hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10941.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SH2B2 | SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS) | 5 | UniProt NCBI |
| PRPSAP2 | Phosphoribosyl pyrophosphate synthase-associated protein 2 (PRPP synthase-associated protein 2) (41 kDa phosphoribosypyrophosphate synthetase-associated protein) (PAP41) | 5 | UniProt NCBI |
| ACSS2 | Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acetyl-CoA synthetase 1) (AceCS1) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme) (Propionate--CoA ligase) (EC 6.2.1.17) | 5 | UniProt NCBI |
| ELF2 | ETS-related transcription factor Elf-2 (E74-like factor 2) (New ETS-related factor) | 5 | UniProt NCBI |
| PRPSAP1 | Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39) | 5 | UniProt NCBI |
| PRPS1 | Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I) | 5 | UniProt NCBI |
| IVNS1ABP | Influenza virus NS1A-binding protein (NS1-BP) (NS1-binding protein) (Aryl hydrocarbon receptor-associated protein 3) (Kelch-like protein 39) | 5 | UniProt NCBI |
| PRPS2 | Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase II) (PRS-II) | 5 | UniProt NCBI |
| LIPE | Hormone-sensitive lipase (HSL) (EC 3.1.1.79) (Monoacylglycerol lipase LIPE) (EC 3.1.1.23) (Retinyl ester hydrolase) (REH) | 5 | UniProt NCBI |
| TJP3 | Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3) | 5 | UniProt NCBI |
| IRF6 | Interferon regulatory factor 6 (IRF-6) | 5 | UniProt NCBI |
| PRPS1L1 | Ribose-phosphate pyrophosphokinase 3 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 1-like 1) (PRPS1-like 1) (Phosphoribosyl pyrophosphate synthase III) (PRS-III) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0004749 | 0.000115261178119 | 0.3 | PRPSAP1 PRPSAP2 PRPS1 | ribose phosphate diphosphokinase activity |
| GO:0002189 | 0.000115261178119 | 0.3 | PRPSAP1 PRPSAP2 PRPS1 | ribose phosphate diphosphokinase complex |
| GO:0006015 | 0.000115261178119 | 0.3 | PRPSAP1 PRPSAP2 PRPS1 | 5-phosphoribose 1-diphosphate biosynthetic process |
| GO:0046391 | 0.000115261178119 | 0.3 | PRPSAP1 PRPSAP2 PRPS1 | 5-phosphoribose 1-diphosphate metabolic process |
| GO:0016778 | 0.0002304395259 | 0.3 | PRPSAP1 PRPSAP2 PRPS1 | diphosphotransferase activity |
| WP:WP3965 | 0.0133616217617 | 0.2 | LIPE ACSS2 | Lipid metabolism pathway |
| WP:WP143 | 0.0190825311458 | 0.2 | LIPE ACSS2 | Fatty acid beta oxidation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| PRPS2 | PRPSAP2 | 1.0 | 0.262 |
| PRPSAP2 | PRPS1 | 1.0 | 0.192 |
| PRPS1 | PRPSAP1 | 1.0 | 0.13 |
| PRPSAP2 | PRPS1L1 | 1.0 | |
| PRPS2 | PRPSAP1 | 1.0 | 0.302 |
| PRPSAP2 | PRPSAP1 | 1.0 | 0.264 |
| PRPS2 | PRPS1 | 0.999 | 0.454 |
| PRPS1 | PRPS1L1 | 0.999 | |
| IVNS1ABP | PRPSAP1 | 0.999 | 0.132 |
| PRPS2 | ELF2 | 0.997 | |
| PRPSAP2 | IVNS1ABP | 0.995 | 0.072 |
| PRPS2 | ACSS2 | 0.994 | 0.034 |
| PRPS2 | PRPS1L1 | 0.992 | |
| PRPS1 | IVNS1ABP | 0.987 | 0.076 |
| TJP3 | PRPS2 | 0.983 | 0.032 |
| PRPS2 | IRF6 | 0.982 | 0.120217391304 |
| SH2B2 | PRPS2 | 0.978 | |
| PRPS1 | LIPE | 0.973 | 0.31 |
| PRPS1L1 | PRPSAP1 | 0.95 | |
| SH2B2 | ACSS2 | 0.946 | |
| PRPS2 | IVNS1ABP | 0.918 | 0.128 |
| ACSS2 | IRF6 | 0.902 | 0.126 |
| SH2B2 | IRF6 | 0.902 | |
| PRPS1L1 | ELF2 | 0.832 | |
| ELF2 | PRPSAP1 | 0.814 | |
| SH2B2 | PRPSAP2 | 0.779 | |
| PRPSAP2 | ACSS2 | 0.779 | 0.04 |
| ACSS2 | ELF2 | 0.757 | |
| SH2B2 | ELF2 | 0.757 | |
| PRPSAP2 | ELF2 | 0.721 | |
| ELF2 | IRF6 | 0.715 | |
| PRPSAP2 | IRF6 | 0.703 | 0.032 |
| PRPSAP2 | LIPE | 0.703 | 0.144 |
| SH2B2 | TJP3 | 0.698 | |
| TJP3 | IRF6 | 0.698 | 0.1 |
| TJP3 | ACSS2 | 0.698 | 0.062 |
| TJP3 | ELF2 | 0.675 | |
| PRPS1L1 | IRF6 | 0.674 | |
| SH2B2 | PRPS1L1 | 0.674 | |
| PRPS1L1 | ACSS2 | 0.674 | |
| LIPE | PRPS1L1 | 0.674 | |
| TJP3 | PRPS1L1 | 0.671 | |
| SH2B2 | PRPSAP1 | 0.574 | |
| TJP3 | PRPSAP2 | 0.468 | 0.046 |
| ACSS2 | PRPSAP1 | 0.455 | 0.04 |
| IRF6 | PRPSAP1 | 0.437 | 0.076 |
| LIPE | PRPSAP1 | 0.437 | 0.046 |
| PRPS2 | LIPE | 0.388 | 0.188 |
| TJP3 | PRPSAP1 | 0.375 | 0.038 |
| TJP3 | PRPS1 | 0.37 | 0.048 |
| PRPS1 | ELF2 | 0.347 | |
| PRPS1 | IRF6 | 0.32 | 0.068 |
| SH2B2 | PRPS1 | 0.301 | |
| IVNS1ABP | PRPS1L1 | 0.297 | |
| IVNS1ABP | LIPE | 0.255 | 0.032 |
| PRPS1 | ACSS2 | 0.173 | 0.034 |
| LIPE | ELF2 | 0.013 | |
| IVNS1ABP | ELF2 | 0.011 |
Related Complexes