hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10947.1
Complex Portal: CPX-22030
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NUDT8 | Mitochondrial coenzyme A diphosphatase NUDT8 (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 8) (Nudix motif 8) | 5 | UniProt NCBI |
| PMPCA | Mitochondrial-processing peptidase subunit alpha (Alpha-MPP) (Inactive zinc metalloprotease alpha) (P-55) | 5 | UniProt NCBI |
| PMPCB | Mitochondrial-processing peptidase subunit beta (EC 3.4.24.64) (Beta-MPP) (P-52) | 5 | UniProt NCBI |
| MEI1 | Meiosis inhibitor protein 1 (Meiosis defective protein 1) | 5 | UniProt NCBI |
| GCHFR | GTP cyclohydrolase 1 feedback regulatory protein (GFRP) (GTP cyclohydrolase I feedback regulatory protein) (p35) | 5 | UniProt NCBI |
| UNKL | Putative E3 ubiquitin-protein ligase UNKL (EC 2.3.2.-) (RING finger protein unkempt-like) (Zinc finger CCCH domain-containing protein 5-like) | 5 | UniProt NCBI |
| SPINK2 | Serine protease inhibitor Kazal-type 2 (Acrosin-trypsin inhibitor) (Epididymis tissue protein Li 172) (HUSI-II) | 5 | UniProt NCBI |
| PABPN1L | Embryonic polyadenylate-binding protein 2 (Embryonic poly(A)-binding protein 2) (ePABP-2) (ePABP2) (Embryonic poly(A)-binding protein type II) (Poly(A)-binding protein nuclear-like 1) | 3 | UniProt NCBI |
| ODAPH | Odontogenesis associated phosphoprotein | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8949664 | 0.00666866305696 | 0.25 | PMPCA PMPCB | Processing of SMDT1 |
| REAC:R-HSA-8949215 | 0.0128161014463 | 0.25 | PMPCA PMPCB | Mitochondrial calcium ion transport |
| GO:0017087 | 0.0131096201623 | 0.25 | PMPCA PMPCB | mitochondrial processing peptidase complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PMPCA | PMPCB | 1.0 | 0.968 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| NUDT8 | PMPCA | 1.0 | 0.154 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NUDT8 | ODAPH | 0.999 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | ||
| PMPCA | ODAPH | 0.997 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | ||
| PMPCB | ODAPH | 0.997 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | ||
| PMPCB | PABPN1L | 0.989 | 0.154 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PMPCA | MEI1 | 0.987 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SPINK2 | NUDT8 | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SPINK2 | PMPCB | 0.979 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PMPCA | PABPN1L | 0.978 | 0.096 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SPINK2 | PMPCA | 0.97 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GCHFR | SPINK2 | 0.968 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NUDT8 | PMPCB | 0.968 | 0.186 |
structurally_consistent (Q10713)
|
bioplex_WMM bioplex3_WMM WMM_only |
| UNKL | PMPCB | 0.953 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | ||
| PMPCB | MEI1 | 0.951 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| NUDT8 | MEI1 | 0.936 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| NUDT8 | PABPN1L | 0.818 | 0.128 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| UNKL | PMPCA | 0.792 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | ||
| GCHFR | NUDT8 | 0.187 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only | |
| GCHFR | PMPCB | 0.074 | 0.072 | bioplex_WMM bioplex3_WMM WMM_only | |
| GCHFR | PMPCA | 0.031 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes