hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10964.1
Complex Portal: CPX-10732
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PTP4A1 | Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1) | 5 | UniProt NCBI |
| FNTB | Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) | 5 | UniProt NCBI |
| DGKZ | Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase zeta) (DGK-zeta) | 5 | UniProt NCBI |
| NAP1L4 | Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2) | 5 | UniProt NCBI |
| FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) | 5 | UniProt NCBI |
| NAP1L1 | Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (hNRP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:419 | 1.70876175213e-05 | 0.333333333333 | FNTB FNTA | Farnesyltransferase |
| KEGG:00900 | 0.00167329519289 | 0.333333333333 | FNTB FNTA | Terpenoid backbone biosynthesis |
| REAC:R-HSA-9648002 | 0.00594265866298 | 0.333333333333 | FNTB FNTA | RAS processing |
| REAC:R-HSA-2514859 | 0.00650743774508 | 0.333333333333 | FNTB FNTA | Inactivation, recovery and regulation of the phototransduction cascade |
| REAC:R-HSA-2514856 | 0.00650743774508 | 0.333333333333 | FNTB FNTA | The phototransduction cascade |
| GO:0004660 | 0.00702301080125 | 0.333333333333 | FNTB FNTA | protein farnesyltransferase activity |
| GO:0005965 | 0.00702301080125 | 0.333333333333 | FNTB FNTA | protein farnesyltransferase complex |
| WP:WP4879 | 0.0108030732892 | 0.333333333333 | FNTA NAP1L1 | Overlap between signal transduction pathways contributing to LMNA laminopathies |
| GO:0018343 | 0.0210651876021 | 0.333333333333 | FNTB FNTA | protein farnesylation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FNTA | FNTB | 1.0 | 0.33 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM |
| NAP1L4 | NAP1L1 | 1.0 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | ||
| FNTB | NAP1L4 | 0.999 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FNTB | NAP1L1 | 0.999 |
mutually_exclusive (P49354)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DGKZ | FNTB | 0.992 | 0.156 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PTP4A1 | FNTA | 0.988 | 0.016 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FNTA | NAP1L1 | 0.987 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM | |
| PTP4A1 | FNTB | 0.983 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DGKZ | NAP1L1 | 0.983 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| FNTA | DGKZ | 0.982 | 0.088 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DGKZ | NAP1L4 | 0.981 | 0.202 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FNTA | NAP1L4 | 0.972 | 0.13 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM WMM_only | |
| PTP4A1 | NAP1L1 | 0.049 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| PTP4A1 | NAP1L4 | 0.032 | 0.214 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes