hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10880.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GSTA2 | Glutathione S-transferase A2 (EC 2.5.1.18) (GST HA subunit 2) (GST class-alpha member 2) (GST-gamma) (GSTA2-2) (GTH2) | 5 | UniProt NCBI |
| GSTA4 | Glutathione S-transferase A4 (EC 2.5.1.18) (GST class-alpha member 4) (Glutathione S-transferase A4-4) | 5 | UniProt NCBI |
| GSTA1 | Glutathione S-transferase A1 (EC 2.5.1.18) (13-hydroperoxyoctadecadienoate peroxidase) (EC 1.11.1.-) (Androst-5-ene-3,17-dione isomerase) (EC 5.3.3.-) (GST HA subunit 1) (GST class-alpha member 1) (GST-epsilon) (GSTA1-1) (GTH1) [Cleaved into: Glutathione S-transferase A1, N-terminally processed] | 5 | UniProt NCBI |
| GSTA5 | Glutathione S-transferase A5 (EC 2.5.1.18) (GST class-alpha member 5) (Glutathione S-transferase A5-5) | 4 | UniProt NCBI |
| GIN1 | Gypsy retrotransposon integrase-like protein 1 (GIN-1) (Ty3/Gypsy integrase 1) (Zinc finger H2C2 domain-containing protein) | 3 | UniProt NCBI |
| GSTA3 | Glutathione S-transferase A3 (EC 2.5.1.18) (GST class-alpha member 3) (Glutathione S-transferase A3-3) | 5 | UniProt NCBI |
| STARD6 | StAR-related lipid transfer protein 6 (START domain-containing protein 6) (StARD6) | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-156590 | 1.47137351502e-10 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | Glutathione conjugation |
| KEGG:00480 | 4.16061569296e-10 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | Glutathione metabolism |
| KEGG:05204 | 5.63327623148e-10 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | Chemical carcinogenesis - DNA adducts |
| KEGG:00982 | 6.20739024616e-10 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | Drug metabolism - cytochrome P450 |
| KEGG:00980 | 9.82093964122e-10 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | Metabolism of xenobiotics by cytochrome P450 |
| KEGG:00983 | 1.89279007027e-09 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | Drug metabolism - other enzymes |
| KEGG:01524 | 2.37123968126e-09 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | Platinum drug resistance |
| GO:0004364 | 4.96990184286e-09 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | glutathione transferase activity |
| REAC:R-HSA-156580 | 1.74688815385e-08 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | Phase II - Conjugation of compounds |
| KEGG:05418 | 3.26501808768e-08 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | Fluid shear stress and atherosclerosis |
| WP:WP2884 | 4.53962742762e-08 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | NRF2 pathway |
| GO:0006749 | 5.24421182e-08 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | glutathione metabolic process |
| WP:WP702 | 1.17010450609e-07 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | Metapathway biotransformation Phase I and II |
| KEGG:05225 | 1.54125482701e-07 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | Hepatocellular carcinoma |
| KEGG:05207 | 1.74706871149e-07 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | Chemical carcinogenesis - receptor activation |
| KEGG:05208 | 5.14527568742e-07 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | Chemical carcinogenesis - reactive oxygen species |
| GO:0016765 | 5.39667862976e-07 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| REAC:R-HSA-211859 | 6.48717761862e-07 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | Biological oxidations |
| WP:WP2882 | 2.65609293214e-06 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | Nuclear receptors meta pathway |
| GO:0006805 | 6.92172735894e-06 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | xenobiotic metabolic process |
| GO:0071466 | 2.18300158875e-05 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | cellular response to xenobiotic stimulus |
| KEGG:05200 | 2.69718257825e-05 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | Pathways in cancer |
| GO:0006575 | 3.127887328e-05 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | cellular modified amino acid metabolic process |
| GO:0009410 | 8.04804550787e-05 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | response to xenobiotic stimulus |
| HPA:0400201 | 0.000176187390144 | 0.571428571429 | GSTA2 GSTA4 GSTA3 GSTA1 | rectum; endothelial cells[>=Low] |
| HPA:0151293 | 0.00033765160428 | 0.571428571429 | GSTA2 GSTA4 GSTA3 GSTA1 | duodenum; endocrine cells[High] |
| GO:0006790 | 0.00122093090397 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | sulfur compound metabolic process |
| HPA:0151302 | 0.00133169528606 | 0.571428571429 | GSTA2 GSTA4 GSTA3 GSTA1 | duodenum; enterocytes[>=Medium] |
| HPA:0151292 | 0.00159352134304 | 0.571428571429 | GSTA2 GSTA4 GSTA3 GSTA1 | duodenum; endocrine cells[>=Medium] |
| HPA:0151291 | 0.00216680816082 | 0.571428571429 | GSTA2 GSTA4 GSTA3 GSTA1 | duodenum; endocrine cells[>=Low] |
| WP:WP100 | 0.00241415310408 | 0.285714285714 | GSTA1 GSTA5 | Glutathione metabolism |
| HPA:0151301 | 0.00300989196045 | 0.571428571429 | GSTA2 GSTA4 GSTA3 GSTA1 | duodenum; enterocytes[>=Low] |
| WP:WP5066 | 0.00303405736115 | 0.285714285714 | GSTA2 GSTA1 | FOXA2 pathway |
| HPA:0401331 | 0.00303631589849 | 0.571428571429 | GSTA2 GSTA4 GSTA3 GSTA1 | rectum; mucosal lymphoid cells[>=Low] |
| HPA:0481301 | 0.00348288562775 | 0.571428571429 | GSTA2 GSTA4 GSTA3 GSTA1 | small intestine; enterocytes[>=Low] |
| REAC:R-HSA-1430728 | 0.00383440417299 | 0.857142857143 | GSTA5 GSTA2 STARD6 GSTA4 GSTA1 GSTA3 | Metabolism |
| REAC:R-HSA-9818027 | 0.00455853850403 | 0.285714285714 | GSTA1 GSTA3 | NFE2L2 regulating anti-oxidant/detoxification enzymes |
| KEGG:01100 | 0.00514114776296 | 0.714285714286 | GSTA2 GSTA5 GSTA4 GSTA3 GSTA1 | Metabolic pathways |
| REAC:R-HSA-9748787 | 0.0064914715634 | 0.285714285714 | GSTA2 GSTA1 | Azathioprine ADME |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GSTA1 | GSTA3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GSTA1 | GSTA4 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GSTA2 | GSTA4 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GSTA2 | GSTA5 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GSTA2 | GSTA3 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GSTA2 | GSTA1 | 0.98 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| STARD6 | GSTA4 | 0.967 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| GSTA2 | GIN1 | 0.952 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| GSTA1 | GSTA5 | 0.951 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| GSTA3 | GSTA4 | 0.942 | bioplex_WMM bioplex3_WMM WMM_only | |
| GSTA5 | GSTA4 | 0.891 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| GSTA5 | GSTA3 | 0.582 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| GSTA2 | huMAP3_00096.1 huMAP3_10880.1 huMAP3_13591.1 |
| GSTA4 | huMAP3_05333.1 huMAP3_10880.1 huMAP3_13591.1 |
| GSTA1 | huMAP3_00096.1 huMAP3_10880.1 huMAP3_13591.1 |
| GSTA5 | huMAP3_00096.1 huMAP3_10880.1 huMAP3_11246.1 huMAP3_13591.1 |
| GIN1 | huMAP3_00096.1 huMAP3_10880.1 |
| GSTA3 | huMAP3_00096.1 huMAP3_10880.1 huMAP3_13591.1 |
| STARD6 | huMAP3_05333.1 huMAP3_10880.1 huMAP3_13591.1 |