hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10925.1
Complex Portal: CPX-19770
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAP1LC3B2 | Microtubule-associated proteins 1A/1B light chain 3 beta 2 (Microtubule-associated proteins 1A/1B light chain 3B-like) | 4 | UniProt NCBI |
| TBC1D25 | TBC1 domain family member 25 | 5 | UniProt NCBI |
| ATG3 | Ubiquitin-like-conjugating enzyme ATG3 (EC 2.3.2.-) (Autophagy-related protein 3) (APG3-like) (hApg3) (Protein PC3-96) | 5 | UniProt NCBI |
| GABARAPL2 | Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein) | 5 | UniProt NCBI |
| GABARAP | Gamma-aminobutyric acid receptor-associated protein (GABA(A) receptor-associated protein) (MM46) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04140 | 3.00693972585e-06 | 0.8 | ATG3 MAP1LC3B2 GABARAP GABARAPL2 | Autophagy - animal |
| KEGG:04136 | 3.77831543883e-06 | 0.6 | ATG3 GABARAP GABARAPL2 | Autophagy - other |
| REAC:R-HSA-8854214 | 2.84155131715e-05 | 0.6 | TBC1D25 GABARAP GABARAPL2 | TBC/RABGAPs |
| GO:0006995 | 5.37995977657e-05 | 0.6 | GABARAPL2 MAP1LC3B2 GABARAP | cellular response to nitrogen starvation |
| GO:0043562 | 5.37995977657e-05 | 0.6 | GABARAPL2 MAP1LC3B2 GABARAP | cellular response to nitrogen levels |
| GO:0016236 | 0.000109670539315 | 1.0 | TBC1D25 GABARAPL2 MAP1LC3B2 GABARAP ATG3 | macroautophagy |
| KEGG:04137 | 0.000140555997855 | 0.6 | GABARAPL2 MAP1LC3B2 GABARAP | Mitophagy - animal |
| GO:0005776 | 0.000168126820122 | 0.8 | TBC1D25 MAP1LC3B2 GABARAP GABARAPL2 | autophagosome |
| GO:0000422 | 0.000196862025642 | 0.8 | ATG3 MAP1LC3B2 GABARAP GABARAPL2 | autophagy of mitochondrion |
| GO:0000045 | 0.00043484599868 | 0.8 | ATG3 MAP1LC3B2 GABARAP GABARAPL2 | autophagosome assembly |
| KEGG:04621 | 0.000467209213785 | 0.6 | GABARAPL2 MAP1LC3B2 GABARAP | NOD-like receptor signaling pathway |
| GO:1905037 | 0.000513177059613 | 0.8 | ATG3 MAP1LC3B2 GABARAP GABARAPL2 | autophagosome organization |
| WP:WP5412 | 0.000534376000489 | 0.4 | GABARAPL2 GABARAP | 8q11 23 RB1CC1 copy number variation |
| REAC:R-HSA-9007101 | 0.000630278165562 | 0.6 | TBC1D25 GABARAP GABARAPL2 | Rab regulation of trafficking |
| GO:0022411 | 0.000807544779987 | 1.0 | TBC1D25 GABARAPL2 MAP1LC3B2 GABARAP ATG3 | cellular component disassembly |
| REAC:R-HSA-1632852 | 0.00100303062327 | 0.6 | ATG3 GABARAP GABARAPL2 | Macroautophagy |
| GO:0061919 | 0.00130936938487 | 1.0 | TBC1D25 GABARAPL2 MAP1LC3B2 GABARAP ATG3 | process utilizing autophagic mechanism |
| GO:0006914 | 0.00130936938487 | 1.0 | TBC1D25 GABARAPL2 MAP1LC3B2 GABARAP ATG3 | autophagy |
| REAC:R-HSA-9612973 | 0.00140702215103 | 0.6 | ATG3 GABARAP GABARAPL2 | Autophagy |
| GO:1903008 | 0.0022427823715 | 0.8 | ATG3 MAP1LC3B2 GABARAP GABARAPL2 | organelle disassembly |
| GO:0000421 | 0.00522817157061 | 0.6 | GABARAPL2 MAP1LC3B2 GABARAP | autophagosome membrane |
| GO:0007033 | 0.00563530898302 | 0.8 | ATG3 MAP1LC3B2 GABARAP GABARAPL2 | vacuole organization |
| KEGG:04727 | 0.00996128881886 | 0.4 | GABARAPL2 GABARAP | GABAergic synapse |
| KEGG:04068 | 0.028330266578 | 0.4 | GABARAPL2 GABARAP | FoxO signaling pathway |
| WP:WP5224 | 0.0316649111647 | 0.4 | GABARAPL2 GABARAP | 2q37 copy number variation syndrome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ATG3 | GABARAPL2 | 0.999 | 0.072 |
mutually_exclusive (Q9Y4P1)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MAP1LC3B2 | ATG3 | 0.999 | 0.044 |
mutually_exclusive (Q9Y4P1)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ATG3 | GABARAP | 0.997 | 0.212 |
mutually_exclusive (Q9Y4P1)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GABARAP | GABARAPL2 | 0.991 | 0.272 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| TBC1D25 | GABARAPL2 | 0.962 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TBC1D25 | GABARAP | 0.942 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MAP1LC3B2 | GABARAP | 0.907 | 0.212 | bioplex_WMM bioplex3_WMM WMM_only | |
| MAP1LC3B2 | GABARAPL2 | 0.895 | 0.19 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes