hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10908.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FPGS | Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase) | 5 | UniProt NCBI |
| HMGCLL1 | 3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic (EC 4.1.3.4) (3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1) (HMGCL-like 1) (Endoplasmic reticulum 3-hydroxy-3-methylglutaryl-CoA lyase) (er-cHL) | 5 | UniProt NCBI |
| HMGCL | Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-77111 | 0.000143154936711 | 0.666666666667 | HMGCLL1 HMGCL | Synthesis of Ketone Bodies |
| KEGG:00650 | 0.000228770921677 | 0.666666666667 | HMGCLL1 HMGCL | Butanoate metabolism |
| REAC:R-HSA-74182 | 0.00024538606603 | 0.666666666667 | HMGCLL1 HMGCL | Ketone body metabolism |
| KEGG:00280 | 0.000788502734463 | 0.666666666667 | HMGCLL1 HMGCL | Valine, leucine and isoleucine degradation |
| GO:0004419 | 0.00140460216025 | 0.666666666667 | HMGCLL1 HMGCL | hydroxymethylglutaryl-CoA lyase activity |
| KEGG:04146 | 0.00153460242624 | 0.666666666667 | HMGCLL1 HMGCL | Peroxisome |
| GO:0046951 | 0.00842684400117 | 0.666666666667 | HMGCLL1 HMGCL | ketone body biosynthetic process |
| GO:0016833 | 0.0140440992017 | 0.666666666667 | HMGCLL1 HMGCL | oxo-acid-lyase activity |
| GO:0006552 | 0.0140440992017 | 0.666666666667 | HMGCLL1 HMGCL | leucine catabolic process |
| GO:1902224 | 0.0140440992017 | 0.666666666667 | HMGCLL1 HMGCL | ketone body metabolic process |
| KEGG:01100 | 0.0189521995452 | 1.0 | HMGCLL1 FPGS HMGCL | Metabolic pathways |
| GO:0006551 | 0.0294899169624 | 0.666666666667 | HMGCLL1 HMGCL | leucine metabolic process |
| GO:0046950 | 0.0294899169624 | 0.666666666667 | HMGCLL1 HMGCL | cellular ketone body metabolic process |
| WP:WP311 | 0.0413734636003 | 0.333333333333 | HMGCL | Ketone bodies synthesis and degradation |
| WP:WP5175 | 0.0413734636003 | 0.333333333333 | HMGCL | Disorders in ketone body synthesis |
| GO:1901605 | 0.042099520671 | 1.0 | HMGCLL1 FPGS HMGCL | alpha-amino acid metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HMGCL | HMGCLL1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FPGS | HMGCL | 0.993 | 0.044 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes