hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10890.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| USP8 | Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) | 5 | UniProt NCBI |
| GAB2 | GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100) | 5 | UniProt NCBI |
| GRAP2 | GRB2-related adapter protein 2 (Adapter protein GRID) (GRB-2-like protein) (GRB2L) (GRBLG) (GRBX) (Grf40 adapter protein) (Grf-40) (Growth factor receptor-binding protein) (Hematopoietic cell-associated adapter protein GrpL) (P38) (Protein GADS) (SH3-SH2-SH3 adapter Mona) | 5 | UniProt NCBI |
| RAPGEF6 | Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2) | 5 | UniProt NCBI |
| PTPN23 | Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9680350 | 0.00572567861867 | 0.4 | GAB2 GRAP2 | Signaling by CSF1 (M-CSF) in myeloid cells |
| REAC:R-HSA-9607240 | 0.00750894366662 | 0.4 | GAB2 GRAP2 | FLT3 Signaling |
| REAC:R-HSA-1433557 | 0.00953234360475 | 0.4 | GAB2 GRAP2 | Signaling by SCF-KIT |
| WP:WP69 | 0.010677250915 | 0.4 | GAB2 GRAP2 | T cell receptor signaling pathway |
| REAC:R-HSA-9006934 | 0.0398305153279 | 0.6 | GAB2 USP8 GRAP2 | Signaling by Receptor Tyrosine Kinases |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PTPN23 | GRAP2 | 1.0 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GAB2 | GRAP2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GRAP2 | USP8 | 0.999 | 0.176 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GAB2 | USP8 | 0.98 | 0.178 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| RAPGEF6 | PTPN23 | 0.973 | 0.056 | hein_WMM bioplex3_WMM youn_WMM WMM_only |
| PTPN23 | USP8 | 0.966 | 0.064 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| GAB2 | PTPN23 | 0.859 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only |
| RAPGEF6 | USP8 | 0.384 | 0.096 | hein_WMM boldt youn_WMM boldt_WMM WMM_only |
| RAPGEF6 | GAB2 | 0.028 | 0.068 | boldt boldt_WMM WMM_only |
Related Complexes