hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10883.1

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha)	5	UniProt NCBI
PIP4K2B	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta)	5	UniProt NCBI
PIP4K2C	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma)	5	UniProt NCBI
NOS1AP	Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein)	5	UniProt NCBI
C1orf226	Uncharacterized protein C1orf226	2	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-8847453	1.24818407584e-08	0.6	PIP4K2A PIP4K2C PIP4K2B	Synthesis of PIPs in the nucleus
REAC:R-HSA-6811555	2.61984124802e-07	0.6	PIP4K2A PIP4K2C PIP4K2B	PI5P Regulates TP53 Acetylation
GO:0016309	9.61200410764e-07	0.6	PIP4K2A PIP4K2C PIP4K2B	1-phosphatidylinositol-5-phosphate 4-kinase activity
GO:1902635	9.61200410764e-07	0.6	PIP4K2A PIP4K2C PIP4K2B	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
GO:1902633	9.61200410764e-07	0.6	PIP4K2A PIP4K2C PIP4K2B	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process
REAC:R-HSA-6804758	1.26352756558e-05	0.6	PIP4K2A PIP4K2C PIP4K2B	Regulation of TP53 Activity through Acetylation
WP:WP5411	1.3807096837e-05	0.6	PIP4K2A PIP4K2C PIP4K2B	Phosphatidyl inositol phosphate pathway
WP:WP4971	1.3807096837e-05	0.6	PIP4K2A PIP4K2C PIP4K2B	Phosphoinositides metabolism
KEGG:00562	4.05033588721e-05	0.6	PIP4K2A PIP4K2C PIP4K2B	Inositol phosphate metabolism
REAC:R-HSA-1660499	5.03751582702e-05	0.6	PIP4K2A PIP4K2C PIP4K2B	Synthesis of PIPs at the plasma membrane
GO:0016308	5.37995977657e-05	0.6	PIP4K2A PIP4K2C PIP4K2B	1-phosphatidylinositol-4-phosphate 5-kinase activity
KEGG:04070	9.13984227268e-05	0.6	PIP4K2A PIP4K2C PIP4K2B	Phosphatidylinositol signaling system
REAC:R-HSA-1483255	0.00018480745401	0.6	PIP4K2A PIP4K2C PIP4K2B	PI Metabolism
REAC:R-HSA-6811558	0.000200829823911	0.6	PIP4K2A PIP4K2C PIP4K2B	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
REAC:R-HSA-199418	0.000264137476094	0.6	PIP4K2A PIP4K2C PIP4K2B	Negative regulation of the PI3K/AKT network
WP:WP51	0.000406952886642	0.6	PIP4K2A PIP4K2C PIP4K2B	Regulation of actin cytoskeleton
GO:2000786	0.000652677252708	0.6	PIP4K2A PIP4K2C PIP4K2B	positive regulation of autophagosome assembly
KEGG:04810	0.00111331850639	0.6	PIP4K2A PIP4K2C PIP4K2B	Regulation of actin cytoskeleton
GO:0044090	0.00147736290187	0.6	PIP4K2A PIP4K2C PIP4K2B	positive regulation of vacuole organization
GO:0052742	0.00169879277018	0.6	PIP4K2A PIP4K2C PIP4K2B	phosphatidylinositol kinase activity
REAC:R-HSA-5633007	0.00176342488404	0.6	PIP4K2A PIP4K2C PIP4K2B	Regulation of TP53 Activity
GO:0046627	0.00220577099344	0.6	PIP4K2A PIP4K2C PIP4K2B	negative regulation of insulin receptor signaling pathway
GO:1900077	0.00249322401434	0.6	PIP4K2A PIP4K2C PIP4K2B	negative regulation of cellular response to insulin stimulus
REAC:R-HSA-1483257	0.0027382103682	0.6	PIP4K2A PIP4K2C PIP4K2B	Phospholipid metabolism
REAC:R-HSA-1257604	0.00610146618873	0.6	PIP4K2A PIP4K2C PIP4K2B	PIP3 activates AKT signaling
GO:0001727	0.00683974211741	0.6	PIP4K2A PIP4K2C PIP4K2B	lipid kinase activity
GO:2000785	0.00875197805683	0.6	PIP4K2A PIP4K2C PIP4K2B	regulation of autophagosome assembly
REAC:R-HSA-9006925	0.00931456721467	0.6	PIP4K2A PIP4K2C PIP4K2B	Intracellular signaling by second messengers
GO:0046626	0.0102064666638	0.6	PIP4K2A PIP4K2C PIP4K2B	regulation of insulin receptor signaling pathway
GO:1900076	0.0109904490822	0.6	PIP4K2A PIP4K2C PIP4K2B	regulation of cellular response to insulin stimulus
GO:0046854	0.0155155487472	0.6	PIP4K2A PIP4K2C PIP4K2B	phosphatidylinositol phosphate biosynthetic process
GO:0044088	0.016548216138	0.6	PIP4K2A PIP4K2C PIP4K2B	regulation of vacuole organization
REAC:R-HSA-3700989	0.0192283148447	0.6	PIP4K2A PIP4K2C PIP4K2B	Transcriptional Regulation by TP53
GO:0016239	0.0327001087246	0.6	PIP4K2A PIP4K2C PIP4K2B	positive regulation of macroautophagy
GO:1902117	0.0379355065545	0.6	PIP4K2A PIP4K2C PIP4K2B	positive regulation of organelle assembly

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
PIP4K2B	PIP4K2C	1.0	0.014	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM
PIP4K2A	PIP4K2C	1.0	0.0883043478261	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM
PIP4K2A	PIP4K2B	1.0	0.318	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM
PIP4K2A	NOS1AP	0.997	0.074	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
PIP4K2C	NOS1AP	0.982	0.098	bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
NOS1AP	C1orf226	0.973	0.166	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
PIP4K2B	NOS1AP	0.971	0.042	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
PIP4K2A	C1orf226	0.952	0.104	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PIP4K2C	C1orf226	0.188	0.072	bioplex_WMM bioplex3_WMM WMM_only
PIP4K2B	C1orf226	0.131	0.078	bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
PIP4K2A	huMAP3_00550.1 huMAP3_00708.1 huMAP3_02291.1 huMAP3_02922.1 huMAP3_03481.1 huMAP3_05647.1 huMAP3_06847.1 huMAP3_07416.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13786.1 huMAP3_13857.1 huMAP3_14693.1
PIP4K2B	huMAP3_00550.1 huMAP3_00708.1 huMAP3_02291.1 huMAP3_03481.1 huMAP3_04301.1 huMAP3_06847.1 huMAP3_07416.1 huMAP3_07859.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10753.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13786.1 huMAP3_13857.1
PIP4K2C	huMAP3_01275.1 huMAP3_04301.1 huMAP3_05601.1 huMAP3_05855.1 huMAP3_07416.1 huMAP3_07859.1 huMAP3_08199.1 huMAP3_08289.1 huMAP3_08432.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09657.1 huMAP3_09823.1 huMAP3_10366.1 huMAP3_10611.1 huMAP3_10753.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12214.1 huMAP3_12350.1 huMAP3_13786.1 huMAP3_13857.1
NOS1AP	huMAP3_03481.1 huMAP3_04394.1 huMAP3_06573.1 huMAP3_06847.1 huMAP3_06938.1 huMAP3_07124.1 huMAP3_08199.1 huMAP3_08432.1 huMAP3_08493.1 huMAP3_08874.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09303.1 huMAP3_09607.1 huMAP3_09823.1 huMAP3_10250.1 huMAP3_10469.1 huMAP3_10611.1 huMAP3_10753.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12350.1 huMAP3_13786.1
C1orf226	huMAP3_03481.1 huMAP3_04394.1 huMAP3_06573.1 huMAP3_06847.1 huMAP3_07124.1 huMAP3_08432.1 huMAP3_08715.1 huMAP3_08914.1 huMAP3_09163.1 huMAP3_09303.1 huMAP3_09520.1 huMAP3_09607.1 huMAP3_10250.1 huMAP3_10469.1 huMAP3_10611.1 huMAP3_10883.1 huMAP3_10957.1 huMAP3_11931.1 huMAP3_12350.1 huMAP3_13786.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10883.1