hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10875.1

Complex Portal: CPX-13862

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
KDM5C	Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C)	5	UniProt NCBI
GTF3C2	General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta)	5	UniProt NCBI
GTF3C5	General transcription factor 3C polypeptide 5 (TF3C-epsilon) (Transcription factor IIIC 63 kDa subunit) (TFIIIC 63 kDa subunit) (TFIIIC63) (Transcription factor IIIC subunit epsilon)	5	UniProt NCBI
GTF3C3	General transcription factor 3C polypeptide 3 (Transcription factor IIIC 102 kDa subunit) (TFIIIC 102 kDa subunit) (TFIIIC102) (Transcription factor IIIC subunit gamma) (TF3C-gamma)	5	UniProt NCBI
GTF3C1	General transcription factor 3C polypeptide 1 (TF3C-alpha) (TFIIIC box B-binding subunit) (Transcription factor IIIC 220 kDa subunit) (TFIIIC 220 kDa subunit) (TFIIIC220) (Transcription factor IIIC subunit alpha)	5	UniProt NCBI
ZNF785	Zinc finger protein 785	5	UniProt NCBI
ZNF688	Zinc finger protein 688	5	UniProt NCBI
BEND3	BEN domain-containing protein 3	5	UniProt NCBI
GTF3C4	General transcription factor 3C polypeptide 4 (EC 2.3.1.48) (TF3C-delta) (Transcription factor IIIC 90 kDa subunit) (TFIIIC 90 kDa subunit) (TFIIIC90) (Transcription factor IIIC subunit delta)	5	UniProt NCBI
PNMA2	Paraneoplastic antigen Ma2 (40 kDa neuronal protein) (Onconeuronal antigen Ma2) (Paraneoplastic neuronal antigen MM2)	5	UniProt NCBI
ZNF764	Zinc finger protein 764	5	UniProt NCBI
CYP24A1	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.15.16) (Cytochrome P450 24A1) (Cytochrome P450-CC24)	5	UniProt NCBI
SMARCAD1	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (EC 3.6.4.12) (ATP-dependent helicase 1) (hHEL1)	5	UniProt NCBI
PDZRN3	E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:1105	1.88171091104e-14	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	transcription factor IIIC multisubunit complex
CORUM:1101	1.88171091104e-14	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	transcription factor IIIC multisubunit complex
CORUM:1113	1.88171091104e-14	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	5S-DNA-TFIIIA-TFIIIC2 subcomplex
CORUM:1106	1.12844696421e-13	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	TFIIIC containing-TOP1-SUB1 complex
CORUM:1114	3.94753678843e-13	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	5S-DNA-TFIIIA-TFIIIC2-TFIIIB subcomplex
GO:0000127	1.08105219171e-10	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	transcription factor TFIIIC complex
GO:0042791	1.08105219171e-10	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	5S class rRNA transcription by RNA polymerase III
GO:0090576	1.00794632731e-09	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	RNA polymerase III transcription regulator complex
GO:0042797	4.5311021153e-09	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	tRNA transcription by RNA polymerase III
REAC:R-HSA-76066	6.59033052985e-09	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	RNA Polymerase III Transcription Initiation From Type 2 Promoter
REAC:R-HSA-76061	6.59033052985e-09	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	RNA Polymerase III Transcription Initiation From Type 1 Promoter
GO:0009304	8.30275522242e-09	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	tRNA transcription
GO:0000995	1.42259861189e-08	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	RNA polymerase III general transcription initiation factor activity
REAC:R-HSA-76046	2.77633541669e-08	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	RNA Polymerase III Transcription Initiation
REAC:R-HSA-749476	5.72994028156e-08	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	RNA Polymerase III Abortive And Retractive Initiation
REAC:R-HSA-74158	5.72994028156e-08	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	RNA Polymerase III Transcription
GO:0009303	2.11453843214e-06	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	rRNA transcription
GO:0006383	3.0192659962e-05	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	transcription by RNA polymerase III
GO:0140223	3.0192659962e-05	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	general transcription initiation factor activity
GO:0098781	0.00165336928213	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	ncRNA transcription
REAC:R-HSA-74160	0.00195155465637	0.571428571429	ZNF785 GTF3C4 GTF3C3 GTF3C5 GTF3C2 ZNF764 ZNF688 GTF3C1	Gene expression (Transcription)
GO:0006399	0.0232009116009	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	tRNA metabolic process
GO:0016072	0.0403242396405	0.357142857143	GTF3C3 GTF3C4 GTF3C2 GTF3C1 GTF3C5	rRNA metabolic process

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
GTF3C5	GTF3C3	1.0	0.97
GTF3C1	GTF3C3	1.0	0.866
GTF3C5	GTF3C1	1.0	0.684
GTF3C4	GTF3C5	1.0	0.558
GTF3C4	GTF3C2	1.0	0.598	structurally_consistent (dimer)
GTF3C3	GTF3C2	1.0	0.522
GTF3C4	GTF3C1	0.999	0.538
GTF3C1	GTF3C2	0.999	0.65
GTF3C4	GTF3C3	0.999	0.63
GTF3C5	GTF3C2	0.998	0.238
GTF3C1	ZNF764	0.998
GTF3C3	ZNF764	0.998
ZNF764	GTF3C2	0.996
ZNF764	KDM5C	0.995
GTF3C3	KDM5C	0.994
PNMA2	GTF3C3	0.994	0.09
GTF3C1	PNMA2	0.993	0.088
ZNF785	BEND3	0.991
GTF3C1	KDM5C	0.99
PDZRN3	ZNF785	0.989
GTF3C4	ZNF764	0.989		structurally_consistent (dimer)
SMARCAD1	ZNF785	0.988
GTF3C4	ZNF785	0.986
GTF3C4	ZNF688	0.984		structurally_consistent (dimer)
GTF3C5	KDM5C	0.984
ZNF785	GTF3C2	0.98
GTF3C1	ZNF785	0.975
ZNF764	SMARCAD1	0.974
CYP24A1	ZNF785	0.97
GTF3C5	PNMA2	0.964	0.13
CYP24A1	ZNF764	0.963
GTF3C3	ZNF785	0.961
GTF3C5	ZNF764	0.952
GTF3C2	KDM5C	0.951
GTF3C5	ZNF785	0.824
GTF3C4	KDM5C	0.775
PNMA2	ZNF785	0.635
PNMA2	GTF3C2	0.584	0.12
GTF3C5	SMARCAD1	0.562	0.16
GTF3C3	SMARCAD1	0.549	0.324
ZNF688	GTF3C2	0.467		mutually_exclusive (Q9UKN8)
ZNF688	GTF3C1	0.467
ZNF688	ZNF764	0.415		mutually_exclusive (Q9UKN8)
CYP24A1	PDZRN3	0.261
GTF3C4	PNMA2	0.253	0.082
ZNF688	GTF3C3	0.249
SMARCAD1	KDM5C	0.243
ZNF688	GTF3C5	0.201
PDZRN3	BEND3	0.198	0.064
CYP24A1	BEND3	0.188
SMARCAD1	BEND3	0.176	0.114
SMARCAD1	GTF3C2	0.168	0.124
PNMA2	BEND3	0.151	0.172
PNMA2	PDZRN3	0.15	0.088
CYP24A1	PNMA2	0.143
GTF3C3	BEND3	0.136	0.08
BEND3	GTF3C2	0.124	0.112
GTF3C1	BEND3	0.109	0.07
CYP24A1	GTF3C1	0.105
GTF3C1	SMARCAD1	0.097	0.162
CYP24A1	SMARCAD1	0.096
CYP24A1	GTF3C2	0.089
SMARCAD1	PDZRN3	0.085	0.03
PNMA2	SMARCAD1	0.066	0.19
CYP24A1	GTF3C3	0.059
CYP24A1	GTF3C4	0.053
CYP24A1	GTF3C5	0.04
GTF3C4	BEND3	0.036	0.138
GTF3C5	PDZRN3	0.036	0.05
GTF3C5	BEND3	0.031	0.074
GTF3C3	PDZRN3	0.029	0.06
PDZRN3	GTF3C2	0.025	0.05
GTF3C4	SMARCAD1	0.023	0.204
PDZRN3	KDM5C	0.02
GTF3C4	PDZRN3	0.01	0.04
GTF3C1	PDZRN3	0.004	0.062

Related Complexes

Genename	Complexes
KDM5C	huMAP3_02445.1 huMAP3_05598.1 huMAP3_05651.1 huMAP3_07997.1 huMAP3_08803.1 huMAP3_09735.1 huMAP3_09865.1 huMAP3_10249.1 huMAP3_10875.1 huMAP3_12568.1 huMAP3_14801.1
GTF3C2	huMAP3_01637.1 huMAP3_08790.1 huMAP3_10875.1
GTF3C5	huMAP3_00436.1 huMAP3_01637.1 huMAP3_08803.1 huMAP3_09865.1 huMAP3_10249.1 huMAP3_10875.1 huMAP3_14801.1
GTF3C3	huMAP3_00436.1 huMAP3_01637.1 huMAP3_08803.1 huMAP3_09865.1 huMAP3_10249.1 huMAP3_10875.1 huMAP3_14801.1
GTF3C1	huMAP3_00436.1 huMAP3_01637.1 huMAP3_08803.1 huMAP3_09865.1 huMAP3_10249.1 huMAP3_10875.1 huMAP3_14801.1
ZNF785	huMAP3_01526.1 huMAP3_02527.1 huMAP3_05598.1 huMAP3_06596.1 huMAP3_07981.1 huMAP3_08274.1 huMAP3_10875.1 huMAP3_14801.1
ZNF688	huMAP3_00337.1 huMAP3_10249.1 huMAP3_10875.1 huMAP3_12845.1 huMAP3_13267.1 huMAP3_13532.1 huMAP3_13752.1 huMAP3_14801.1
BEND3	huMAP3_01526.1 huMAP3_02527.1 huMAP3_06596.1 huMAP3_07981.1 huMAP3_08274.1 huMAP3_10875.1 huMAP3_13002.1
GTF3C4	huMAP3_00337.1 huMAP3_10249.1 huMAP3_10875.1 huMAP3_13752.1 huMAP3_14801.1
PNMA2	huMAP3_00436.1 huMAP3_01637.1 huMAP3_02082.1 huMAP3_04000.1 huMAP3_07519.1 huMAP3_07912.1 huMAP3_08726.1 huMAP3_09865.1 huMAP3_09960.1 huMAP3_10249.1 huMAP3_10403.1 huMAP3_10875.1 huMAP3_11689.1
ZNF764	huMAP3_00495.1 huMAP3_02445.1 huMAP3_05598.1 huMAP3_07997.1 huMAP3_08803.1 huMAP3_09735.1 huMAP3_09865.1 huMAP3_10249.1 huMAP3_10875.1 huMAP3_11486.1 huMAP3_13566.1 huMAP3_14801.1
CYP24A1	huMAP3_00107.1 huMAP3_05459.1 huMAP3_05598.1 huMAP3_07134.1 huMAP3_07729.1 huMAP3_07981.1 huMAP3_09087.1 huMAP3_10334.1 huMAP3_10875.1 huMAP3_12133.1 huMAP3_13468.1
SMARCAD1	huMAP3_00739.1 huMAP3_02749.1 huMAP3_05598.1 huMAP3_07981.1 huMAP3_10393.1 huMAP3_10875.1 huMAP3_11486.1 huMAP3_12648.1 huMAP3_13566.1 huMAP3_14314.1 huMAP3_14801.1
PDZRN3	huMAP3_01526.1 huMAP3_02527.1 huMAP3_05162.1 huMAP3_06596.1 huMAP3_07981.1 huMAP3_08274.1 huMAP3_10606.1 huMAP3_10875.1 huMAP3_11926.1 huMAP3_13645.1 huMAP3_14801.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10875.1

Complex Portal: CPX-13862