hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_10960.1

Complex Portal: CPX-19875

Confidence: Medium High

Genename	Protein Name	Uniprot Annotation Score	Links
INA	Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (NF-66) (Neurofilament-66) (Neurofilament 5)	5	UniProt NCBI
DES	Desmin	5	UniProt NCBI
SYNM	Synemin (Desmuslin)	5	UniProt NCBI
NEFL	Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)	5	UniProt NCBI
NEFM	Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein)	5	UniProt NCBI
KRT7	Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7)	5	UniProt NCBI
SYNC	Syncoilin (Syncoilin intermediate filament 1) (Syncoilin-1)	5	UniProt NCBI
BICDL2	BICD family-like cargo adapter 2 (Bicaudal D-related protein 2) (BICD-related protein 2) (BICDR-2) (Coiled-coil domain-containing protein 64B)	4	UniProt NCBI
VIM	Vimentin	5	UniProt NCBI
IDE	Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)	5	UniProt NCBI
NES	Nestin	5	UniProt NCBI
NEFH	Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0045103	2.64238714844e-17	0.9	NEFL VIM SYNC INA DES KRT7 NEFM SYNM NES	intermediate filament-based process
GO:0045104	3.26846874258e-14	0.8	NEFL VIM INA DES KRT7 NEFM SYNM NES	intermediate filament cytoskeleton organization
GO:0005882	1.6798415771e-13	0.8	NEFL VIM INA DES KRT7 NEFM SYNM NES	intermediate filament
GO:0045111	4.40113533035e-12	0.8	NEFL VIM INA DES KRT7 NEFM SYNM NES	intermediate filament cytoskeleton
GO:0045109	2.12777722143e-09	0.6	NEFL INA DES KRT7 NEFM VIM	intermediate filament organization
GO:0099512	7.69867640783e-08	0.9	NEFL VIM SYNC INA DES KRT7 NEFM SYNM NES	supramolecular fiber
GO:0099081	8.61765833762e-08	0.9	NEFL VIM SYNC INA DES KRT7 NEFM SYNM NES	supramolecular polymer
GO:0005200	4.74036470012e-07	0.6	NEFL VIM INA DES NEFM SYNM	structural constituent of cytoskeleton
GO:0099513	9.14412176003e-07	0.8	NEFL VIM INA DES KRT7 NEFM SYNM NES	polymeric cytoskeletal fiber
GO:0099080	4.36294495548e-06	0.9	NEFL VIM SYNC INA DES KRT7 NEFM SYNM NES	supramolecular complex
GO:0099160	1.15344049292e-05	0.3	INA NEFM NEFL	postsynaptic intermediate filament cytoskeleton
GO:0099571	0.000115261178119	0.3	INA NEFM NEFL	postsynaptic cytoskeleton
GO:0005198	0.000326928891584	0.7	NEFL VIM INA DES KRT7 NEFM SYNM	structural molecule activity
GO:0005883	0.000644767051209	0.3	INA NEFM NEFL	neurofilament
GO:0019215	0.00138065085968	0.3	SYNM NES VIM	intermediate filament binding
GO:0007010	0.00200079553388	0.8	NEFL VIM INA DES KRT7 NEFM SYNM NES	cytoskeleton organization
WP:WP5417	0.00225531384444	0.3	NEFL NES NEFM	Cell lineage map for neuronal differentiation
HPA:0130203	0.00977701203432	0.5	SYNM NES BICDL2 VIM SYNC	colon; endothelial cells[High]
HPA:0091032	0.0157531088489	0.3	INA NES NEFM	cerebellum; processes in molecular layer[>=Medium]
HPA:0091031	0.019002675318	0.3	INA NES NEFM	cerebellum; processes in molecular layer[>=Low]
WP:WP2447	0.0216520902792	0.2	NEFL NEFM	Amyotrophic lateral sclerosis ALS
WP:WP383	0.0243817991122	0.2	DES VIM	Striated muscle contraction pathway
GO:0005856	0.0256282932323	0.8	NEFL VIM INA DES KRT7 NEFM SYNM NES	cytoskeleton
WP:WP4352	0.0316161789531	0.3	NEFL VIM NEFM	Ciliary landscape
GO:0097435	0.0447187351818	0.6	NEFL INA DES KRT7 NEFM VIM	supramolecular fiber organization

Edges

Protein 1	Protein 2	Score	ProteomeHD
NEFM	DES	1.0	0.054
NEFM	NES	1.0	0.116
NEFL	NEFM	0.999	0.236
SYNC	DES	0.999
VIM	DES	0.999	0.238
NEFM	VIM	0.999	0.296
NES	DES	0.998	0.094
INA	NEFM	0.998	0.138
NEFM	SYNC	0.997
SYNC	VIM	0.997
SYNC	BICDL2	0.997
SYNC	SYNM	0.996
NES	VIM	0.994	0.532833333333
NEFH	NEFM	0.994	0.126
INA	DES	0.992	0.05
NEFL	SYNC	0.992
IDE	NES	0.992	0.138
SYNM	DES	0.992	0.066
INA	VIM	0.991	0.325107990434
NEFL	NES	0.99	0.144
NEFL	DES	0.988	0.188
INA	SYNC	0.987
IDE	VIM	0.987	0.194610526316
INA	NES	0.984	0.114
KRT7	VIM	0.964	0.402608695652
NEFL	VIM	0.956	0.286
SYNC	NES	0.892
SYNM	NES	0.89	0.142777777778
INA	NEFL	0.861	0.158
IDE	NEFM	0.861	0.082
IDE	NEFL	0.859	0.088
IDE	DES	0.81	0.078
IDE	INA	0.808	0.05
NEFH	NEFL	0.72	0.21
NEFH	VIM	0.712	0.354832628115
NEFM	SYNM	0.678	0.028
INA	NEFH	0.609	0.108
SYNM	VIM	0.527	0.366
BICDL2	DES	0.401
INA	KRT7	0.38	0.136
NEFH	NES	0.24	0.326
NEFM	KRT7	0.239	0.226
IDE	KRT7	0.232	0.058
BICDL2	VIM	0.173
INA	SYNM	0.167	0.056
KRT7	NES	0.154	0.434
NEFL	SYNM	0.154	0.074
BICDL2	SYNM	0.146
NEFL	KRT7	0.112	0.2
IDE	SYNM	0.046	0.088
NEFM	BICDL2	0.042
INA	BICDL2	0.042
NEFL	BICDL2	0.037
NEFH	DES	0.024	0.094
NEFH	SYNC	0.02
BICDL2	NES	0.013
IDE	SYNC	0.008
IDE	NEFH	0.006	0.106

Related Complexes

Genename	Complexes
INA	huMAP3_00659.1 huMAP3_07026.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1
DES	huMAP3_06939.1 huMAP3_10960.1 huMAP3_11715.1
SYNM	huMAP3_02709.1 huMAP3_04868.1 huMAP3_06939.1 huMAP3_10960.1 huMAP3_11715.1 huMAP3_12191.1 huMAP3_13447.1
NEFL	huMAP3_00659.1 huMAP3_07026.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1
NEFM	huMAP3_00659.1 huMAP3_06794.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1
KRT7	huMAP3_05156.1 huMAP3_07026.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1
SYNC	huMAP3_02709.1 huMAP3_06292.1 huMAP3_06939.1 huMAP3_10960.1 huMAP3_11715.1
BICDL2	huMAP3_02709.1 huMAP3_03177.1 huMAP3_06939.1 huMAP3_09117.1 huMAP3_10960.1 huMAP3_11715.1
VIM	huMAP3_05156.1 huMAP3_07026.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1
IDE	huMAP3_00335.1 huMAP3_05156.1 huMAP3_07026.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1 huMAP3_11831.1
NES	huMAP3_05156.1 huMAP3_07026.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_11715.1
NEFH	huMAP3_00659.1 huMAP3_06794.1 huMAP3_09417.1 huMAP3_10960.1 huMAP3_13014.1 huMAP3_15340.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_10960.1

Complex Portal: CPX-19875