hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10942.1

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
FBXW4	F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4)	4	UniProt NCBI
RC3H2	Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2)	5	UniProt NCBI
MARCHF9	E3 ubiquitin-protein ligase MARCHF9 (EC 2.3.2.27) (Membrane-associated RING finger protein 9) (Membrane-associated RING-CH protein IX) (MARCH-IX) (RING finger protein 179) (RING-type E3 ubiquitin transferase MARCHF9)	5	UniProt NCBI
PFDN5	Prefoldin subunit 5 (Myc modulator 1) (c-Myc-binding protein Mm-1)	5	UniProt NCBI
PFDN1	Prefoldin subunit 1	4	UniProt NCBI
VBP1	Prefoldin subunit 3 (HIBBJ46) (von Hippel-Lindau-binding protein 1) (VBP-1) (VHL-binding protein 1)	5	UniProt NCBI
MTFR1L	Mitochondrial fission regulator 1-like	4	UniProt NCBI
TYMS	Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)	5	UniProt NCBI
WSB2	WD repeat and SOCS box-containing protein 2 (WSB-2) (CS box-containing WD protein)	3	UniProt NCBI
PFDN2	Prefoldin subunit 2	5	UniProt NCBI
PFDN6	Prefoldin subunit 6 (Protein Ke2)	5	UniProt NCBI
KATNB1	Katanin p80 WD40 repeat-containing subunit B1 (Katanin p80 subunit B1) (p80 katanin)	5	UniProt NCBI
PFDN4	Prefoldin subunit 4 (Protein C-1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:33	7.12988705817e-18	0.461538461538	PFDN6 PFDN4 PFDN2 PFDN5 VBP1 PFDN1	Prefoldin complex
CORUM:112	7.12988705817e-18	0.461538461538	PFDN6 PFDN4 PFDN2 PFDN5 VBP1 PFDN1	Prefoldin complex
WP:WP4918	1.48261670135e-17	0.461538461538	PFDN6 PFDN4 PFDN2 PFDN5 VBP1 PFDN1	Cellular proteostasis
GO:0016272	6.34559948177e-15	0.461538461538	PFDN6 PFDN4 PFDN2 PFDN5 VBP1 PFDN1	prefoldin complex
GO:1905907	2.92565102444e-12	0.461538461538	PFDN6 PFDN4 PFDN2 PFDN5 VBP1 PFDN1	negative regulation of amyloid fibril formation
REAC:R-HSA-389957	1.01760573151e-11	0.461538461538	PFDN6 PFDN4 PFDN2 PFDN5 VBP1 PFDN1	Prefoldin mediated transfer of substrate to CCT/TriC
REAC:R-HSA-389958	3.10885389095e-11	0.461538461538	PFDN6 PFDN4 PFDN2 PFDN5 VBP1 PFDN1	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
GO:1905906	3.16424989393e-11	0.461538461538	PFDN6 PFDN4 PFDN2 PFDN5 VBP1 PFDN1	regulation of amyloid fibril formation
REAC:R-HSA-390466	7.97367135399e-11	0.538461538462	PFDN6 PFDN4 PFDN2 FBXW4 VBP1 PFDN1 PFDN5	Chaperonin-mediated protein folding
REAC:R-HSA-391251	1.41166133156e-10	0.538461538462	PFDN6 PFDN4 PFDN2 FBXW4 VBP1 PFDN1 PFDN5	Protein folding
GO:1990000	1.72892204774e-08	0.461538461538	PFDN6 PFDN4 PFDN2 PFDN5 VBP1 PFDN1	amyloid fibril formation
GO:1902904	8.73276376966e-08	0.538461538462	PFDN6 PFDN4 PFDN1 PFDN2 PFDN5 VBP1 KATNB1	negative regulation of supramolecular fiber organization
GO:0061077	3.44459605516e-07	0.461538461538	PFDN6 PFDN4 PFDN2 PFDN5 VBP1 PFDN1	chaperone-mediated protein folding
GO:0001540	6.17568369304e-07	0.461538461538	PFDN6 PFDN4 PFDN2 PFDN5 VBP1 PFDN1	amyloid-beta binding
GO:0051082	7.27709269797e-06	0.461538461538	PFDN6 PFDN4 PFDN2 PFDN5 VBP1 PFDN1	unfolded protein binding
GO:0033218	3.75806082453e-05	0.538461538462	PFDN6 PFDN4 PFDN1 PFDN2 PFDN5 VBP1 TYMS	amide binding
GO:1902903	5.16901168452e-05	0.538461538462	PFDN6 PFDN4 PFDN1 PFDN2 PFDN5 VBP1 KATNB1	regulation of supramolecular fiber organization
GO:0006457	0.000157558897168	0.461538461538	PFDN6 PFDN4 PFDN2 PFDN5 VBP1 PFDN1	protein folding
GO:0042277	0.00064651033446	0.461538461538	PFDN6 PFDN4 PFDN2 PFDN5 VBP1 PFDN1	peptide binding
GO:0051129	0.00319586001884	0.538461538462	PFDN6 PFDN4 PFDN1 PFDN2 PFDN5 VBP1 KATNB1	negative regulation of cellular component organization
REAC:R-HSA-392499	0.00699660503832	0.615384615385	PFDN6 WSB2 PFDN4 PFDN2 FBXW4 VBP1 PFDN1 PFDN5	Metabolism of proteins
GO:0051248	0.00925348586473	0.538461538462	PFDN6 PFDN4 PFDN1 PFDN2 PFDN5 VBP1 TYMS	negative regulation of protein metabolic process
GO:0097435	0.0138917819104	0.538461538462	PFDN6 PFDN4 PFDN1 PFDN2 PFDN5 VBP1 KATNB1	supramolecular fiber organization
GO:0051604	0.0254423884245	0.461538461538	PFDN6 PFDN4 PFDN2 PFDN5 VBP1 PFDN1	protein maturation

Edges

Protein 1	Protein 2	Score	ProteomeHD
PFDN2	VBP1	1.0	0.924
PFDN1	VBP1	1.0	0.932
PFDN4	VBP1	1.0	0.848
PFDN1	PFDN2	1.0	0.916
PFDN6	PFDN2	1.0	0.954
PFDN6	PFDN4	1.0	0.948
PFDN4	PFDN2	1.0	0.928
PFDN5	PFDN2	1.0	0.93
PFDN5	VBP1	1.0	0.866
PFDN1	PFDN5	1.0	0.936
PFDN6	VBP1	1.0	0.91
PFDN4	PFDN1	1.0	0.92
PFDN6	PFDN1	0.999	0.98
PFDN4	PFDN5	0.999	0.902
PFDN6	PFDN5	0.999	0.914
PFDN4	MARCHF9	0.998
KATNB1	PFDN4	0.998	0.15
PFDN4	RC3H2	0.996	0.182
MTFR1L	PFDN1	0.996	0.054
KATNB1	PFDN1	0.995	0.112
FBXW4	PFDN2	0.99
WSB2	PFDN5	0.989
FBXW4	VBP1	0.984
WSB2	PFDN2	0.984
TYMS	PFDN1	0.983	0.038
MARCHF9	VBP1	0.979
PFDN4	MTFR1L	0.977	0.034
MARCHF9	PFDN1	0.976
WSB2	VBP1	0.973
MTFR1L	PFDN2	0.971	0.056
KATNB1	PFDN2	0.965	0.116
FBXW4	PFDN5	0.957
PFDN1	FBXW4	0.947
WSB2	PFDN1	0.945
PFDN4	FBXW4	0.932
RC3H2	PFDN1	0.909	0.21
RC3H2	PFDN2	0.894	0.258
PFDN4	WSB2	0.891
PFDN6	FBXW4	0.875
PFDN4	TYMS	0.874	0.042
TYMS	FBXW4	0.87
MARCHF9	PFDN5	0.869
RC3H2	MTFR1L	0.834	0.08
PFDN6	WSB2	0.819
PFDN6	MTFR1L	0.797	0.076
MTFR1L	VBP1	0.796	0.032
MTFR1L	PFDN5	0.786	0.074
KATNB1	MTFR1L	0.754	0.056
PFDN6	MARCHF9	0.716
TYMS	MTFR1L	0.685	0.066
RC3H2	MARCHF9	0.675
MARCHF9	PFDN2	0.661
TYMS	PFDN5	0.596	0.054
RC3H2	PFDN5	0.533	0.414
KATNB1	RC3H2	0.529	0.164
PFDN6	TYMS	0.485	0.054
KATNB1	PFDN6	0.477	0.174
KATNB1	VBP1	0.467	0.128
TYMS	PFDN2	0.453	0.056
RC3H2	TYMS	0.448	0.098
KATNB1	PFDN5	0.418	0.096
RC3H2	WSB2	0.378
MTFR1L	WSB2	0.356
PFDN6	RC3H2	0.279	0.208
TYMS	VBP1	0.27	0.062
KATNB1	WSB2	0.22
MARCHF9	MTFR1L	0.218
KATNB1	MARCHF9	0.202
RC3H2	VBP1	0.196	0.462
KATNB1	TYMS	0.179	0.042
KATNB1	FBXW4	0.143
MARCHF9	TYMS	0.139
TYMS	WSB2	0.079
WSB2	FBXW4	0.046
RC3H2	FBXW4	0.046
MTFR1L	FBXW4	0.042

Related Complexes

Genename	Complexes
FBXW4	huMAP3_03993.1 huMAP3_04072.1 huMAP3_06614.1 huMAP3_06819.1 huMAP3_08860.1 huMAP3_09036.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14626.1
RC3H2	huMAP3_01955.1 huMAP3_04521.1 huMAP3_08060.1 huMAP3_09234.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14626.1
MARCHF9	huMAP3_01955.1 huMAP3_08998.1 huMAP3_09234.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14626.1
PFDN5	huMAP3_04072.1 huMAP3_06614.1 huMAP3_06819.1 huMAP3_08860.1 huMAP3_09036.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14626.1
PFDN1	huMAP3_03956.1 huMAP3_04396.1 huMAP3_06212.1 huMAP3_07725.1 huMAP3_08998.1 huMAP3_09191.1 huMAP3_09234.1 huMAP3_10656.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14626.1
VBP1	huMAP3_06614.1 huMAP3_06819.1 huMAP3_08860.1 huMAP3_09036.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14626.1
MTFR1L	huMAP3_02935.1 huMAP3_03956.1 huMAP3_08998.1 huMAP3_09234.1 huMAP3_09720.1 huMAP3_10912.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14626.1
TYMS	huMAP3_02498.1 huMAP3_03956.1 huMAP3_08998.1 huMAP3_09234.1 huMAP3_10942.1 huMAP3_12264.1
WSB2	huMAP3_03772.1 huMAP3_04072.1 huMAP3_04750.1 huMAP3_05894.1 huMAP3_06819.1 huMAP3_08860.1 huMAP3_08919.1 huMAP3_09036.1 huMAP3_09980.1 huMAP3_10139.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_13601.1 huMAP3_14626.1
PFDN2	huMAP3_04072.1 huMAP3_06819.1 huMAP3_09036.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14598.1 huMAP3_14626.1
PFDN6	huMAP3_00807.1 huMAP3_06426.1 huMAP3_06819.1 huMAP3_08487.1 huMAP3_09057.1 huMAP3_09234.1 huMAP3_10942.1 huMAP3_11092.1 huMAP3_14584.1 huMAP3_14626.1
KATNB1	huMAP3_00326.1 huMAP3_04019.1 huMAP3_09234.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_11693.1 huMAP3_13167.1 huMAP3_14626.1
PFDN4	huMAP3_01955.1 huMAP3_08060.1 huMAP3_09234.1 huMAP3_10942.1 huMAP3_11361.1 huMAP3_14584.1 huMAP3_14626.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10942.1