hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10893.1
Complex Portal: CPX-21939
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PLEKHH2 | Pleckstrin homology domain-containing family H member 2 | 5 | UniProt NCBI |
| WBP2 | WW domain-binding protein 2 (WBP-2) | 5 | UniProt NCBI |
| EVL | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | 5 | UniProt NCBI |
| VASP | Vasodilator-stimulated phosphoprotein (VASP) | 5 | UniProt NCBI |
| PFN2 | Profilin-2 (Profilin II) | 5 | UniProt NCBI |
| ZYX | Zyxin (Zyxin-2) | 5 | UniProt NCBI |
| SLAIN2 | SLAIN motif-containing protein 2 | 5 | UniProt NCBI |
| SESN1 | Sestrin-1 (EC 1.11.1.-) (p53-regulated protein PA26) | 5 | UniProt NCBI |
| TACC3 | Transforming acidic coiled-coil-containing protein 3 (ERIC-1) | 5 | UniProt NCBI |
| ENAH | Protein enabled homolog | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-202433 | 0.000111932688205 | 0.3 | ENAH EVL VASP | Generation of second messenger molecules |
| KEGG:04015 | 0.000160934332541 | 0.4 | ENAH PFN2 EVL VASP | Rap1 signaling pathway |
| GO:0008154 | 0.000418447412602 | 0.5 | ENAH PFN2 VASP PLEKHH2 EVL | actin polymerization or depolymerization |
| GO:0097435 | 0.00108353543432 | 0.7 | PLEKHH2 PFN2 VASP EVL ENAH ZYX SLAIN2 | supramolecular fiber organization |
| GO:0005522 | 0.00138065085968 | 0.3 | ENAH EVL VASP | profilin binding |
| GO:0007015 | 0.00139680063579 | 0.6 | PLEKHH2 PFN2 VASP ENAH ZYX EVL | actin filament organization |
| REAC:R-HSA-376176 | 0.00196369739418 | 0.4 | ENAH PFN2 EVL VASP | Signaling by ROBO receptors |
| GO:0007010 | 0.00200079553388 | 0.8 | PLEKHH2 PFN2 VASP EVL ENAH TACC3 ZYX SLAIN2 | cytoskeleton organization |
| GO:0051493 | 0.00276797925936 | 0.6 | PLEKHH2 PFN2 VASP EVL TACC3 SLAIN2 | regulation of cytoskeleton organization |
| GO:0032273 | 0.00344224325698 | 0.4 | PFN2 EVL SLAIN2 VASP | positive regulation of protein polymerization |
| REAC:R-HSA-202403 | 0.01035862204 | 0.3 | ENAH EVL VASP | TCR signaling |
| GO:0008064 | 0.0125338195416 | 0.4 | PFN2 VASP PLEKHH2 EVL | regulation of actin polymerization or depolymerization |
| GO:0030832 | 0.0143512934017 | 0.4 | PFN2 VASP PLEKHH2 EVL | regulation of actin filament length |
| GO:0030036 | 0.0207394393406 | 0.6 | PLEKHH2 PFN2 VASP ENAH ZYX EVL | actin cytoskeleton organization |
| GO:1902903 | 0.0237835996432 | 0.5 | PFN2 VASP PLEKHH2 SLAIN2 EVL | regulation of supramolecular fiber organization |
| GO:0030029 | 0.0393567503283 | 0.6 | PLEKHH2 PFN2 VASP ENAH ZYX EVL | actin filament-based process |
| CORUM:6731 | 0.0499436884912 | 0.1 | VASP | VASP-CXCR2 complex, CXCL8 stimulated |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EVL | ENAH | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 gupta_WMM fraction | ||
| VASP | ENAH | 1.0 | 0.052 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| EVL | VASP | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction | ||
| EVL | PLEKHH2 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| EVL | PFN2 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ENAH | ZYX | 0.996 | 0.072 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM | |
| PFN2 | SESN1 | 0.994 | 0.086 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TACC3 | ENAH | 0.989 | 0.08 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| TACC3 | VASP | 0.989 | 0.08 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () gupta_WMM | |
| VASP | PFN2 | 0.982 | 0.16 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| TACC3 | SLAIN2 | 0.974 | 0.074 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction | |
| VASP | ZYX | 0.97 | 0.424 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction | |
| WBP2 | VASP | 0.957 | 0.034 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ENAH | PFN2 | 0.952 | 0.156 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | |
| SLAIN2 | VASP | 0.95 | 0.066 | hein_WMM bioplex3_WMM WMM_only | |
| VASP | PLEKHH2 | 0.696 | bioplex3_WMM WMM_only | ||
| TACC3 | EVL | 0.63 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | ||
| WBP2 | PFN2 | 0.563 | 0.118 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PFN2 | PLEKHH2 | 0.443 | bioplex3_WMM youn_WMM WMM_only | ||
| SLAIN2 | ENAH | 0.433 | 0.044 | hein_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| EVL | WBP2 | 0.419 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ENAH | PLEKHH2 | 0.298 | bioplex3_WMM youn_WMM WMM_only | ||
| WBP2 | ENAH | 0.204 | 0.036 | bioplex_WMM bioplex3_WMM WMM_only | |
| WBP2 | ZYX | 0.112 | 0.054 | bioplex_WMM bioplex3_WMM WMM_only | |
| TACC3 | ZYX | 0.059 | 0.122 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| EVL | ZYX | 0.057 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | ||
| ENAH | SESN1 | 0.051 | 0.07 | bioplex3_WMM WMM_only | |
| SLAIN2 | EVL | 0.027 | bioplex3_WMM WMM_only | ||
| ZYX | PLEKHH2 | 0.026 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| ZYX | PFN2 | 0.016 | 0.134 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | |
| VASP | SESN1 | 0.013 | 0.058 | bioplex3_WMM WMM_only | |
| WBP2 | SESN1 | 0.011 | 0.06 | bioplex3_WMM WMM_only | |
| TACC3 | WBP2 | 0.009 | 0.0545714285714 | bioplex_WMM WMM_only | |
| TACC3 | PLEKHH2 | 0.008 | bioplex3_WMM youn_WMM WMM_only | ||
| SLAIN2 | PLEKHH2 | 0.006 | youn_WMM gupta_WMM WMM_only | ||
| TACC3 | PFN2 | 0.005 | 0.124 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| SLAIN2 | ZYX | 0.003 | 0.116 | youn_WMM gupta_WMM fraction | |
| SLAIN2 | PFN2 | 0.002 | 0.04 | youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
Related Complexes