hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10863.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GPC5 | Glypican-5 [Cleaved into: Secreted glypican-5] | 5 | UniProt NCBI |
| HSPG2 | Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide] | 5 | UniProt NCBI |
| FXYD6 | FXYD domain-containing ion transport regulator 6 (Phosphohippolin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3656253 | 0.000620139908703 | 0.666666666667 | GPC5 HSPG2 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS |
| REAC:R-HSA-3656237 | 0.000620139908703 | 0.666666666667 | GPC5 HSPG2 | Defective EXT2 causes exostoses 2 |
| REAC:R-HSA-9694614 | 0.000926675585137 | 0.666666666667 | GPC5 HSPG2 | Attachment and Entry |
| REAC:R-HSA-4420332 | 0.00104246243986 | 0.666666666667 | GPC5 HSPG2 | Defective B3GALT6 causes EDSP2 and SEMDJL1 |
| REAC:R-HSA-3560801 | 0.00104246243986 | 0.666666666667 | GPC5 HSPG2 | Defective B3GAT3 causes JDSSDHD |
| REAC:R-HSA-3560783 | 0.00104246243986 | 0.666666666667 | GPC5 HSPG2 | Defective B4GALT7 causes EDS, progeroid type |
| REAC:R-HSA-2024096 | 0.00157362645287 | 0.666666666667 | GPC5 HSPG2 | HS-GAG degradation |
| REAC:R-HSA-1971475 | 0.00188000535098 | 0.666666666667 | GPC5 HSPG2 | A tetrasaccharide linker sequence is required for GAG synthesis |
| REAC:R-HSA-2022928 | 0.00257431960226 | 0.666666666667 | GPC5 HSPG2 | HS-GAG biosynthesis |
| REAC:R-HSA-9772572 | 0.00359505378021 | 0.666666666667 | GPC5 HSPG2 | Early SARS-CoV-2 Infection Events |
| REAC:R-HSA-9679506 | 0.00410096621855 | 1.0 | GPC5 FXYD6 HSPG2 | SARS-CoV Infections |
| REAC:R-HSA-3560782 | 0.00478550282195 | 0.666666666667 | GPC5 HSPG2 | Diseases associated with glycosaminoglycan metabolism |
| REAC:R-HSA-975634 | 0.00530917647079 | 0.666666666667 | GPC5 HSPG2 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 0.00614555007695 | 0.666666666667 | GPC5 HSPG2 | Metabolism of fat-soluble vitamins |
| REAC:R-HSA-1793185 | 0.00704293704569 | 0.666666666667 | GPC5 HSPG2 | Chondroitin sulfate/dermatan sulfate metabolism |
| REAC:R-HSA-1638091 | 0.00833431912959 | 0.666666666667 | GPC5 HSPG2 | Heparan sulfate/heparin (HS-GAG) metabolism |
| REAC:R-HSA-2187338 | 0.0204048321881 | 0.666666666667 | GPC5 HSPG2 | Visual phototransduction |
| REAC:R-HSA-9824446 | 0.0269033233908 | 1.0 | GPC5 FXYD6 HSPG2 | Viral Infection Pathways |
| REAC:R-HSA-1630316 | 0.0406752460979 | 0.666666666667 | GPC5 HSPG2 | Glycosaminoglycan metabolism |
| REAC:R-HSA-3781865 | 0.0421708333427 | 0.666666666667 | GPC5 HSPG2 | Diseases of glycosylation |
| REAC:R-HSA-5663205 | 0.0499835710674 | 1.0 | GPC5 FXYD6 HSPG2 | Infectious disease |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GPC5 | HSPG2 | 0.988 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GPC5 | FXYD6 | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| FXYD6 | HSPG2 | 0.046 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| GPC5 | huMAP3_01093.1 huMAP3_06389.1 huMAP3_09762.1 huMAP3_10863.1 huMAP3_13757.1 |
| HSPG2 | huMAP3_09762.1 huMAP3_10863.1 huMAP3_11707.1 |
| FXYD6 | huMAP3_01093.1 huMAP3_06389.1 huMAP3_08891.1 huMAP3_10863.1 huMAP3_13757.1 |