hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10879.1
Complex Portal: CPX-10927
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KLHL1 | Kelch-like protein 1 | 4 | UniProt NCBI |
| PAMR1 | Inactive serine protease PAMR1 (Peptidase domain-containing protein associated with muscle regeneration 1) (Regeneration-associated muscle protease homolog) | 4 | UniProt NCBI |
| SNX5 | Sorting nexin-5 | 5 | UniProt NCBI |
| SNX6 | Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed] | 5 | UniProt NCBI |
| SNX1 | Sorting nexin-1 | 5 | UniProt NCBI |
| HEPACAM | Hepatic and glial cell adhesion molecule (glialCAM) (Hepatocyte cell adhesion molecule) (Protein hepaCAM) | 5 | UniProt NCBI |
| SNX2 | Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9) | 5 | UniProt NCBI |
| C1orf87 | Uncharacterized protein C1orf87 | 2 | UniProt NCBI |
| SNX32 | Sorting nexin-32 (Sorting nexin-6B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030905 | 3.31539150715e-09 | 0.444444444444 | SNX5 SNX2 SNX1 SNX6 | retromer, tubulation complex |
| KEGG:04144 | 5.71551051965e-06 | 0.555555555556 | SNX32 SNX5 SNX2 SNX1 SNX6 | Endocytosis |
| GO:0030904 | 1.27977713551e-05 | 0.444444444444 | SNX5 SNX2 SNX1 SNX6 | retromer complex |
| CORUM:1058 | 2.73623797451e-05 | 0.222222222222 | SNX6 SNX1 | SNX complex (SNX1, SNX6) |
| GO:0042147 | 3.43989524199e-05 | 0.555555555556 | SNX32 SNX5 SNX2 SNX1 SNX6 | retrograde transport, endosome to Golgi |
| CORUM:1070 | 8.20609246787e-05 | 0.222222222222 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4) |
| CORUM:1096 | 8.20609246787e-05 | 0.222222222222 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, PDGFRA) |
| CORUM:1091 | 0.000164069436391 | 0.222222222222 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, LEPR) |
| CORUM:1093 | 0.000164069436391 | 0.222222222222 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, INSR) |
| CORUM:1095 | 0.000164069436391 | 0.222222222222 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, EGFR) |
| GO:0016482 | 0.000201875580427 | 0.555555555556 | SNX32 SNX5 SNX2 SNX1 SNX6 | cytosolic transport |
| CORUM:657 | 0.000273361732609 | 0.222222222222 | SNX1 SNX2 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) |
| CORUM:1059 | 0.000273361732609 | 0.222222222222 | SNX1 SNX2 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) |
| CORUM:1060 | 0.000273361732609 | 0.222222222222 | SNX1 SNX2 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B) |
| GO:0016197 | 0.00742764346214 | 0.555555555556 | SNX32 SNX5 SNX2 SNX1 SNX6 | endosomal transport |
| CORUM:1072 | 0.0499842271994 | 0.111111111111 | SNX2 | SNX complex (SNX2), oligomeric |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SNX5 | SNX1 | 1.0 | 0.326 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| SNX6 | SNX1 | 1.0 | 0.562 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| SNX1 | SNX2 | 1.0 | 0.378 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| SNX1 | SNX32 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| C1orf87 | SNX5 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| C1orf87 | SNX2 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SNX6 | SNX2 | 0.997 | 0.384 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM youn_WMM gupta_WMM fraction |
| C1orf87 | SNX1 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SNX6 | SNX32 | 0.996 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| C1orf87 | HEPACAM | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| KLHL1 | SNX2 | 0.994 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PAMR1 | SNX1 | 0.992 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SNX2 | SNX32 | 0.987 |
mutually_exclusive (Q9UNH7)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SNX5 | SNX2 | 0.984 | 0.33 |
mutually_exclusive (Q9UNH7)
structurally_consistent (dimer) |
bioplex_WMM Guru bioplex3_WMM youn_WMM gupta_WMM fraction |
| KLHL1 | SNX1 | 0.953 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PAMR1 | SNX32 | 0.902 | bioplex3_WMM WMM_only | ||
| KLHL1 | SNX6 | 0.869 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SNX5 | SNX6 | 0.865 | 0.146 |
mutually_exclusive (O60749)
structurally_consistent (dimer) |
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PAMR1 | SNX5 | 0.86 | bioplex3_WMM WMM_only | ||
| SNX5 | SNX32 | 0.73 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PAMR1 | SNX6 | 0.715 | bioplex3_WMM WMM_only | ||
| PAMR1 | SNX2 | 0.356 | bioplex3_WMM WMM_only | ||
| HEPACAM | SNX5 | 0.29 | bioplex_WMM bioplex3_WMM WMM_only | ||
| HEPACAM | SNX1 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only | ||
| HEPACAM | SNX2 | 0.143 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes