hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10891.1
Complex Portal: CPX-14670
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RARA | Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1) | 5 | UniProt NCBI |
| NR1H4 | Bile acid receptor (Farnesoid X-activated receptor) (Farnesol receptor HRR-1) (Nuclear receptor subfamily 1 group H member 4) (Retinoid X receptor-interacting protein 14) (RXR-interacting protein 14) | 5 | UniProt NCBI |
| RARB | Retinoic acid receptor beta (RAR-beta) (HBV-activated protein) (Nuclear receptor subfamily 1 group B member 2) (RAR-epsilon) | 5 | UniProt NCBI |
| RXRB | Retinoic acid receptor RXR-beta (Nuclear receptor subfamily 2 group B member 2) (Retinoid X receptor beta) | 5 | UniProt NCBI |
| RARG | Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1989781 | 0.00828920325958 | 1.0 | RXRB NR1H4 | PPARA activates gene expression |
| REAC:R-HSA-400206 | 0.00845837067304 | 1.0 | RXRB NR1H4 | Regulation of lipid metabolism by PPARalpha |
| CORUM:5367 | 0.0249718442457 | 0.5 | RXRB | THRB-RXRB complex |
| WP:WP1531 | 0.0373151717536 | 0.5 | RXRB | Vitamin D metabolism |
| WP:WP5397 | 0.0373151717536 | 0.5 | RXRB | Vitamin A1 and A5 X pathways |
| GO:0032104 | 0.0491610756088 | 1.0 | RXRB NR1H4 | regulation of response to extracellular stimulus |
| GO:0032107 | 0.0491610756088 | 1.0 | RXRB NR1H4 | regulation of response to nutrient levels |
| HP:0012688 | 0.0499436884913 | 0.5 | NR1H4 | Abnormality of pineal physiology |
| HP:0012689 | 0.0499436884913 | 0.5 | NR1H4 | Abnormal pineal melatonin secretion |
| HP:0030899 | 0.0499436884913 | 0.5 | NR1H4 | Pruritis on hand |
| HP:0030900 | 0.0499436884913 | 0.5 | NR1H4 | Pruritus on foot |
| HP:0031248 | 0.0499436884913 | 0.5 | NR1H4 | Palmar pruritus |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RARA | RARG | 0.998 |
mutually_exclusive (P28702)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RXRB | NR1H4 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| RARA | RARB | 0.996 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RXRB | RARG | 0.995 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RXRB | RARA | 0.955 | 0.126 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| RXRB | RARB | 0.502 |
mutually_exclusive (P10276)
structurally_consistent (dimer) |
bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes