hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10877.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PTPRF | Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR) | 5 | UniProt NCBI |
| PI4K2A | Phosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha) | 5 | UniProt NCBI |
| TMEM204 | Transmembrane protein 204 (Claudin-like protein 24) | 4 | UniProt NCBI |
| AXL | Tyrosine-protein kinase receptor UFO (EC 2.7.10.1) (AXL oncogene) | 5 | UniProt NCBI |
| SLC8A1 | Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1) | 5 | UniProt NCBI |
| KCNK18 | Potassium channel subfamily K member 18 (TWIK-related individual potassium channel) (TWIK-related spinal cord potassium channel) | 5 | UniProt NCBI |
| ACVR1 | Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I) | 5 | UniProt NCBI |
| ACVR2B | Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB) | 5 | UniProt NCBI |
| ACVR1B | Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2) | 5 | UniProt NCBI |
| FKBP1B | Peptidyl-prolyl cis-trans isomerase FKBP1B (PPIase FKBP1B) (EC 5.2.1.8) (12.6 kDa FK506-binding protein) (12.6 kDa FKBP) (FKBP-12.6) (FK506-binding protein 1B) (FKBP-1B) (Immunophilin FKBP12.6) (Rotamase) (h-FKBP-12) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0048179 | 8.06911104389e-05 | 0.333333333333 | ACVR1 ACVR2B ACVR1B | activin receptor complex |
| GO:0048185 | 0.000282244947588 | 0.333333333333 | ACVR1 ACVR2B ACVR1B | activin binding |
| GO:0017002 | 0.00045145282213 | 0.333333333333 | ACVR1 ACVR2B ACVR1B | activin receptor activity |
| KEGG:04350 | 0.000843198484996 | 0.333333333333 | ACVR1 ACVR2B ACVR1B | TGF-beta signaling pathway |
| GO:0019199 | 0.00220742322002 | 0.444444444444 | ACVR1 AXL ACVR1B ACVR2B | transmembrane receptor protein kinase activity |
| KEGG:04550 | 0.00221143385778 | 0.333333333333 | ACVR1 ACVR2B ACVR1B | Signaling pathways regulating pluripotency of stem cells |
| REAC:R-HSA-1433617 | 0.00286935042585 | 0.222222222222 | ACVR2B ACVR1B | Regulation of signaling by NODAL |
| GO:0004675 | 0.00292902387419 | 0.333333333333 | ACVR1 ACVR2B ACVR1B | transmembrane receptor protein serine/threonine kinase activity |
| REAC:R-HSA-1502540 | 0.00358554253109 | 0.222222222222 | ACVR2B ACVR1B | Signaling by Activin |
| REAC:R-HSA-5576891 | 0.00368511987685 | 0.333333333333 | SLC8A1 FKBP1B KCNK18 | Cardiac conduction |
| GO:0032925 | 0.00450341440411 | 0.333333333333 | ACVR1 ACVR2B ACVR1B | regulation of activin receptor signaling pathway |
| KEGG:04060 | 0.0096486366018 | 0.333333333333 | ACVR1 ACVR2B ACVR1B | Cytokine-cytokine receptor interaction |
| REAC:R-HSA-1181150 | 0.0121597301349 | 0.222222222222 | ACVR2B ACVR1B | Signaling by NODAL |
| REAC:R-HSA-397014 | 0.0201597775175 | 0.333333333333 | SLC8A1 FKBP1B KCNK18 | Muscle contraction |
| GO:0032924 | 0.0234426873659 | 0.333333333333 | ACVR1 ACVR2B ACVR1B | activin receptor signaling pathway |
| GO:0030501 | 0.0325091721374 | 0.333333333333 | SLC8A1 ACVR2B ACVR1 | positive regulation of bone mineralization |
| GO:0045778 | 0.0478559415828 | 0.333333333333 | SLC8A1 ACVR2B ACVR1 | positive regulation of ossification |
| CORUM:2010 | 0.0499842271994 | 0.111111111111 | AXL | AXL homodimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ACVR1 | ACVR1B | 0.997 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ACVR2B | ACVR1B | 0.994 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ACVR1 | PTPRF | 0.994 | 0.094 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ACVR1 | TMEM204 | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ACVR1 | FKBP1B | 0.989 | 0.046 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ACVR1 | SLC8A1 | 0.989 | 0.052 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PI4K2A | PTPRF | 0.987 | 0.028 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt_WMM WMM_only |
| ACVR2B | ACVR1 | 0.984 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ACVR1 | KCNK18 | 0.981 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ACVR2B | PTPRF | 0.98 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ACVR2B | AXL | 0.978 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ACVR1B | PTPRF | 0.963 | 0.112 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| AXL | ACVR1 | 0.936 | 0.042 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| AXL | TMEM204 | 0.92 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SLC8A1 | FKBP1B | 0.557 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only |
| AXL | ACVR1B | 0.29 | 0.082 | bioplex3_WMM WMM_only |
| AXL | PTPRF | 0.198 | 0.22 | bioplex3_WMM WMM_only |
| SLC8A1 | ACVR1B | 0.109 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only |
| ACVR1B | FKBP1B | 0.109 | 0.112 | bioplex_WMM bioplex3_WMM WMM_only |
| ACVR1B | PI4K2A | 0.106 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only |
| KCNK18 | ACVR1B | 0.094 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| KCNK18 | PTPRF | 0.092 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| FKBP1B | PTPRF | 0.053 | 0.068 | bioplex_WMM bioplex3_WMM WMM_only |
| SLC8A1 | PTPRF | 0.053 | 0.088 | bioplex_WMM bioplex3_WMM WMM_only |
| AXL | SLC8A1 | 0.042 | 0.116 | bioplex3_WMM WMM_only |
| AXL | FKBP1B | 0.042 | 0.084 | bioplex3_WMM WMM_only |
| ACVR2B | PI4K2A | 0.022 | bioplex3_WMM WMM_only | |
| ACVR1 | PI4K2A | 0.019 | 0.066 | bioplex_WMM WMM_only |
| AXL | PI4K2A | 0.013 | 0.176 | bioplex3_WMM WMM_only |
Related Complexes