hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10927.1

Complex Portal: CPX-23131

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
CDH8	Cadherin-8	5	UniProt NCBI
ARVCF	Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome)	5	UniProt NCBI
CTNNA3	Catenin alpha-3 (Alpha T-catenin) (Cadherin-associated protein)	5	UniProt NCBI
CDH3	Cadherin-3 (Placental cadherin) (P-cadherin)	5	UniProt NCBI
APC	Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)	5	UniProt NCBI
CTNNA2	Catenin alpha-2 (Alpha N-catenin) (Alpha-catenin-related protein)	5	UniProt NCBI
ZFP82	Zinc finger protein 82 homolog (Zfp-82) (Zinc finger protein 545)	3	UniProt NCBI
CDH1	Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]	5	UniProt NCBI
CTNNBIP1	Beta-catenin-interacting protein 1 (Inhibitor of beta-catenin and Tcf-4)	5	UniProt NCBI
CDH10	Cadherin-10 (T2-cadherin)	5	UniProt NCBI
CTNNA1	Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13)	5	UniProt NCBI
CDH4	Cadherin-4 (Retinal cadherin) (R-CAD) (R-cadherin)	5	UniProt NCBI
CDH12	Cadherin-12 (Brain cadherin) (BR-cadherin) (Neural type cadherin 2) (N-cadherin 2)	5	UniProt NCBI
CDH2	Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325)	5	UniProt NCBI
CTNND1	Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))	5	UniProt NCBI
CDH24	Cadherin-24	5	UniProt NCBI
CTNNB1	Catenin beta-1 (Beta-catenin)	5	UniProt NCBI
CDH11	Cadherin-11 (OSF-4) (Osteoblast cadherin) (OB-cadherin)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0016342	5.67281702396e-25	0.733333333333	CTNNA1 CDH24 CTNNA2 CDH12 CTNNB1 CDH11 CDH3 CDH10 CTNND1 CDH4 CDH8	catenin complex
REAC:R-HSA-418990	9.60557560361e-23	0.666666666667	CTNNA1 CDH24 CDH11 CDH12 CTNNB1 CDH3 CDH10 CTNND1 CDH4 CDH8	Adherens junctions interactions
GO:0005912	7.51312863191e-21	0.866666666667	CTNNA1 CDH24 CTNNA2 CDH12 ARVCF CDH11 CDH3 CDH10 CTNNA3 CTNND1 CDH4 CTNNB1 CDH8	adherens junction
REAC:R-HSA-421270	2.32274248425e-20	0.666666666667	CTNNA1 CDH24 CDH11 CDH12 CTNNB1 CDH3 CDH10 CTNND1 CDH4 CDH8	Cell-cell junction organization
REAC:R-HSA-446728	3.87133538111e-18	0.666666666667	CTNNA1 CDH24 CDH11 CDH12 CTNNB1 CDH3 CDH10 CTNND1 CDH4 CDH8	Cell junction organization
GO:0019897	2.21639706168e-17	0.733333333333	CTNNA1 CDH24 CTNNA2 CDH12 CTNNB1 CDH11 CDH3 CDH10 CTNND1 CDH4 CDH8	extrinsic component of plasma membrane
GO:0007043	8.20137659123e-17	0.733333333333	CTNNA1 CDH24 CDH11 CDH12 ARVCF CDH3 CDH10 CTNND1 CDH4 CTNNB1 CDH8	cell-cell junction assembly
REAC:R-HSA-1500931	1.68680750107e-16	0.666666666667	CTNNA1 CDH24 CDH11 CDH12 CTNNB1 CDH3 CDH10 CTNND1 CDH4 CDH8	Cell-Cell communication
GO:0005911	5.34854507119e-16	0.866666666667	CTNNA1 CDH24 CTNNA2 CDH12 ARVCF CDH11 CDH3 CDH10 CTNNA3 CTNND1 CDH4 CTNNB1 CDH8	cell-cell junction
GO:0045296	7.86578771389e-16	0.866666666667	CTNNA1 CDH24 CTNNA2 CDH12 ARVCF CDH11 CDH3 CDH10 CTNNA3 CTNND1 CDH4 CTNNB1 CDH8	cadherin binding
GO:0045216	1.67701511431e-15	0.733333333333	CTNNA1 CDH24 CDH11 CDH12 ARVCF CDH3 CDH10 CTNND1 CDH4 CTNNB1 CDH8	cell-cell junction organization
GO:0019898	2.99469729656e-15	0.733333333333	CTNNA1 CDH24 CTNNA2 CDH12 CTNNB1 CDH11 CDH3 CDH10 CTNND1 CDH4 CDH8	extrinsic component of membrane
WP:WP4541	8.34805583291e-15	0.6	CTNNA1 CDH24 CDH12 CTNNB1 CDH3 CDH10 CDH11 CDH4 CDH8	Hippo Merlin signaling dysregulation
GO:0050839	1.17968534371e-13	0.866666666667	CTNNA1 CDH24 CTNNA2 CDH12 ARVCF CDH11 CDH3 CDH10 CTNNA3 CTNND1 CDH4 CTNNB1 CDH8	cell adhesion molecule binding
GO:0044331	1.86710824175e-13	0.533333333333	CDH12 CDH24 CDH11 CDH3 CDH10 CDH4 CTNND1 CDH8	cell-cell adhesion mediated by cadherin
GO:0034332	2.38115623603e-13	0.533333333333	CDH12 CTNNB1 CDH3 CDH8 CDH10 CDH11 CDH4 CDH24	adherens junction organization
WP:WP5087	3.475979005e-13	0.733333333333	CTNNA1 CDH24 CTNNA2 CDH12 CTNNB1 CDH3 CDH10 CTNNA3 CDH11 CDH4 CDH8	Pleural mesothelioma
WP:WP4540	4.79184508731e-13	0.533333333333	CDH12 CTNNB1 CDH3 CDH8 CDH10 CDH11 CDH4 CDH24	Hippo signaling regulation pathways
GO:0098609	1.39138351175e-12	0.866666666667	CTNNA1 CDH24 CTNNA2 CDH12 ARVCF CDH11 CDH3 CDH10 CTNNA3 CTNND1 CDH4 CTNNB1 CDH8	cell-cell adhesion
GO:0034329	4.11025548108e-12	0.733333333333	CTNNA1 CDH24 CDH11 CDH12 ARVCF CDH3 CDH10 CTNND1 CDH4 CTNNB1 CDH8	cell junction assembly
GO:0034330	5.39997687648e-12	0.8	CTNNA1 CDH24 CTNNA2 CDH12 ARVCF CDH11 CDH3 CDH10 CTNND1 CDH4 CTNNB1 CDH8	cell junction organization
GO:0070161	5.4561675727e-12	0.866666666667	CTNNA1 CDH24 CTNNA2 CDH12 ARVCF CDH11 CDH3 CDH10 CTNNA3 CTNND1 CDH4 CTNNB1 CDH8	anchoring junction
GO:0016339	4.81062888393e-11	0.466666666667	CDH12 CDH3 CDH8 CDH10 CDH11 CDH4 CDH24	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0098797	4.2225177998e-10	0.733333333333	CTNNA1 CDH24 CTNNA2 CDH12 CTNNB1 CDH11 CDH3 CDH10 CTNND1 CDH4 CDH8	plasma membrane protein complex
GO:0007155	1.00546161276e-09	0.866666666667	CTNNA1 CDH24 CTNNA2 CDH12 ARVCF CDH11 CDH3 CDH10 CTNNA3 CTNND1 CDH4 CTNNB1 CDH8	cell adhesion
GO:0030054	2.0118730381e-08	0.866666666667	CTNNA1 CDH24 CTNNA2 CDH12 ARVCF CDH11 CDH3 CDH10 CTNNA3 CTNND1 CDH4 CTNNB1 CDH8	cell junction
CORUM:6337	1.6973856751e-07	0.2	CTNND1 CDH11 CTNNB1	Amot-cadherin-11-beta-catenin-p120 complex
GO:0098742	6.8153230483e-07	0.466666666667	CDH12 CDH3 CDH8 CDH10 CDH11 CDH4 CDH24	cell-cell adhesion via plasma-membrane adhesion molecules
KEGG:04670	1.02520981552e-06	0.333333333333	CTNND1 CTNNA1 CTNNB1 CTNNA3 CTNNA2	Leukocyte transendothelial migration
KEGG:04520	1.02520981552e-06	0.333333333333	CTNND1 CTNNA1 CTNNB1 CTNNA3 CTNNA2	Adherens junction
REAC:R-HSA-525793	2.25795725377e-06	0.266666666667	CTNNA1 CTNNB1 CTNNA2 CDH4	Myogenesis
GO:0098796	3.2497150192e-06	0.733333333333	CTNNA1 CDH24 CTNNA2 CDH12 CTNNB1 CDH11 CDH3 CDH10 CTNND1 CDH4 CDH8	membrane protein complex
KEGG:05213	1.07710284618e-05	0.266666666667	CTNNA1 CTNNB1 CTNNA3 CTNNA2	Endometrial cancer
GO:0000902	2.05513548517e-05	0.6	CDH12 CDH24 CTNNA2 CTNNB1 CDH3 CDH10 CDH11 CDH4 CDH8	cell morphogenesis
WP:WP4155	3.05361062072e-05	0.266666666667	CTNNA1 CTNNB1 CTNNA3 CTNNA2	Endometrial cancer
KEGG:05412	3.2089637529e-05	0.266666666667	CTNNA1 CTNNB1 CTNNA3 CTNNA2	Arrhythmogenic right ventricular cardiomyopathy
WP:WP2118	3.5140911792e-05	0.266666666667	CTNNA1 CTNNB1 CTNNA3 CTNNA2	Arrhythmogenic right ventricular cardiomyopathy
CORUM:6206	4.77291996201e-05	0.133333333333	CTNNB1 CTNNBIP1	ICAT-AR-beta-catenin complex
CORUM:4096	4.77291996201e-05	0.133333333333	CTNNA1 CTNNB1	CTNNA1-CTNNB1 complex
KEGG:05100	5.03101440462e-05	0.266666666667	CTNNA1 CTNNB1 CTNNA3 CTNNA2	Bacterial invasion of epithelial cells
GO:0008013	0.000169371622093	0.333333333333	CTNNBIP1 CTNNA1 CDH24 CTNNA3 CTNNA2	beta-catenin binding
GO:0005509	0.000294430684239	0.466666666667	CDH12 CDH3 CDH8 CDH10 CDH11 CDH4 CDH24	calcium ion binding
KEGG:05226	0.000444431259365	0.266666666667	CTNNA1 CTNNB1 CTNNA3 CTNNA2	Gastric cancer
REAC:R-HSA-5218920	0.000523238235883	0.2	CTNNA1 CTNNB1 CTNND1	VEGFR2 mediated vascular permeability
KEGG:04390	0.000682760335621	0.266666666667	CTNNA1 CTNNB1 CTNNA3 CTNNA2	Hippo signaling pathway
REAC:R-HSA-8876493	0.0105536818496	0.133333333333	CTNND1 CTNNB1	InlA-mediated entry of Listeria monocytogenes into host cells
WP:000000	0.0115632200884	0.933333333333	CTNNA1 CDH24 CTNNBIP1 CDH12 ARVCF CDH11 CDH3 CDH10 CTNNA3 CTNND1 CDH4 CTNNB1 CDH8 CTNNA2	WIKIPATHWAYS
HP:0000670	0.0164272868605	0.266666666667	ARVCF CDH11 CDH3 CTNND1	Carious teeth
WP:WP2858	0.0223950419711	0.2	CTNNB1 CDH8 CTNNA2	Ectoderm differentiation
REAC:R-HSA-4420097	0.0263575601139	0.2	CTNNA1 CTNNB1 CTNND1	VEGFA-VEGFR2 Pathway
REAC:R-HSA-194138	0.0342499455876	0.2	CTNNA1 CTNNB1 CTNND1	Signaling by VEGF
GO:0022607	0.0342524565944	0.733333333333	CTNNA1 CDH24 CDH11 CDH12 ARVCF CDH3 CDH10 CTNND1 CDH4 CTNNB1 CDH8	cellular component assembly
CORUM:6336	0.0498224659463	0.0666666666667	CTNNB1	CTNNB1-DNMT1 complex
CORUM:5281	0.0498224659463	0.0666666666667	CTNNB1	Cell-cell junction complex (CDH1-CTNNB1)
CORUM:5262	0.0498224659463	0.0666666666667	CTNNB1	TCF4-CTNNB1 complex
REAC:R-HSA-8876384	0.0498335486393	0.133333333333	CTNND1 CTNNB1	Listeria monocytogenes entry into host cells

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
CTNNB1	CTNNA1	1.0	0.718	structurally_consistent (dimer)
CDH8	ARVCF	0.999
CDH1	CTNNB1	0.999	0.386	structurally_consistent (dimer)
CTNNA2	CTNNB1	0.999		structurally_consistent (dimer)
CTNNBIP1	CTNNB1	0.999	0.094	structurally_consistent (dimer)
CTNNA2	CTNNA1	0.999
CDH8	CTNNA2	0.999
APC	CTNNB1	0.999	0.258
CDH10	CTNNB1	0.999	0.096
CTNNBIP1	CTNNA1	0.999	0.118
ARVCF	CTNNA1	0.998	0.122
CDH8	CTNNB1	0.998
CTNNB1	ARVCF	0.998	0.154
CTNNA3	CDH1	0.998
CDH8	CTNND1	0.998
CDH24	CDH12	0.998
CTNNA3	CTNND1	0.997
CTNNA3	CDH4	0.997
CDH8	CDH11	0.996
CTNNA3	CTNNB1	0.996		structurally_consistent (dimer)
CDH12	ARVCF	0.996
CTNNA3	CDH24	0.996
CDH8	CTNNA1	0.996
CDH1	CTNND1	0.995	0.172	structurally_consistent (dimer)
CDH1	CDH10	0.994
CDH10	CTNND1	0.994	0.086
CDH8	CDH24	0.994
CTNNBIP1	APC	0.993	0.218
CTNNA3	CTNNBIP1	0.993		structurally_consistent (P35222)
ARVCF	CTNND1	0.992	0.084
CTNNA3	CDH10	0.992
CDH3	CTNNA3	0.992		mutually_exclusive (P35222)
CTNNA1	CTNND1	0.992	0.686
CDH10	ARVCF	0.991	0.066
CTNNA3	CDH12	0.991
CTNNA2	CTNNBIP1	0.99		structurally_consistent (P35222)
APC	CTNNA1	0.989	0.23
CDH12	CTNNB1	0.987		structurally_consistent (dimer)
CDH3	CTNNB1	0.985	0.152	mixed_interface
CTNNA3	APC	0.983
ZFP82	CTNNB1	0.983		structurally_consistent (dimer)
CDH1	CTNNA1	0.981	0.52	structurally_consistent (P35222)
CDH8	CDH12	0.98
CDH1	ARVCF	0.98	0.218
CDH2	CTNNB1	0.98	0.366	structurally_consistent (dimer)
CDH12	CTNNA1	0.98
CTNNA3	CDH2	0.979
CDH12	CTNND1	0.976
CDH12	CTNNA2	0.97
CDH10	CTNNA1	0.947	0.094
CDH1	CDH8	0.932
CDH2	CTNND1	0.927	0.108
CTNNA3	ARVCF	0.921
ZFP82	CTNNBIP1	0.905
CTNNB1	CTNND1	0.901	0.606
CDH24	ARVCF	0.9
CDH8	CDH2	0.834
CDH12	CDH2	0.822		mutually_exclusive (P35222)
CDH10	APC	0.821	0.116
CDH3	ARVCF	0.808	0.102
CDH3	CDH8	0.786
CTNNA2	ARVCF	0.782
CDH1	CDH12	0.76		mutually_exclusive (P35222)
CDH3	CDH1	0.759	0.366	mixed_interface
CDH3	CTNNA1	0.75	0.154
CDH24	CTNNB1	0.676
APC	ARVCF	0.661	0.072
CDH1	CTNNBIP1	0.652	0.086	mutually_exclusive (P35222)
CDH3	CTNNBIP1	0.646	0.036	mutually_exclusive (P35222)
CDH2	CTNNA1	0.642	0.192
CDH1	CTNNA2	0.64
CDH24	CTNNA1	0.598
CTNNA2	APC	0.594
CTNNA3	CTNNA1	0.58
CDH3	CTNNA2	0.572
CDH10	CDH24	0.572
CDH4	CDH24	0.572
CDH11	CDH24	0.572
CDH3	CDH12	0.565		mutually_exclusive (P35222)
CDH4	CDH12	0.557
CDH4	CDH10	0.557
CDH10	CDH12	0.557
CDH4	CTNNBIP1	0.502
CDH10	CTNNBIP1	0.502
CDH4	CTNND1	0.39
CDH11	CTNND1	0.39	0.074
CDH24	CTNND1	0.387
CDH2	ARVCF	0.357	0.238
CDH1	CDH2	0.331	0.302	mutually_exclusive (P35222)
CDH3	CDH24	0.307
CDH4	ARVCF	0.303
CDH11	ARVCF	0.303	0.084
ZFP82	CTNNA1	0.277
CDH1	CDH24	0.258
CDH4	CTNNB1	0.252
CDH11	CTNNB1	0.252	0.216641774892	structurally_consistent (dimer)
CTNNBIP1	ARVCF	0.237	0.04
CDH12	APC	0.222
CDH4	CDH2	0.215
CDH10	CDH2	0.215	0.147
CDH11	CDH2	0.215	0.236	mutually_exclusive (P35222)
CDH1	ZFP82	0.199
CDH11	CTNNA2	0.196
CDH24	APC	0.194
CDH3	CDH10	0.188
CDH3	CDH4	0.188
CDH1	APC	0.186	0.256
CDH3	ZFP82	0.179		mutually_exclusive (P35222)
CTNNA2	ZFP82	0.179		structurally_consistent (P35222)
CDH11	CTNNA1	0.177	0.166
CDH3	APC	0.177	0.09
CDH12	CTNNBIP1	0.172		mutually_exclusive (P35222)
CDH24	CTNNBIP1	0.172
CDH4	CDH1	0.164
CDH24	CTNNA2	0.162
CDH24	CDH2	0.151
CDH3	CTNND1	0.148	0.088	structurally_consistent (P12830)
CDH4	APC	0.143
CDH4	CTNNA1	0.132
CTNNA2	CDH2	0.131
ZFP82	APC	0.102
CDH2	APC	0.091	0.226
CTNNA2	CTNND1	0.089
ZFP82	ARVCF	0.078
CDH3	CDH2	0.077	0.154	mutually_exclusive (P35222)
CTNNBIP1	CDH2	0.076	0.126	mutually_exclusive (P35222)
CTNNBIP1	CTNND1	0.068	0.058
ZFP82	CDH2	0.062
CDH1	CDH11	0.042	0.206	mutually_exclusive (P35222)
CDH3	CDH11	0.03	0.094	mutually_exclusive (P35222)
CTNNA3	CTNNA2	0.023		mutually_exclusive (P35222)
APC	CTNND1	0.02	0.084
ZFP82	CTNND1	0.013
CDH10	CTNNA2	0.013
CDH4	CTNNA2	0.013

Related Complexes

Genename	Complexes
CDH8	huMAP3_03661.1 huMAP3_06953.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
ARVCF	huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
CTNNA3	huMAP3_01242.1 huMAP3_08601.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
CDH3	huMAP3_00026.1 huMAP3_01242.1 huMAP3_07751.1 huMAP3_08033.1 huMAP3_10927.1
APC	huMAP3_05114.1 huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
CTNNA2	huMAP3_05114.1 huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_11960.1 huMAP3_12107.1 huMAP3_13361.1
ZFP82	huMAP3_05114.1 huMAP3_06940.1 huMAP3_07339.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_11965.1 huMAP3_12009.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_13514.1 huMAP3_14353.1 huMAP3_14650.1
CDH1	huMAP3_02788.1 huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1
CTNNBIP1	huMAP3_05114.1 huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_11872.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1 huMAP3_15078.1
CDH10	huMAP3_02788.1 huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
CTNNA1	huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
CDH4	huMAP3_01242.1 huMAP3_08601.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
CDH12	huMAP3_04250.1 huMAP3_06953.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
CDH2	huMAP3_05114.1 huMAP3_06940.1 huMAP3_07339.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12009.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1 huMAP3_15017.1
CTNND1	huMAP3_06940.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
CDH24	huMAP3_04250.1 huMAP3_06953.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1
CTNNB1	huMAP3_05114.1 huMAP3_06940.1 huMAP3_07339.1 huMAP3_08033.1 huMAP3_10927.1 huMAP3_11965.1 huMAP3_12009.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_13514.1 huMAP3_14650.1
CDH11	huMAP3_03661.1 huMAP3_06953.1 huMAP3_10927.1 huMAP3_12107.1 huMAP3_13361.1 huMAP3_14650.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10927.1

Complex Portal: CPX-23131