hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10896.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HES1 | Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL) | 5 | UniProt NCBI |
| TLE1 | Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1) | 5 | UniProt NCBI |
| EN1 | Homeobox protein engrailed-1 (Homeobox protein en-1) (Hu-En-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4844 | 0.000492114068528 | 0.666666666667 | HES1 TLE1 | Influence of laminopathies on Wnt signaling |
| KEGG:04330 | 0.00085927513712 | 0.666666666667 | HES1 TLE1 | Notch signaling pathway |
| WP:WP61 | 0.00106952227093 | 0.666666666667 | HES1 TLE1 | Notch signaling pathway |
| WP:WP4879 | 0.00122198206637 | 0.666666666667 | HES1 TLE1 | Overlap between signal transduction pathways contributing to LMNA laminopathies |
| REAC:R-HSA-2122947 | 0.00530917647079 | 0.666666666667 | HES1 TLE1 | NOTCH1 Intracellular Domain Regulates Transcription |
| WP:WP706 | 0.00817907289077 | 0.666666666667 | HES1 EN1 | Sudden infant death syndrome SIDS susceptibility pathways |
| REAC:R-HSA-1980143 | 0.0116360425406 | 0.666666666667 | HES1 TLE1 | Signaling by NOTCH1 |
| CORUM:3120 | 0.0249718442456 | 0.333333333333 | TLE1 | OCT1-OBF1-DNA-TLE1 complex |
| CORUM:3125 | 0.0249718442456 | 0.333333333333 | TLE1 | TLE1 homodimer complex |
| CORUM:3127 | 0.0249718442456 | 0.333333333333 | TLE1 | TLE-Histone H3 complex |
| CORUM:3164 | 0.0249718442456 | 0.333333333333 | TLE1 | HESX1-TLE1 complex |
| HPA:0450622 | 0.0424050554332 | 0.333333333333 | EN1 | skin; secretory cells[>=Medium] |
| WP:WP3593 | 0.0496447587094 | 0.333333333333 | HES1 | MicroRNA for targeting cancer growth and vascularization in glioblastoma |
| CORUM:3124 | 0.0499402709677 | 0.333333333333 | TLE1 | TLE1-TLE2 complex |
| CORUM:3150 | 0.0499402709677 | 0.333333333333 | TLE1 | NK-3-Groucho complex |
| CORUM:6769 | 0.0499402709677 | 0.333333333333 | TLE1 | TBX20-TLE1 repressor complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TLE1 | HES1 | 0.997 | 0.108 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| TLE1 | EN1 | 0.953 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes