hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10861.1
Complex Portal: CPX-24492
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAP3K2 | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | 5 | UniProt NCBI |
| MAP2K5 | Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5) | 5 | UniProt NCBI |
| MAPK7 | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | 5 | UniProt NCBI |
| MAP3K3 | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | 5 | UniProt NCBI |
| ABL1 | Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP437 | 5.44119195901e-09 | 1.0 | ABL1 MAP2K5 MAP3K2 MAP3K3 MAPK7 | EGF EGFR signaling pathway |
| KEGG:04722 | 4.98230154964e-07 | 0.8 | MAP2K5 MAPK7 ABL1 MAP3K3 | Neurotrophin signaling pathway |
| WP:WP3915 | 1.09625266786e-06 | 0.8 | MAP2K5 MAP3K2 MAP3K3 MAPK7 | Angiopoietin like protein 8 regulatory pathway |
| WP:WP481 | 2.73945122108e-06 | 0.8 | MAP2K5 MAP3K2 MAP3K3 MAPK7 | Insulin signaling |
| REAC:R-HSA-198765 | 1.52013220806e-05 | 0.4 | MAP2K5 MAPK7 | Signalling to ERK5 |
| KEGG:04010 | 1.78654941634e-05 | 0.8 | MAP2K5 MAP3K2 MAP3K3 MAPK7 | MAPK signaling pathway |
| KEGG:04912 | 4.64569454207e-05 | 0.6 | MAP3K2 MAP3K3 MAPK7 | GnRH signaling pathway |
| KEGG:04540 | 5.29656493174e-05 | 0.6 | MAP2K5 MAP3K2 MAPK7 | Gap junction |
| WP:WP5087 | 0.000127149559662 | 0.8 | MAP2K5 MAP3K2 MAP3K3 MAPK7 | Pleural mesothelioma |
| WP:WP2380 | 0.000360939526928 | 0.6 | MAP2K5 MAP3K2 MAPK7 | Brain derived neurotrophic factor BDNF signaling pathway |
| GO:0004672 | 0.00120957367552 | 1.0 | ABL1 MAP2K5 MAP3K2 MAP3K3 MAPK7 | protein kinase activity |
| WP:WP382 | 0.00157746248845 | 0.6 | MAP2K5 MAP3K2 MAPK7 | MAPK signaling pathway |
| CORUM:5199 | 0.00163488349218 | 0.4 | MAP2K5 MAP3K3 | Kinase maturation complex 1 |
| WP:WP422 | 0.00205749802636 | 0.4 | MAP3K2 MAP3K3 | MAPK cascade |
| GO:0016773 | 0.00322776192645 | 1.0 | ABL1 MAP2K5 MAP3K2 MAP3K3 MAPK7 | phosphotransferase activity, alcohol group as acceptor |
| GO:0016301 | 0.00459458827669 | 1.0 | ABL1 MAP2K5 MAP3K2 MAP3K3 MAPK7 | kinase activity |
| WP:WP2795 | 0.00503666229327 | 0.4 | MAP2K5 MAPK7 | Cardiac hypertrophic response |
| WP:WP195 | 0.00659312941575 | 0.4 | MAP3K2 MAP3K3 | IL 1 signaling pathway |
| GO:0016772 | 0.0119931908441 | 1.0 | ABL1 MAP2K5 MAP3K2 MAP3K3 MAPK7 | transferase activity, transferring phosphorus-containing groups |
| WP:WP1544 | 0.0136728736547 | 0.4 | MAP2K5 MAPK7 | MicroRNAs in cardiomyocyte hypertrophy |
| WP:WP185 | 0.020275205407 | 0.4 | MAP2K5 MAPK7 | Integrin mediated cell adhesion |
| WP:WP3931 | 0.0287269200827 | 0.4 | MAP2K5 MAPK7 | Embryonic stem cell pluripotency pathways |
| KEGG:05418 | 0.0303640260346 | 0.4 | MAP2K5 MAPK7 | Fluid shear stress and atherosclerosis |
| KEGG:04921 | 0.03088329966 | 0.4 | MAP2K5 MAPK7 | Oxytocin signaling pathway |
| GO:0071499 | 0.0468008499735 | 0.4 | MAP2K5 MAPK7 | cellular response to laminar fluid shear stress |
| KEGG:05206 | 0.0484667159694 | 0.4 | MAPK7 ABL1 | MicroRNAs in cancer |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAP2K5 | MAPK7 | 0.996 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MAP3K2 | MAP2K5 | 0.995 | 0.192 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MAP3K3 | MAP2K5 | 0.994 | 0.082 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MAP3K3 | MAP3K2 | 0.986 | 0.16 |
mutually_exclusive (Q13163)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM |
| MAP3K3 | ABL1 | 0.979 | 0.098 | hein_WMM bioplex3_WMM WMM_only | |
| MAP3K3 | MAPK7 | 0.487 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only | |
| MAP3K2 | MAPK7 | 0.487 | 0.12 | bioplex_WMM bioplex3_WMM WMM_only | |
| ABL1 | MAP3K2 | 0.428 | 0.046 | bioplex3_WMM WMM_only |
Related Complexes