hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10905.1
Complex Portal: CPX-20639
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PUM2 | Pumilio homolog 2 (Pumilio-2) | 5 | UniProt NCBI |
| UPF1 | Regulator of nonsense transcripts 1 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog) (hUpf1) | 5 | UniProt NCBI |
| RBMS1 | RNA-binding motif, single-stranded-interacting protein 1 (Single-stranded DNA-binding protein MSSP-1) (Suppressor of CDC2 with RNA-binding motif 2) | 5 | UniProt NCBI |
| PUM1 | Pumilio homolog 1 (HsPUM) (Pumilio-1) | 5 | UniProt NCBI |
| SZRD1 | SUZ domain-containing protein 1 (Putative MAPK-activating protein PM18/PM20/PM22) | 3 | UniProt NCBI |
| RBM47 | RNA-binding protein 47 (RNA-binding motif protein 47) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0061158 | 0.000436807598019 | 0.6 | PUM2 UPF1 PUM1 | 3'-UTR-mediated mRNA destabilization |
| GO:0043488 | 0.00194470757803 | 0.8 | PUM2 UPF1 RBM47 PUM1 | regulation of mRNA stability |
| GO:0043487 | 0.00257382782381 | 0.8 | PUM2 UPF1 RBM47 PUM1 | regulation of RNA stability |
| GO:0061013 | 0.00286397125166 | 0.8 | PUM2 UPF1 RBM47 PUM1 | regulation of mRNA catabolic process |
| GO:0006402 | 0.00893796193013 | 0.8 | PUM2 UPF1 RBM47 PUM1 | mRNA catabolic process |
| GO:1903311 | 0.0172160655627 | 0.8 | PUM2 UPF1 RBM47 PUM1 | regulation of mRNA metabolic process |
| GO:0006401 | 0.0199678668185 | 0.8 | PUM2 UPF1 RBM47 PUM1 | RNA catabolic process |
| KEGG:05017 | 0.0346393491085 | 0.4 | PUM2 PUM1 | Spinocerebellar ataxia |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RBM47 | PUM1 | 0.993 | 0.092 | youn () bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| PUM2 | UPF1 | 0.988 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM | ||
| PUM1 | UPF1 | 0.985 | 0.35 | youn () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only | |
| PUM2 | RBM47 | 0.984 | youn () bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | ||
| PUM2 | PUM1 | 0.983 | youn () bioplex_WMM bioplex3_WMM youn_WMM treiber_WMM WMM_only | ||
| RBM47 | UPF1 | 0.98 | 0.07 | youn () bioplex3_HEK293 bioplex3_WMM youn_WMM bioplex3_HCT116 treiber_WMM WMM_only | |
| RBMS1 | UPF1 | 0.972 | 0.2524 | youn () bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| SZRD1 | UPF1 | 0.955 | 0.21 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| PUM2 | RBMS1 | 0.663 | youn () bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| PUM1 | RBMS1 | 0.501 | 0.168 | youn () bioplex_WMM bioplex3_WMM youn_WMM boldt_WMM treiber_WMM WMM_only | |
| RBM47 | RBMS1 | 0.33 | 0.088 | youn () bioplex3_WMM youn_WMM WMM_only | |
| PUM1 | SZRD1 | 0.005 | 0.126 | youn_WMM fraction |
Related Complexes