hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10924.1
Complex Portal: CPX-17785
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AGPS | Alkyldihydroxyacetonephosphate synthase, peroxisomal (Alkyl-DHAP synthase) (EC 2.5.1.26) (Aging-associated gene 5 protein) (Alkylglycerone-phosphate synthase) | 5 | UniProt NCBI |
| NANOS1 | Nanos homolog 1 (NOS-1) (EC_Rep1a) | 5 | UniProt NCBI |
| PEX14 | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | 5 | UniProt NCBI |
| PHYH | Phytanoyl-CoA dioxygenase, peroxisomal (EC 1.14.11.18) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) (PhyH) | 5 | UniProt NCBI |
| C6orf226 | Uncharacterized protein C6orf226 | 2 | UniProt NCBI |
| PEX5 | Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04146 | 2.57899884068e-07 | 0.666666666667 | PHYH PEX5 AGPS PEX14 | Peroxisome |
| HP:0010965 | 1.07472199296e-05 | 0.5 | PEX5 PEX14 PHYH | Abnormal circulating phytanic acid concentration |
| HP:0010571 | 1.07472199296e-05 | 0.5 | PEX5 PEX14 PHYH | Elevated circulating phytanic acid concentration |
| HP:0010964 | 1.65290903262e-05 | 0.5 | PEX5 PEX14 PHYH | Abnormal circulating long-chain fatty-acid concentration |
| REAC:R-HSA-9033241 | 0.00012139707053 | 0.5 | PHYH AGPS PEX14 | Peroxisomal protein import |
| HP:0010655 | 0.000146039911068 | 0.5 | PEX5 AGPS PEX14 | Epiphyseal stippling |
| REAC:R-HSA-9033500 | 0.000387015749065 | 0.333333333333 | AGPS PHYH | TYSND1 cleaves peroxisomal proteins |
| HP:0004359 | 0.000575493098093 | 0.5 | PEX5 PEX14 PHYH | Abnormal circulating fatty-acid concentration |
| HP:0005930 | 0.000696442562876 | 0.666666666667 | PHYH PEX5 AGPS PEX14 | Abnormal epiphysis morphology |
| HP:0010656 | 0.00105494184562 | 0.5 | PEX5 AGPS PEX14 | Abnormal epiphyseal ossification |
| GO:0005777 | 0.00193885768314 | 0.666666666667 | PHYH PEX5 AGPS PEX14 | peroxisome |
| GO:0042579 | 0.00193885768314 | 0.666666666667 | PHYH PEX5 AGPS PEX14 | microbody |
| REAC:R-HSA-9609507 | 0.00283909643482 | 0.5 | PHYH AGPS PEX14 | Protein localization |
| HP:0001088 | 0.00711805296098 | 0.333333333333 | PEX5 PEX14 | Brushfield spots |
| HP:0003336 | 0.00717714082957 | 0.5 | PEX5 AGPS PEX14 | Abnormal enchondral ossification |
| HP:0008064 | 0.00857286967155 | 0.5 | PEX5 PEX14 PHYH | Ichthyosis |
| HP:0008167 | 0.011317974846 | 0.333333333333 | PEX5 PEX14 | Very long chain fatty acid accumulation |
| HP:0002652 | 0.0186233915395 | 0.5 | PEX5 PEX14 PHYH | Skeletal dysplasia |
| GO:0005782 | 0.0188853212627 | 0.5 | PEX5 AGPS PHYH | peroxisomal matrix |
| GO:0031907 | 0.0188853212627 | 0.5 | PEX5 AGPS PHYH | microbody lumen |
| GO:0016560 | 0.0210651876021 | 0.333333333333 | PEX5 PEX14 | protein import into peroxisome matrix, docking |
| HPA:0470682 | 0.0217107992358 | 1.0 | PEX5 PHYH PEX14 C6orf226 NANOS1 AGPS | skin 2; epidermal cells[>=Medium] |
| HP:0000662 | 0.0261590153267 | 0.5 | PEX5 PEX14 PHYH | Nyctalopia |
| GO:0005778 | 0.0289892662643 | 0.5 | PEX5 AGPS PEX14 | peroxisomal membrane |
| GO:0031903 | 0.0289892662643 | 0.5 | PEX5 AGPS PEX14 | microbody membrane |
| HP:0000510 | 0.0313233529835 | 0.5 | PEX5 PEX14 PHYH | Rod-cone dystrophy |
| HP:0011040 | 0.0322780794397 | 0.333333333333 | PEX5 PEX14 | Abnormal intrahepatic bile duct morphology |
| HP:0010766 | 0.0333560250352 | 0.5 | PEX5 AGPS PEX14 | Ectopic calcification |
| HP:0011314 | 0.0401476884444 | 0.666666666667 | PHYH PEX5 AGPS PEX14 | Abnormal long bone morphology |
| GO:0016561 | 0.042122686785 | 0.333333333333 | PEX5 PEX14 | protein import into peroxisome matrix, translocation |
| HP:0005792 | 0.0436511011886 | 0.333333333333 | PEX5 AGPS | Short humerus |
| HP:0006507 | 0.0467604957305 | 0.333333333333 | PEX5 AGPS | Aplasia/hypoplasia of the humerus |
| CORUM:1984 | 0.0499436884912 | 0.166666666667 | PEX14 | PEX14 homodimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PHYH | C6orf226 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| C6orf226 | AGPS | 0.979 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PHYH | PEX5 | 0.967 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PEX14 | PHYH | 0.961 | 0.082 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| NANOS1 | PHYH | 0.953 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PEX14 | PEX5 | 0.871 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| PEX5 | C6orf226 | 0.841 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PEX14 | C6orf226 | 0.269 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PHYH | AGPS | 0.124 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only | |
| PEX5 | AGPS | 0.123 | bioplex3_WMM gupta_WMM WMM_only | ||
| NANOS1 | AGPS | 0.031 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| PEX14 | NANOS1 | 0.022 |
mutually_exclusive (O14832)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PEX14 | AGPS | 0.003 | 0.282 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes