR48 USP46	WDR20-USP46-UAF1 complex
CORUM:6521	4.58189849981e-07	0.333333333333	PHLPP1 PHLPP2 WDR48	Akt-PHLPP1-PHLPP2-FANCI-FANCD2-USP1-UAF1 complex
CORUM:6636	2.73623797451e-05	0.222222222222	USP12 WDR48	USP12-UAF1 complex
CORUM:6637	2.73623797451e-05	0.222222222222	USP46 WDR48	USP46-UAF1 complex
GO:0035800	8.06911104389e-05	0.333333333333	DMWD WDR48 WDR20	deubiquitinase activator activity
REAC:R-HSA-5689880	0.0335032070081	0.333333333333	WDR20 USP12 WDR48	Ub-specific processing proteases

Showing 1 to 7 of 7 entries

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Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
WDR20	WDR48	1.0	0.144		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 gupta_WMM boldt_WMM
WDR20	USP46	1.0	0.232	mutually_exclusive (O75317) structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM
WDR48	USP46	0.998	0.224		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM
WDR48	USP12	0.997	0.082	structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM gupta_WMM WMM_only boldt_WMM
WDR20	USP12	0.994	0.152	structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only
WDR20	PHLPP2	0.993			bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only
DNAAF11	PHLPP2	0.992			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
USP46	PHLPP2	0.988			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM
PHLPP1	USP46	0.984	0.054		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
WDR48	DMWD	0.983	0.092		hein_WMM bioplex_WMM bioplex3_WMM hein ()

Showing 1 to 10 of 26 entries

Related Complexes

Genename	Complexes
SGO1	huMAP3_01237.1 huMAP3_03020.1 huMAP3_06695.1 huMAP3_07598.1 huMAP3_07998.1 huMAP3_08607.1 huMAP3_08735.1 huMAP3_09502.1 huMAP3_09689.1 huMAP3_09709.1 huMAP3_10333.1 huMAP3_10857.1 huMAP3_12501.1 huMAP3_13510.1
PHLPP2	huMAP3_04366.1 huMAP3_08086.1 huMAP3_10857.1 huMAP3_12501.1 huMAP3_14529.1
USP12	huMAP3_08607.1 huMAP3_08735.1 huMAP3_09502.1 huMAP3_09689.1 huMAP3_09867.1 huMAP3_10857.1 huMAP3_11019.1 huMAP3_12501.1 huMAP3_14529.1
DMWD	huMAP3_05526.1 huMAP3_08735.1 huMAP3_09502.1 huMAP3_10588.1 huMAP3_10857.1 huMAP3_12229.1 huMAP3_12501.1 huMAP3_14529.1
WDR20	huMAP3_01237.1 huMAP3_01746.1 huMAP3_07598.1 huMAP3_08607.1 huMAP3_08735.1 huMAP3_09502.1 huMAP3_09689.1 huMAP3_10588.1 huMAP3_10857.1 huMAP3_12501.1 huMAP3_14529.1
DNAAF11	huMAP3_04366.1 huMAP3_08086.1 huMAP3_10857.1 huMAP3_12501.1 huMAP3_14529.1
WDR48	huMAP3_01746.1 huMAP3_07921.1 huMAP3_08735.1 huMAP3_09502.1 huMAP3_09689.1 huMAP3_10588.1 huMAP3_10857.1 huMAP3_12501.1 huMAP3_14529.1
PHLPP1	huMAP3_00691.1 huMAP3_02994.1 huMAP3_07598.1 huMAP3_08203.1 huMAP3_08607.1 huMAP3_08735.1 huMAP3_09502.1 huMAP3_09689.1 huMAP3_10509.1 huMAP3_10857.1 huMAP3_12501.1 huMAP3_14529.1 huMAP3_14964.1 huMAP3_15011.1
USP46	huMAP3_01746.1 huMAP3_02994.1 huMAP3_05526.1 huMAP3_07921.1 huMAP3_08735.1 huMAP3_09502.1 huMAP3_09689.1 huMAP3_10588.1 huMAP3_10857.1 huMAP3_12501.1 huMAP3_14529.1