hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10900.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PLS3 | Plastin-3 (T-plastin) | 5 | UniProt NCBI |
| LCP1 | Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1) | 5 | UniProt NCBI |
| PLS1 | Plastin-1 (Intestine-specific plastin) (I-plastin) | 5 | UniProt NCBI |
| METTL6 | tRNA N(3)-methylcytidine methyltransferase METTL6 (EC 2.1.1.-) (Methyltransferase-like protein 6) (hMETTL6) | 5 | UniProt NCBI |
| DKK2 | Dickkopf-related protein 2 (Dickkopf-2) (Dkk-2) (hDkk-2) | 4 | UniProt NCBI |
| IDH1 | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH) (IDH1) (EC 1.1.1.42) (Cytosolic NADP-isocitrate dehydrogenase) (IDPc) (NADP(+)-specific ICDH) (Oxalosuccinate decarboxylase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:404 | 0.0249718442456 | 0.25 | IDH1 | Isocitrate dehydrogenase [NADP], cytoplasmic |
| REAC:R-HSA-2978092 | 0.0499436884912 | 0.25 | IDH1 | Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate |
| REAC:R-HSA-389542 | 0.0499436884912 | 0.25 | IDH1 | NADPH regeneration |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PLS1 | PLS3 | 1.0 | 0.198 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| LCP1 | PLS3 | 0.999 | 0.274 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| METTL6 | PLS1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PLS1 | LCP1 | 0.982 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM |
| DKK2 | LCP1 | 0.981 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| IDH1 | PLS3 | 0.956 | 0.264 | bioplex_WMM Guru bioplex3_WMM youn_WMM gupta_WMM fraction boldt_WMM |
| IDH1 | PLS1 | 0.906 | 0.106 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| METTL6 | PLS3 | 0.817 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| IDH1 | LCP1 | 0.011 | 0.166 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| DKK2 | PLS3 | 0.005 | bioplex3_HEK293 WMM_only |
Related Complexes