hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10933.1
Complex Portal: CPX-10625
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TLK1 | Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1) | 5 | UniProt NCBI |
| ATF4 | Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (Tax-responsive enhancer element-binding protein 67) (TaxREB67) | 5 | UniProt NCBI |
| CEBPG | CCAAT/enhancer-binding protein gamma (C/EBP gamma) | 5 | UniProt NCBI |
| CEBPA | CCAAT/enhancer-binding protein alpha (C/EBP alpha) | 5 | UniProt NCBI |
| SPATA1 | Spermatogenesis-associated protein 1 (Sperm-specific protein SP-2) | 3 | UniProt NCBI |
| DDIT3 | DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153) | 5 | UniProt NCBI |
| TLK2 | Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2) | 5 | UniProt NCBI |
| CEBPB | CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4211 | 1.86725537867e-10 | 0.666666666667 | CEBPA CEBPB CEBPG DDIT3 | Transcriptional cascade regulating adipogenesis |
| GO:0036488 | 1.92240082153e-06 | 0.5 | CEBPA CEBPB DDIT3 | CHOP-C/EBP complex |
| REAC:R-HSA-9648895 | 2.56826946848e-06 | 0.5 | DDIT3 CEBPG CEBPB | Response of EIF2AK1 (HRI) to heme deficiency |
| WP:WP2895 | 3.65812487457e-06 | 0.5 | CEBPA CEBPG CEBPB | Differentiation of white and brown adipocyte |
| WP:WP4149 | 6.32218169338e-06 | 0.5 | CEBPA CEBPB DDIT3 | White fat cell differentiation |
| REAC:R-HSA-380994 | 1.83108883385e-05 | 0.5 | DDIT3 CEBPG CEBPB | ATF4 activates genes in response to endoplasmic reticulum stress |
| GO:0140467 | 2.31677849716e-05 | 0.666666666667 | CEBPA CEBPB CEBPG DDIT3 | integrated stress response signaling |
| REAC:R-HSA-381042 | 3.16323162923e-05 | 0.5 | DDIT3 CEBPG CEBPB | PERK regulates gene expression |
| WP:WP236 | 0.000538725402882 | 0.5 | CEBPA CEBPB DDIT3 | Adipogenesis |
| REAC:R-HSA-381119 | 0.000665071217307 | 0.5 | DDIT3 CEBPG CEBPB | Unfolded Protein Response (UPR) |
| REAC:R-HSA-9633012 | 0.00112585873244 | 0.5 | DDIT3 CEBPG CEBPB | Response of EIF2AK4 (GCN2) to amino acid deficiency |
| KEGG:05202 | 0.0011832037204 | 0.5 | CEBPA CEBPB DDIT3 | Transcriptional misregulation in cancer |
| WP:WP3599 | 0.00171766688832 | 0.333333333333 | CEBPA CEBPB | Transcription factor regulation in adipogenesis |
| WP:WP2817 | 0.00326040131097 | 0.333333333333 | CEBPA CEBPB | Mammary gland development pathway Pregnancy and lactation Stage 3 of 4 |
| REAC:R-HSA-9711097 | 0.00404176001974 | 0.5 | DDIT3 CEBPG CEBPB | Cellular response to starvation |
| WP:WP4844 | 0.00436073489596 | 0.333333333333 | CEBPA CEBPB | Influence of laminopathies on Wnt signaling |
| GO:1990647 | 0.00702301080125 | 0.333333333333 | CEBPA CEBPB | C/EBP complex |
| WP:WP4879 | 0.0108030732892 | 0.333333333333 | CEBPA CEBPB | Overlap between signal transduction pathways contributing to LMNA laminopathies |
| WP:WP395 | 0.0108030732892 | 0.333333333333 | CEBPA CEBPB | IL 4 signaling pathway |
| GO:0001889 | 0.0148589937997 | 0.5 | CEBPA CEBPG CEBPB | liver development |
| GO:0061008 | 0.0161301339283 | 0.5 | CEBPA CEBPG CEBPB | hepaticobiliary system development |
| WP:WP3651 | 0.0164862310333 | 0.333333333333 | CEBPA TLK1 | Pathways affected in adenoid cystic carcinoma |
| WP:WP1530 | 0.0207183951349 | 0.333333333333 | TLK1 TLK2 | miRNA regulation of DNA damage response |
| WP:WP707 | 0.0207183951349 | 0.333333333333 | TLK1 TLK2 | DNA damage response |
| GO:0090575 | 0.0275845262239 | 0.666666666667 | CEBPA CEBPB CEBPG DDIT3 | RNA polymerase II transcription regulator complex |
| CORUM:746 | 0.0499436884912 | 0.166666666667 | CEBPA | C/EBPalpha-HNF6 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TLK1 | TLK2 | 1.0 | 0.122 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM |
| SPATA1 | TLK2 | 0.991 | bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TLK1 | SPATA1 | 0.991 | bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| DDIT3 | CEBPG | 0.987 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CEBPA | DDIT3 | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CEBPB | DDIT3 | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ATF4 | CEBPG | 0.981 |
mutually_exclusive (P35638)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| TLK2 | DDIT3 | 0.974 |
mutually_exclusive (Q9UKI8)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| TLK1 | DDIT3 | 0.96 |
mutually_exclusive (Q86UE8)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ATF4 | CEBPB | 0.955 |
mutually_exclusive (P53567)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CEBPA | CEBPB | 0.415 | bioplex3_WMM WMM_only | ||
| CEBPA | CEBPG | 0.278 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only | |
| CEBPB | CEBPG | 0.113 |
structurally_consistent (dimer)
|
bioplex3_WMM WMM_only | |
| TLK1 | CEBPA | 0.113 | bioplex3_WMM WMM_only | ||
| TLK2 | CEBPG | 0.102 | bioplex3_WMM WMM_only | ||
| CEBPA | TLK2 | 0.093 | bioplex3_WMM WMM_only | ||
| TLK1 | CEBPB | 0.078 | bioplex3_WMM WMM_only | ||
| TLK2 | CEBPB | 0.078 | bioplex3_WMM WMM_only | ||
| TLK1 | CEBPG | 0.076 | bioplex3_WMM WMM_only |
Related Complexes