hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10910.1
Confidence: Medium High  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
POMC | Pro-opiomelanocortin (POMC) (Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma (Gamma-MSH); Potential peptide; Corticotropin (Adrenocorticotropic hormone) (ACTH); Melanocyte-stimulating hormone alpha (Alpha-MSH) (Melanotropin alpha); Corticotropin-like intermediary peptide (CLIP); Lipotropin beta (Beta-LPH); Lipotropin gamma (Gamma-LPH); Melanocyte-stimulating hormone beta (Beta-MSH) (Melanotropin beta); Beta-endorphin; Met-enkephalin] | 5 | UniProt   NCBI |
RBL2 | Retinoblastoma-like protein 2 (130 kDa retinoblastoma-associated protein) (p130) (Retinoblastoma-related protein 2) (RBR-2) (pRb2) | 5 | UniProt   NCBI |
E2F5 | Transcription factor E2F5 (E2F-5) | 5 | UniProt   NCBI |
RBL1 | Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1) | 5 | UniProt   NCBI |
TFDP2 | Transcription factor Dp-2 (E2F dimerization partner 2) | 5 | UniProt   NCBI |
E2F1 | Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) | 5 | UniProt   NCBI |
E2F4 | Transcription factor E2F4 (E2F-4) | 5 | UniProt   NCBI |
LIN52 | Protein lin-52 homolog | 3 | UniProt   NCBI |
LIN37 | Protein lin-37 homolog (Antolefinin) | 5 | UniProt   NCBI |
LIN54 | Protein lin-54 homolog (CXC domain-containing protein 1) | 5 | UniProt   NCBI |
E2F2 | Transcription factor E2F2 (E2F-2) | 5 | UniProt   NCBI |
TESMIN | Tesmin (Metallothionein-like 5, testis-specific) (Testis-specific metallothionein-like protein) | 4 | UniProt   NCBI |
MYBL2 | Myb-related protein B (B-Myb) (Myb-like protein 2) | 5 | UniProt   NCBI |
MYBL1 | Myb-related protein A (A-Myb) (Myb-like protein 1) | 5 | UniProt   NCBI |
MCIDAS | Multicilin (Multiciliate differentiation and DNA synthesis-associated cell cycle protein) (McIdas protein) (Protein Idas) | 5 | UniProt   NCBI |
LIN9 | Protein lin-9 homolog (HuLin-9) (hLin-9) (Beta subunit-associated regulator of apoptosis) (TUDOR gene similar protein) (Type I interferon receptor beta chain-associated protein) (pRB-associated protein) | 5 | UniProt   NCBI |
E2F3 | Transcription factor E2F3 (E2F-3) | 5 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  REAC:R-HSA-1362300 | 3.35937684363e-23 | 0.642857142857 | LIN37 E2F1 E2F4 LIN54 RBL1 RBL2 TFDP2 E2F5 LIN9 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
  REAC:R-HSA-1362277 | 3.26037804629e-22 | 0.642857142857 | LIN37 E2F1 E2F4 LIN54 RBL1 RBL2 TFDP2 E2F5 LIN9 | Transcription of E2F targets under negative control by DREAM complex |
  REAC:R-HSA-1538133 | 2.0901098134e-20 | 0.642857142857 | LIN37 E2F1 E2F4 LIN54 RBL1 RBL2 TFDP2 E2F5 LIN9 | G0 and Early G1 |
  REAC:R-HSA-69205 | 3.13419782733e-20 | 0.642857142857 | LIN37 E2F1 E2F4 LIN54 RBL1 RBL2 TFDP2 E2F5 LIN9 | G1/S-Specific Transcription |
  REAC:R-HSA-453279 | 7.26634450357e-18 | 0.785714285714 | E2F3 LIN37 E2F1 E2F4 LIN54 RBL1 E2F2 RBL2 TFDP2 E2F5 LIN9 | Mitotic G1 phase and G1/S transition |
  KEGG:04218 | 2.53102495153e-16 | 0.714285714286 | E2F3 LIN37 E2F1 E2F4 LIN54 RBL1 E2F2 RBL2 E2F5 LIN9 | Cellular senescence |
  REAC:R-HSA-69231 | 4.21272429116e-15 | 0.571428571429 | E2F3 E2F1 E2F4 RBL1 E2F2 RBL2 TFDP2 E2F5 | Cyclin D associated events in G1 |
  REAC:R-HSA-69236 | 4.21272429116e-15 | 0.571428571429 | E2F3 E2F1 E2F4 RBL1 E2F2 RBL2 TFDP2 E2F5 | G1 Phase |
  WP:WP5180 | 6.94949181187e-15 | 0.571428571429 | LIN37 E2F4 LIN54 RBL1 RBL2 TFDP2 E2F5 LIN9 | DYRK1A involvement regarding cell proliferation in brain development |
  CORUM:5596 | 1.12844696421e-13 | 0.357142857143 | LIN37 RBL2 LIN54 LIN9 E2F4 | LINC complex, quiescent cells |
  REAC:R-HSA-69206 | 1.42612715543e-13 | 0.642857142857 | LIN37 E2F1 E2F4 LIN54 RBL1 RBL2 TFDP2 E2F5 LIN9 | G1/S Transition |
  REAC:R-HSA-69202 | 5.67887406218e-13 | 0.571428571429 | LIN37 E2F1 E2F4 LIN54 RBL2 TFDP2 E2F5 LIN9 | Cyclin E associated events during G1/S transition |
  REAC:R-HSA-69656 | 6.94106654788e-13 | 0.571428571429 | LIN37 E2F1 E2F4 LIN54 RBL2 TFDP2 E2F5 LIN9 | Cyclin A:Cdk2-associated events at S phase entry |
  WP:WP179 | 4.14789515762e-12 | 0.571428571429 | E2F3 E2F1 E2F4 RBL1 E2F2 RBL2 TFDP2 E2F5 | Cell cycle |
  REAC:R-HSA-69278 | 1.09855359273e-11 | 0.785714285714 | E2F3 LIN37 E2F1 E2F4 LIN54 RBL1 E2F2 RBL2 TFDP2 E2F5 LIN9 | Cell Cycle, Mitotic |
  KEGG:04110 | 1.70746618998e-11 | 0.571428571429 | E2F3 E2F1 E2F4 RBL1 E2F2 RBL2 TFDP2 E2F5 | Cell cycle |
  REAC:R-HSA-1640170 | 1.0672356957e-10 | 0.785714285714 | E2F3 LIN37 E2F1 E2F4 LIN54 RBL1 E2F2 RBL2 TFDP2 E2F5 LIN9 | Cell Cycle |
  REAC:R-HSA-69242 | 1.31208311403e-10 | 0.571428571429 | LIN37 E2F1 E2F4 LIN54 RBL2 TFDP2 E2F5 LIN9 | S Phase |
  CORUM:5589 | 1.3739312217e-10 | 0.285714285714 | LIN37 RBL1 LIN9 LIN54 | LINC complex, S-phase |
  REAC:R-HSA-6791312 | 1.21214970424e-07 | 0.357142857143 | RBL2 E2F4 E2F1 RBL1 TFDP2 | TP53 Regulates Transcription of Cell Cycle Genes |
  CORUM:5593 | 1.4600392795e-07 | 0.214285714286 | LIN37 LIN9 LIN54 | LINC core complex |
  GO:0005667 | 2.64812524329e-07 | 0.642857142857 | E2F3 E2F1 E2F4 LIN54 RBL1 E2F2 RBL2 TFDP2 E2F5 | transcription regulator complex |
  REAC:R-HSA-6804114 | 3.49673363548e-07 | 0.285714285714 | RBL2 E2F4 RBL1 TFDP2 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest |
  REAC:R-HSA-9661069 | 3.49673363548e-07 | 0.285714285714 | E2F3 TFDP2 E2F1 E2F2 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) |
  REAC:R-HSA-9659787 | 3.49673363548e-07 | 0.285714285714 | E2F3 TFDP2 E2F1 E2F2 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects |
  CORUM:5117 | 3.64803730192e-07 | 0.214285714286 | RBL2 E2F4 E2F5 | RBL2 complex (DNMT1, E2F4, E2F5, HDAC1, SUV39H1, RBL2) |
  CORUM:2975 | 3.64803730192e-07 | 0.214285714286 | E2F5 RBL1 E2F4 | SMAD3-E2F4/5-p107-DP1 complex |
  CORUM:5118 | 7.29195506708e-07 | 0.214285714286 | RBL2 E2F4 E2F5 | RBL2 complex (E2F4, E2F5, HDAC1, SUV39H1, P300, RBL2) |
  CORUM:1474 | 7.29195506708e-07 | 0.214285714286 | E2F5 RBL1 E2F4 | SMAD3/4-E2F4/5-p107-DP1 complex |
  REAC:R-HSA-2559585 | 5.95954170433e-06 | 0.285714285714 | E2F3 TFDP2 E2F1 E2F2 | Oncogene Induced Senescence |
  REAC:R-HSA-9687139 | 7.61729342671e-06 | 0.285714285714 | E2F3 TFDP2 E2F1 E2F2 | Aberrant regulation of mitotic cell cycle due to RB1 defects |
  REAC:R-HSA-2173796 | 8.56475807908e-06 | 0.285714285714 | E2F5 E2F4 RBL1 TFDP2 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
  REAC:R-HSA-9675126 | 9.59764691822e-06 | 0.285714285714 | E2F3 TFDP2 E2F1 E2F2 | Diseases of mitotic cell cycle |
  REAC:R-HSA-2173793 | 3.32294016087e-05 | 0.285714285714 | E2F5 E2F4 RBL1 TFDP2 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
  WP:WP45 | 3.7747322566e-05 | 0.285714285714 | E2F3 TFDP2 E2F1 E2F2 | G1 to S cell cycle control |
  CORUM:5160 | 4.44741811353e-05 | 0.142857142857 | RBL2 E2F4 | E2F4-p130 complex |
  CORUM:5159 | 4.44741811353e-05 | 0.142857142857 | E2F4 RBL1 | E2F4-p107-cyclinE complex |
  GO:0010468 | 5.66599574672e-05 | 1.0 | E2F3 LIN37 E2F4 E2F1 E2F5 LIN54 RBL1 E2F2 RBL2 MCIDAS TFDP2 TESMIN POMC LIN9 | regulation of gene expression |
  GO:0010556 | 8.75853182006e-05 | 1.0 | E2F3 LIN37 E2F4 E2F1 E2F5 LIN54 RBL1 E2F2 RBL2 MCIDAS TFDP2 TESMIN POMC LIN9 | regulation of macromolecule biosynthetic process |
  REAC:R-HSA-156711 | 8.88307161819e-05 | 0.214285714286 | LIN37 LIN9 LIN54 | Polo-like kinase mediated events |
  GO:0031326 | 0.000119189450934 | 1.0 | E2F3 LIN37 E2F4 E2F1 E2F5 LIN54 RBL1 E2F2 RBL2 MCIDAS TFDP2 TESMIN POMC LIN9 | regulation of cellular biosynthetic process |
  WP:WP2446 | 0.000124644595149 | 0.285714285714 | E2F3 TFDP2 E2F1 E2F2 | Retinoblastoma gene in cancer |
  GO:0009889 | 0.000129486701642 | 1.0 | E2F3 LIN37 E2F4 E2F1 E2F5 LIN54 RBL1 E2F2 RBL2 MCIDAS TFDP2 TESMIN POMC LIN9 | regulation of biosynthetic process |
  CORUM:1473 | 0.000133349500201 | 0.142857142857 | RBL2 E2F5 | E2F5-RB2-DP1 complex |
  CORUM:1661 | 0.000133349500201 | 0.142857142857 | E2F4 RBL1 | E2F4-p107-cyclinA complex |
  CORUM:5144 | 0.000133349500201 | 0.142857142857 | RBL1 E2F1 | E2F1-p107-cyclinA complex |
  REAC:R-HSA-453274 | 0.000184892013153 | 0.357142857143 | E2F3 LIN37 E2F1 LIN9 LIN54 | Mitotic G2-G2/M phases |
  KEGG:04934 | 0.000265695773703 | 0.285714285714 | E2F3 E2F2 POMC E2F1 | Cushing syndrome |
  KEGG:05219 | 0.000272745512488 | 0.214285714286 | E2F3 E2F1 E2F2 | Bladder cancer |
  WP:WP236 | 0.000299433472118 | 0.285714285714 | RBL2 E2F4 RBL1 E2F1 | Adipogenesis |
  REAC:R-HSA-170834 | 0.000314712056409 | 0.285714285714 | E2F5 E2F4 RBL1 TFDP2 | Signaling by TGF-beta Receptor Complex |
  CORUM:1471 | 0.000444011791638 | 0.142857142857 | RBL2 E2F5 | pRb2/p130-multimolecular complex (RB2, E2F5, HDAC1, SUV39H1, P300) |
  WP:WP366 | 0.000457715973322 | 0.285714285714 | RBL2 E2F4 RBL1 E2F5 | TGF beta signaling pathway |
  CORUM:6444 | 0.000665653089703 | 0.142857142857 | RBL2 RBL1 | SMAR1-HDAC1-SIN3A-SIN3B-p107-p130 repressor complex |
  REAC:R-HSA-2559580 | 0.000721668312014 | 0.285714285714 | E2F3 TFDP2 E2F1 E2F2 | Oxidative Stress Induced Senescence |
  REAC:R-HSA-9006936 | 0.000749013011324 | 0.285714285714 | E2F5 E2F4 RBL1 TFDP2 | Signaling by TGFB family members |
  GO:0006355 | 0.000788933082668 | 0.857142857143 | E2F3 LIN37 E2F1 E2F4 LIN54 E2F2 E2F5 MCIDAS TFDP2 TESMIN POMC LIN9 | regulation of DNA-templated transcription |
  GO:2001141 | 0.000846654387404 | 0.857142857143 | E2F3 LIN37 E2F1 E2F4 LIN54 E2F2 E2F5 MCIDAS TFDP2 TESMIN POMC LIN9 | regulation of RNA biosynthetic process |
  GO:0090575 | 0.000967961668366 | 0.428571428571 | E2F3 E2F1 E2F4 E2F5 TFDP2 E2F2 | RNA polymerase II transcription regulator complex |
  GO:0006351 | 0.00137134257161 | 0.857142857143 | E2F3 LIN37 E2F1 E2F4 LIN54 E2F2 E2F5 MCIDAS TFDP2 TESMIN POMC LIN9 | DNA-templated transcription |
  KEGG:05218 | 0.00142363582364 | 0.214285714286 | E2F3 E2F1 E2F2 | Melanoma |
  GO:0060255 | 0.00145872195164 | 1.0 | E2F3 LIN37 E2F4 E2F1 E2F5 LIN54 RBL1 E2F2 RBL2 MCIDAS TFDP2 TESMIN POMC LIN9 | regulation of macromolecule metabolic process |
  GO:0031323 | 0.00150774426676 | 1.0 | E2F3 LIN37 E2F4 E2F1 E2F5 LIN54 RBL1 E2F2 RBL2 MCIDAS TFDP2 TESMIN POMC LIN9 | regulation of cellular metabolic process |
  GO:0032774 | 0.00155322980949 | 0.857142857143 | E2F3 LIN37 E2F1 E2F4 LIN54 E2F2 E2F5 MCIDAS TFDP2 TESMIN POMC LIN9 | RNA biosynthetic process |
  KEGG:05214 | 0.00188009856862 | 0.214285714286 | E2F3 E2F1 E2F2 | Glioma |
  KEGG:05223 | 0.00188009856862 | 0.214285714286 | E2F3 E2F1 E2F2 | Non-small cell lung cancer |
  GO:0001067 | 0.0019477802701 | 0.642857142857 | E2F3 E2F1 E2F4 LIN54 RBL1 E2F2 RBL2 TFDP2 E2F5 | transcription regulatory region nucleic acid binding |
  GO:0010467 | 0.00222841955465 | 1.0 | E2F3 LIN37 E2F4 E2F1 E2F5 LIN54 RBL1 E2F2 RBL2 MCIDAS TFDP2 TESMIN POMC LIN9 | gene expression |
  KEGG:05212 | 0.00223233650819 | 0.214285714286 | E2F3 E2F1 E2F2 | Pancreatic cancer |
  REAC:R-HSA-111448 | 0.00238968144039 | 0.142857142857 | TFDP2 E2F1 | Activation of NOXA and translocation to mitochondria |
  REAC:R-HSA-68911 | 0.00238968144039 | 0.142857142857 | E2F3 E2F1 | G2 Phase |
  KEGG:05220 | 0.00242363230796 | 0.214285714286 | E2F3 E2F1 E2F2 | Chronic myeloid leukemia |
  WP:WP4685 | 0.0027024073326 | 0.214285714286 | E2F3 E2F1 E2F2 | Melanoma |
  GO:0051252 | 0.00290276006824 | 0.857142857143 | E2F3 LIN37 E2F1 E2F4 LIN54 E2F2 E2F5 MCIDAS TFDP2 TESMIN POMC LIN9 | regulation of RNA metabolic process |
  GO:0001216 | 0.0030114918032 | 0.428571428571 | E2F3 E2F1 E2F4 E2F5 TFDP2 E2F2 | DNA-binding transcription activator activity |
  REAC:R-HSA-3700989 | 0.0030422249011 | 0.357142857143 | RBL2 E2F4 E2F1 RBL1 TFDP2 | Transcriptional Regulation by TP53 |
  KEGG:01522 | 0.00329612652804 | 0.214285714286 | E2F3 E2F1 E2F2 | Endocrine resistance |
  WP:WP4255 | 0.00376819179791 | 0.214285714286 | E2F3 E2F1 E2F2 | Non small cell lung cancer |
  KEGG:05222 | 0.00380039958933 | 0.214285714286 | E2F3 E2F1 E2F2 | Small cell lung cancer |
  KEGG:04350 | 0.00393390270727 | 0.214285714286 | E2F5 RBL1 E2F4 | TGF-beta signaling pathway |
  GO:0003677 | 0.00431045510111 | 0.714285714286 | E2F3 LIN9 E2F1 E2F4 LIN54 RBL1 E2F2 RBL2 TFDP2 E2F5 | DNA binding |
  KEGG:05215 | 0.00435276586086 | 0.214285714286 | E2F3 E2F1 E2F2 | Prostate cancer |
  GO:0019222 | 0.00480489848175 | 1.0 | E2F3 LIN37 E2F4 E2F1 E2F5 LIN54 RBL1 E2F2 RBL2 MCIDAS TFDP2 TESMIN POMC LIN9 | regulation of metabolic process |
  REAC:R-HSA-2559583 | 0.00508554984912 | 0.285714285714 | E2F3 TFDP2 E2F1 E2F2 | Cellular Senescence |
  REAC:R-HSA-212436 | 0.00508862541941 | 0.5 | E2F4 E2F1 E2F5 RBL1 RBL2 TFDP2 POMC | Generic Transcription Pathway |
  WP:WP53 | 0.0065190163061 | 0.142857142857 | RBL2 RBL1 | ID signaling pathway |
  WP:WP4263 | 0.00665832680083 | 0.214285714286 | E2F3 E2F1 E2F2 | Pancreatic adenocarcinoma pathway |
  GO:0034654 | 0.00667701850949 | 0.857142857143 | E2F3 LIN37 E2F1 E2F4 LIN54 E2F2 E2F5 MCIDAS TFDP2 TESMIN POMC LIN9 | nucleobase-containing compound biosynthetic process |
  GO:0009059 | 0.00703141324807 | 1.0 | E2F3 LIN37 E2F4 E2F1 E2F5 LIN54 RBL1 E2F2 RBL2 MCIDAS TFDP2 TESMIN POMC LIN9 | macromolecule biosynthetic process |
  CORUM:5614 | 0.00753462493182 | 0.142857142857 | RBL2 RBL1 | Emerin complex 32 |
  GO:0018130 | 0.00824679764186 | 0.857142857143 | E2F3 LIN37 E2F1 E2F4 LIN54 E2F2 E2F5 MCIDAS TFDP2 TESMIN POMC LIN9 | heterocycle biosynthetic process |
  GO:0019438 | 0.00834882837684 | 0.857142857143 | E2F3 LIN37 E2F1 E2F4 LIN54 E2F2 E2F5 MCIDAS TFDP2 TESMIN POMC LIN9 | aromatic compound biosynthetic process |
  GO:0019219 | 0.0083830929296 | 0.857142857143 | E2F3 LIN37 E2F1 E2F4 LIN54 E2F2 E2F5 MCIDAS TFDP2 TESMIN POMC LIN9 | regulation of nucleobase-containing compound metabolic process |
  REAC:R-HSA-139915 | 0.00858403131057 | 0.142857142857 | TFDP2 E2F1 | Activation of PUMA and translocation to mitochondria |
  WP:WP4658 | 0.00882246767259 | 0.214285714286 | E2F3 E2F1 E2F2 | Small cell lung cancer |
  REAC:R-HSA-73857 | 0.010433823826 | 0.5 | E2F4 E2F1 E2F5 RBL1 RBL2 TFDP2 POMC | RNA Polymerase II Transcription |
  GO:1901362 | 0.0116697820233 | 0.857142857143 | E2F3 LIN37 E2F1 E2F4 LIN54 E2F2 E2F5 MCIDAS TFDP2 TESMIN POMC LIN9 | organic cyclic compound biosynthetic process |
  KEGG:05224 | 0.012096046058 | 0.214285714286 | E2F3 E2F1 E2F2 | Breast cancer |
  KEGG:05226 | 0.0132550197928 | 0.214285714286 | E2F3 E2F1 E2F2 | Gastric cancer |
  KEGG:05160 | 0.0132550197928 | 0.214285714286 | E2F3 E2F1 E2F2 | Hepatitis C |
  REAC:R-HSA-1912408 | 0.013259733202 | 0.214285714286 | TFDP2 E2F1 E2F3 | Pre-NOTCH Transcription and Translation |
  GO:0006357 | 0.0158136219481 | 0.714285714286 | E2F3 LIN37 E2F1 E2F4 MCIDAS E2F2 E2F5 TFDP2 POMC LIN9 | regulation of transcription by RNA polymerase II |
  REAC:R-HSA-113501 | 0.0185580458088 | 0.142857142857 | TFDP2 E2F1 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
  KEGG:05161 | 0.0189814300125 | 0.214285714286 | E2F3 E2F1 E2F2 | Hepatitis B |
  KEGG:05206 | 0.0189814300125 | 0.214285714286 | E2F3 E2F1 E2F2 | MicroRNAs in cancer |
  GO:0000977 | 0.0214026527122 | 0.571428571429 | E2F3 E2F1 E2F4 RBL1 E2F2 RBL2 TFDP2 E2F5 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
  KEGG:05225 | 0.0234232001825 | 0.214285714286 | E2F3 E2F1 E2F2 | Hepatocellular carcinoma |
  REAC:R-HSA-1912422 | 0.0234730904617 | 0.214285714286 | TFDP2 E2F1 E2F3 | Pre-NOTCH Expression and Processing |
  REAC:R-HSA-74160 | 0.0235063164902 | 0.5 | E2F4 E2F1 E2F5 RBL1 RBL2 TFDP2 POMC | Gene expression (Transcription) |
  WP:000000 | 0.0255572149878 | 0.928571428571 | E2F3 LIN37 E2F4 E2F1 E2F5 LIN54 RBL1 E2F2 RBL2 MCIDAS TFDP2 POMC LIN9 | WIKIPATHWAYS |
  GO:0006366 | 0.0262705597273 | 0.714285714286 | E2F3 LIN37 E2F1 E2F4 MCIDAS E2F2 E2F5 TFDP2 POMC LIN9 | transcription by RNA polymerase II |
  KEGG:05167 | 0.0275177525526 | 0.214285714286 | E2F3 E2F1 E2F2 | Kaposi sarcoma-associated herpesvirus infection |
  WP:WP4262 | 0.0290458239692 | 0.214285714286 | E2F3 E2F1 E2F2 | Breast cancer pathway |
  KEGG:05169 | 0.0336568278998 | 0.214285714286 | E2F3 E2F1 E2F2 | Epstein-Barr virus infection |
  GO:0000785 | 0.0389512163615 | 0.571428571429 | E2F3 E2F1 E2F4 RBL1 E2F2 RBL2 TFDP2 E2F5 | chromatin |
  GO:0016070 | 0.0392907399865 | 0.857142857143 | E2F3 LIN37 E2F1 E2F4 LIN54 E2F2 E2F5 MCIDAS TFDP2 TESMIN POMC LIN9 | RNA metabolic process |
  KEGG:05163 | 0.040612882765 | 0.214285714286 | E2F3 E2F1 E2F2 | Human cytomegalovirus infection |
  GO:0000976 | 0.0411498000101 | 0.571428571429 | E2F3 E2F1 E2F4 RBL1 E2F2 RBL2 TFDP2 E2F5 | transcription cis-regulatory region binding |
  GO:0044249 | 0.0429321940113 | 1.0 | E2F3 LIN37 E2F4 E2F1 E2F5 LIN54 RBL1 E2F2 RBL2 MCIDAS TFDP2 TESMIN POMC LIN9 | cellular biosynthetic process |
  KEGG:05166 | 0.0444106258153 | 0.214285714286 | E2F3 E2F1 E2F2 | Human T-cell leukemia virus 1 infection |
  GO:1901576 | 0.0481113191273 | 1.0 | E2F3 LIN37 E2F4 E2F1 E2F5 LIN54 RBL1 E2F2 RBL2 MCIDAS TFDP2 TESMIN POMC LIN9 | organic substance biosynthetic process |
  WP:WP5202 | 0.0484579411248 | 0.142857142857 | TFDP2 E2F4 | Alstrom syndrome |
  CORUM:839 | 0.0499958217778 | 0.0714285714286 | LIN9 | LIN9-BMYB complex |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD |
---|---|---|---|
 LIN37 |  LIN54 | 1.0 | 0.148           |
 LIN37 |  LIN9 | 1.0 | 0.174           |
 LIN52 |  LIN9 | 1.0 | 0.198           |
 LIN37 |  MYBL2 | 1.0 | 0.164           |
 LIN54 |  LIN9 | 1.0 | 0.324           |
 LIN52 |  LIN37 | 1.0 | 0.18           |
 MYBL2 |  LIN9 | 1.0 | 0.248           |
 MYBL1 |  LIN9 | 0.999 |            |
 LIN37 |  MYBL1 | 0.999 |            |
 LIN52 |  MYBL1 | 0.999 |            |
 E2F4 |  TFDP2 | 0.998 | 0.16           |
 LIN52 |  LIN54 | 0.998 | 0.21           |
 E2F5 |  TFDP2 | 0.998 |            |
 TFDP2 |  E2F2 | 0.997 |            |
 LIN54 |  MYBL1 | 0.997 |            |
 RBL2 |  RBL1 | 0.996 | 0.118           |
 TFDP2 |  E2F3 | 0.996 | 0.152           |
 TFDP2 |  E2F1 | 0.991 |            |
 LIN52 |  MYBL2 | 0.99 | 0.184           |
 MCIDAS |  TFDP2 | 0.985 |            |
 LIN37 |  E2F5 | 0.983 |            |
 LIN37 |  TESMIN | 0.976 |            |
 LIN9 |  TESMIN | 0.976 |            |
 E2F4 |  E2F5 | 0.974 |            |
 LIN9 |  TFDP2 | 0.972 | 0.226           |
 E2F4 |  LIN37 | 0.969 | 0.146           |
 LIN37 |  TFDP2 | 0.967 | 0.164           |
 LIN37 |  RBL1 | 0.967 | 0.16           |
 RBL2 |  TFDP2 | 0.967 | 0.122           |
 MYBL2 |  MYBL1 | 0.967 |            |
 LIN54 |  TFDP2 | 0.966 | 0.182           |
 RBL1 |  TFDP2 | 0.966 | 0.158           |
 RBL2 |  LIN37 | 0.965 | 0.08           |
 LIN54 |  MYBL2 | 0.965 | 0.206           |
 LIN52 |  TFDP2 | 0.962 | 0.2           |
 RBL1 |  LIN9 | 0.962 | 0.184           |
 E2F2 |  E2F3 | 0.961 |            |
 RBL2 |  LIN9 | 0.96 | 0.122           |
 E2F5 |  E2F2 | 0.959 |            |
 POMC |  E2F4 | 0.95 |            |
 E2F4 |  LIN9 | 0.941 | 0.108           |
 E2F4 |  E2F3 | 0.936 | 0.174           |
 E2F5 |  E2F3 | 0.924 |            |
 E2F4 |  E2F2 | 0.917 |            |
 MCIDAS |  E2F2 | 0.902 |            |
 LIN52 |  E2F2 | 0.902 |            |
 MCIDAS |  E2F3 | 0.902 |            |
 LIN52 |  MCIDAS | 0.892 |            |
 LIN9 |  E2F2 | 0.892 |            |
 MCIDAS |  E2F5 | 0.892 |            |
 LIN54 |  E2F2 | 0.869 |            |
 E2F4 |  MCIDAS | 0.76 |            |
 LIN9 |  MCIDAS | 0.754 |            |
 LIN54 |  MCIDAS | 0.715 |            |
 RBL1 |  E2F2 | 0.703 |            |
 LIN52 |  E2F3 | 0.688 | 0.138           |
 RBL2 |  E2F2 | 0.676 |            |
 E2F4 |  TESMIN | 0.634 |            |
 TESMIN |  TFDP2 | 0.634 |            |
 LIN52 |  TESMIN | 0.633 |            |
 MYBL1 |  TESMIN | 0.633 |            |
 LIN54 |  TESMIN | 0.633 |            |
 LIN54 |  E2F5 | 0.633 |            |
 LIN52 |  E2F5 | 0.633 |            |
 RBL1 |  TESMIN | 0.633 |            |
 RBL2 |  TESMIN | 0.633 |            |
 MYBL2 |  TESMIN | 0.633 |            |
 E2F4 |  MYBL2 | 0.616 | 0.214           |
 E2F4 |  MYBL1 | 0.616 |            |
 MYBL2 |  TFDP2 | 0.616 | 0.218           |
 MYBL1 |  TFDP2 | 0.616 |            |
 RBL2 |  MYBL1 | 0.616 |            |
 RBL2 |  MYBL2 | 0.616 | 0.12           |
 RBL1 |  MYBL1 | 0.616 |            |
 MYBL2 |  RBL1 | 0.616 | 0.238           |
 E2F1 |  E2F3 | 0.582 |            |
 E2F1 |  E2F2 | 0.568 |            |
 E2F5 |  E2F1 | 0.541 |            |
 E2F4 |  RBL1 | 0.526 | 0.154           |
 E2F4 |  RBL2 | 0.524 | 0.09           |
 RBL1 |  E2F3 | 0.468 | 0.138           |
 RBL1 |  MCIDAS | 0.455 |            |
 LIN9 |  E2F5 | 0.428 |            |
 TESMIN |  E2F5 | 0.418 |            |
 RBL2 |  E2F3 | 0.418 | 0.12           |
 RBL2 |  MCIDAS | 0.405 |            |
 LIN52 |  RBL2 | 0.404 | 0.066           |
 E2F4 |  LIN52 | 0.404 | 0.128           |
 LIN52 |  RBL1 | 0.404 | 0.108           |
 RBL2 |  E2F5 | 0.404 |            |
 MYBL1 |  E2F5 | 0.388 |            |
 MYBL2 |  E2F5 | 0.388 |            |
 RBL1 |  E2F5 | 0.384 |            |
 E2F4 |  E2F1 | 0.378 |            |
 LIN54 |  RBL1 | 0.372 | 0.206           |
 RBL2 |  LIN54 | 0.36 | 0.128           |
 LIN9 |  E2F3 | 0.357 | 0.162           |
 E2F4 |  LIN54 | 0.352 | 0.11           |
 LIN54 |  E2F3 | 0.341 | 0.17           |
 MCIDAS |  E2F1 | 0.214 |            |
 LIN52 |  E2F1 | 0.214 |            |
 RBL1 |  E2F1 | 0.146 |            |
 RBL2 |  E2F1 | 0.131 |            |
 LIN9 |  E2F1 | 0.131 |            |
 LIN54 |  E2F1 | 0.108 |            |
 MYBL2 |  E2F3 | 0.022 | 0.138           |
Related Complexes