hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10956.1
Complex Portal: CPX-17694
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CST1 | Cystatin-SN (Cystain-SA-I) (Cystatin-1) (Salivary cystatin-SA-1) | 5 | UniProt NCBI |
| RNF141 | RING finger protein 141 (Zinc finger protein 230) | 5 | UniProt NCBI |
| ABCA8 | ABC-type organic anion transporter ABCA8 (EC 7.6.2.-) (ATP-binding cassette sub-family A member 8) | 5 | UniProt NCBI |
| C10orf53 | UPF0728 protein C10orf53 | 2 | UniProt NCBI |
| PLEKHG6 | Pleckstrin homology domain-containing family G member 6 (PH domain-containing family G member 6) (Myosin-interacting guanine nucleotide exchange factor) (MyoGEF) | 5 | UniProt NCBI |
| CRH | Corticoliberin (Corticotropin-releasing factor) (CRF) (Corticotropin-releasing hormone) | 5 | UniProt NCBI |
| AMY1C | Alpha-amylase 1C (EC 3.2.1.1) | 5 | UniProt NCBI |
| CA6 | Carbonic anhydrase 6 (EC 4.2.1.1) (Carbonate dehydratase VI) (Carbonic anhydrase VI) (CA-VI) (Salivary carbonic anhydrase) (Secreted carbonic anhydrase) | 5 | UniProt NCBI |
| CST5 | Cystatin-D (Cystatin-5) | 5 | UniProt NCBI |
| CRYGN | Gamma-crystallin N (Gamma-N-crystallin) | 3 | UniProt NCBI |
| BPIFA2 | BPI fold-containing family A member 2 (Parotid secretory protein) (PSP) (Short palate, lung and nasal epithelium carcinoma-associated protein 2) | 5 | UniProt NCBI |
| AKNAD1 | Protein AKNAD1 | 3 | UniProt NCBI |
| CST4 | Cystatin-S (Cystatin-4) (Cystatin-SA-III) (Salivary acidic protein 1) | 5 | UniProt NCBI |
| CST2 | Cystatin-SA (Cystatin-2) (Cystatin-S5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04970 | 1.32779804747e-05 | 0.307692307692 | CST1 CST2 CST4 AMY1C | Salivary secretion |
| GO:0001580 | 5.71734151998e-05 | 0.307692307692 | CST1 CST2 CA6 CST4 | detection of chemical stimulus involved in sensory perception of bitter taste |
| GO:0050913 | 5.71734151998e-05 | 0.307692307692 | CST1 CST2 CA6 CST4 | sensory perception of bitter taste |
| GO:0050912 | 7.23839541103e-05 | 0.307692307692 | CST1 CST2 CA6 CST4 | detection of chemical stimulus involved in sensory perception of taste |
| GO:0050909 | 0.00023553955807 | 0.307692307692 | CST1 CST2 CA6 CST4 | sensory perception of taste |
| GO:0050907 | 0.000970130895603 | 0.307692307692 | CST1 CST2 CA6 CST4 | detection of chemical stimulus involved in sensory perception |
| GO:0050906 | 0.00580482931134 | 0.307692307692 | CST1 CST2 CA6 CST4 | detection of stimulus involved in sensory perception |
| TF:M05310_1 | 0.00601998990141 | 0.230769230769 | CST1 CST4 CST2 | Factor: ZNF688; motif: MTCAKAAGACC; match class: 1 |
| GO:0009593 | 0.00673500208089 | 0.307692307692 | CST1 CST2 CA6 CST4 | detection of chemical stimulus |
| GO:0007606 | 0.00954566197101 | 0.307692307692 | CST1 CST2 CA6 CST4 | sensory perception of chemical stimulus |
| GO:0004869 | 0.0481879293545 | 0.230769230769 | CST1 CST4 CST2 | cysteine-type endopeptidase inhibitor activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| CST1 | CST4 | 1.0 |
mutually_exclusive (P06850)
|
|
| CRYGN | CA6 | 0.996 | ||
| CA6 | C10orf53 | 0.993 | ||
| CA6 | AKNAD1 | 0.992 | ||
| CST5 | AKNAD1 | 0.992 | ||
| BPIFA2 | AKNAD1 | 0.992 | ||
| CRH | CST5 | 0.99 | ||
| CRH | BPIFA2 | 0.99 | ||
| C10orf53 | AMY1C | 0.982 | ||
| CST1 | BPIFA2 | 0.979 | ||
| CST2 | C10orf53 | 0.977 | ||
| AMY1C | AKNAD1 | 0.976 | ||
| CST2 | BPIFA2 | 0.975 | ||
| CST2 | AKNAD1 | 0.974 | ||
| ABCA8 | CST2 | 0.974 | ||
| BPIFA2 | AMY1C | 0.974 | ||
| PLEKHG6 | CST1 | 0.97 | ||
| CRYGN | CST2 | 0.967 | ||
| CST2 | AMY1C | 0.966 | ||
| CST1 | CRYGN | 0.963 | ||
| CST1 | RNF141 | 0.963 | ||
| CST1 | AKNAD1 | 0.963 | ||
| CST1 | C10orf53 | 0.963 | ||
| CST4 | AKNAD1 | 0.96 | ||
| PLEKHG6 | BPIFA2 | 0.96 | ||
| C10orf53 | CST4 | 0.959 | ||
| RNF141 | CST4 | 0.958 | ||
| CRYGN | CST4 | 0.957 | ||
| CST5 | AMY1C | 0.955 | ||
| CRH | CST1 | 0.954 |
structurally_consistent (dimer)
|
|
| CST4 | BPIFA2 | 0.952 | ||
| ABCA8 | CST4 | 0.95 | ||
| CRH | CST4 | 0.95 |
structurally_consistent (dimer)
|
|
| CST2 | CST5 | 0.948 | ||
| CST1 | CST5 | 0.944 |
structurally_consistent (P09105)
|
|
| CST2 | CST4 | 0.944 |
mutually_exclusive (P09105)
|
|
| CST5 | BPIFA2 | 0.94 | ||
| CST5 | CST4 | 0.919 |
structurally_consistent (P09105)
|
|
| CST1 | CST2 | 0.918 | ||
| CST1 | AMY1C | 0.915 | ||
| CST4 | AMY1C | 0.897 | ||
| CA6 | AMY1C | 0.892 | ||
| CA6 | BPIFA2 | 0.886 | ||
| PLEKHG6 | CST5 | 0.877 | ||
| CST2 | CA6 | 0.839 | ||
| CST5 | CA6 | 0.833 |
structurally_consistent (P09105)
|
|
| CST1 | CA6 | 0.802 | ||
| CA6 | CST4 | 0.778 | ||
| PLEKHG6 | AMY1C | 0.689 | ||
| PLEKHG6 | CST4 | 0.494 | ||
| ABCA8 | AMY1C | 0.034 |
Related Complexes