hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10963.1
Complex Portal: CPX-13421
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LAT | Linker for activation of T-cells family member 1 (36 kDa phosphotyrosine adapter protein) (pp36) (p36-38) | 5 | UniProt NCBI |
| ATP9B | Probable phospholipid-transporting ATPase IIB (EC 7.6.2.1) (ATPase class II type 9B) | 5 | UniProt NCBI |
| ZDHHC3 | Palmitoyltransferase ZDHHC3 (EC 2.3.1.225) (Acyltransferase ZDHHC3) (EC 2.3.1.-) (Protein DHHC1) (Zinc finger DHHC domain-containing protein 3) (DHHC-3) | 5 | UniProt NCBI |
| MGAT2 | Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC 2.4.1.143) (Beta-1,2-N-acetylglucosaminyltransferase II) (GlcNAc-T II) (GNT-II) (Mannoside acetylglucosaminyltransferase 2) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II) | 5 | UniProt NCBI |
| TSPAN8 | Tetraspanin-8 (Tspan-8) (Transmembrane 4 superfamily member 3) (Tumor-associated antigen CO-029) | 5 | UniProt NCBI |
| ZDHHC20 | Palmitoyltransferase ZDHHC20 (EC 2.3.1.225) (Acyltransferase ZDHHC20) (EC 2.3.1.-) (DHHC domain-containing cysteine-rich protein 20) (DHHC20) (Zinc finger DHHC domain-containing protein 20) | 5 | UniProt NCBI |
| NSUN5 | 28S rRNA (cytosine-C(5))-methyltransferase (EC 2.1.1.-) (NOL1-related protein) (NOL1R) (NOL1/NOP2/Sun domain family member 5) (Williams-Beuren syndrome chromosomal region 20A protein) | 5 | UniProt NCBI |
| SNX19 | Sorting nexin-19 | 5 | UniProt NCBI |
| SLC30A3 | Probable proton-coupled zinc antiporter SLC30A3 (Solute carrier family 30 member 3) (Zinc transporter 3) (ZnT-3) | 5 | UniProt NCBI |
| SLC25A52 | Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A52 (Mitochondrial NAD(+) transporter SLC25A52) (Mitochondrial carrier triple repeat protein 2) (Solute carrier family 25 member 52) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9694548 | 0.000360527139754 | 0.3 | ZDHHC20 ZDHHC3 MGAT2 | Maturation of spike protein |
| REAC:R-HSA-9694635 | 0.0012820759141 | 0.3 | ZDHHC20 ZDHHC3 MGAT2 | Translation of Structural Proteins |
| REAC:R-HSA-9772573 | 0.00206314708251 | 0.3 | ZDHHC20 ZDHHC3 MGAT2 | Late SARS-CoV-2 Infection Events |
| CORUM:2909 | 0.0499436884912 | 0.1 | LAT | PLC-gamma-2-Syk-LAT-FcR-gamma complex |
| CORUM:2913 | 0.0499436884912 | 0.1 | LAT | PLC-gamma-2-LAT complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ZDHHC20 | TSPAN8 | 0.998 | 0.132 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TSPAN8 | ZDHHC3 | 0.997 | 0.098 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LAT | ZDHHC3 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ZDHHC20 | LAT | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SLC30A3 | TSPAN8 | 0.996 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ATP9B | TSPAN8 | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SNX19 | TSPAN8 | 0.99 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MGAT2 | TSPAN8 | 0.981 | 0.056 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SLC25A52 | TSPAN8 | 0.972 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| NSUN5 | TSPAN8 | 0.966 | 0.054 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SLC30A3 | ATP9B | 0.892 | bioplex3_WMM WMM_only | ||
| ATP9B | ZDHHC3 | 0.715 | 0.082 | bioplex3_WMM WMM_only | |
| SLC30A3 | ZDHHC20 | 0.634 | bioplex3_WMM WMM_only | ||
| SLC30A3 | ZDHHC3 | 0.633 | bioplex3_WMM WMM_only | ||
| MGAT2 | ATP9B | 0.545 | 0.072 | bioplex3_WMM WMM_only | |
| SNX19 | ATP9B | 0.405 | 0.104 | bioplex3_WMM WMM_only | |
| ZDHHC20 | ATP9B | 0.388 | 0.068 | bioplex3_WMM WMM_only | |
| ZDHHC20 | ZDHHC3 | 0.384 | 0.134 | bioplex3_WMM WMM_only | |
| MGAT2 | SLC30A3 | 0.269 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SNX19 | SLC30A3 | 0.22 | bioplex3_WMM WMM_only | ||
| NSUN5 | SLC30A3 | 0.207 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NSUN5 | ATP9B | 0.201 | 0.048 | bioplex3_WMM WMM_only | |
| SNX19 | ZDHHC3 | 0.188 | 0.082 | bioplex3_WMM WMM_only | |
| SNX19 | ZDHHC20 | 0.162 | 0.056 | bioplex3_WMM WMM_only | |
| MGAT2 | ZDHHC20 | 0.095 | 0.014 | bioplex3_WMM WMM_only | |
| MGAT2 | ZDHHC3 | 0.08 | 0.052 | bioplex3_WMM WMM_only | |
| SLC25A52 | ZDHHC20 | 0.076 | bioplex3_WMM WMM_only | ||
| SNX19 | MGAT2 | 0.068 | 0.032 | bioplex3_WMM WMM_only | |
| NSUN5 | ZDHHC20 | 0.059 | 0.068 | bioplex3_WMM WMM_only | |
| SLC25A52 | NSUN5 | 0.051 | bioplex3_WMM WMM_only | ||
| SNX19 | SLC25A52 | 0.046 | bioplex3_WMM WMM_only | ||
| SLC25A52 | ATP9B | 0.046 | bioplex3_WMM WMM_only | ||
| SLC25A52 | SLC30A3 | 0.043 | bioplex3_WMM WMM_only | ||
| SLC25A52 | ZDHHC3 | 0.042 | bioplex3_WMM WMM_only | ||
| MGAT2 | NSUN5 | 0.037 | 0.024 | bioplex_WMM bioplex3_WMM WMM_only | |
| SNX19 | NSUN5 | 0.031 | 0.066 | bioplex3_WMM WMM_only | |
| NSUN5 | ZDHHC3 | 0.029 | 0.074 | bioplex3_WMM WMM_only | |
| SLC25A52 | MGAT2 | 0.026 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes