hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10974.1
Complex Portal: CPX-23927
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SYDE1 | Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) | 5 | UniProt NCBI |
| RHOBTB2 | Rho-related BTB domain-containing protein 2 (Deleted in breast cancer 2 gene protein) (p83) | 5 | UniProt NCBI |
| APLP2 | Amyloid beta precursor like protein 2 (APPH) (Amyloid beta (A4) precursor-like protein 2) (Amyloid protein homolog) (Amyloid-like protein 2) (APLP-2) (CDEI box-binding protein) (CDEBP) (Sperm membrane protein YWK-II) | 5 | UniProt NCBI |
| TAS1R2 | Taste receptor type 1 member 2 (G-protein coupled receptor 71) (Sweet taste receptor T1R2) | 5 | UniProt NCBI |
| APP | Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31] | 5 | UniProt NCBI |
| APBB1 | Amyloid beta precursor protein binding family B member 1 (Amyloid-beta A4 precursor protein-binding family B member 1) (Protein Fe65) | 5 | UniProt NCBI |
| APBB3 | Amyloid-beta A4 precursor protein-binding family B member 3 (Protein Fe65-like 2) (Fe65L2) | 5 | UniProt NCBI |
| APLP1 | Amyloid beta precursor like protein 1 (Amyloid beta (A4) precursor-like protein 1) (Amyloid-like protein 1) (APLP) (APLP-1) [Cleaved into: C30] | 5 | UniProt NCBI |
| QTRT1 | Queuine tRNA-ribosyltransferase catalytic subunit 1 (EC 2.4.2.64) (Guanine insertion enzyme) (tRNA-guanine transglycosylase) | 5 | UniProt NCBI |
| SYDE2 | Rho GTPase-activating protein SYDE2 (Synapse defective protein 1 homolog 2) (Protein syd-1 homolog 2) | 4 | UniProt NCBI |
| APBB2 | Amyloid beta precursor protein binding family B member 2 (Amyloid-beta (A4) precursor protein-binding family B member 2) (Protein Fe65-like 1) | 5 | UniProt NCBI |
| CES2 | Cocaine esterase (EC 3.1.1.84) (Carboxylesterase 2) (CE-2) (hCE-2) (EC 3.1.1.1) (Methylumbelliferyl-acetate deacetylase 2) (EC 3.1.1.56) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:143 | 0.000112726824524 | 0.166666666667 | APP APBB1 | APP-APBB1-LRP1 complex |
| CORUM:7577 | 0.000112726824524 | 0.166666666667 | APP APBB1 | APP-APBB1-KAT5 complex |
| CORUM:2711 | 0.0499436884912 | 0.0833333333333 | APP | Amyloid beta protein homo-oligomer complex |
| CORUM:6056 | 0.0499436884912 | 0.0833333333333 | APP | APP-TNFRSF21 complex |
| CORUM:7529 | 0.0499436884912 | 0.0833333333333 | APP | APP-Abeta42-VDAC1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RHOBTB2 | APBB3 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| APBB2 | APP | 1.0 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| APBB1 | APP | 0.999 | 0.07 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| APBB1 | SYDE1 | 0.999 | 0.134 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| APBB1 | APLP2 | 0.999 | 0.116 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| APBB2 | APLP2 | 0.999 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| APBB3 | APP | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| APBB2 | APLP1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| APBB3 | APLP2 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| APP | CES2 | 0.996 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| APLP1 | APBB3 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| APBB1 | APBB2 | 0.992 | 0.118 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| APBB1 | APLP1 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| APBB2 | SYDE1 | 0.99 | 0.136 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TAS1R2 | QTRT1 | 0.989 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| APBB2 | QTRT1 | 0.987 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| APP | QTRT1 | 0.983 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SYDE2 | APBB2 | 0.963 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SYDE1 | APLP2 | 0.941 | 0.09 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| APLP1 | APLP2 | 0.87 | bioplex_WMM bioplex3_WMM WMM_only | ||
| APP | APLP2 | 0.861 | 0.262 | bioplex_WMM bioplex3_WMM WMM_only | |
| APBB1 | QTRT1 | 0.792 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | |
| RHOBTB2 | APLP2 | 0.665 | bioplex_WMM bioplex3_WMM WMM_only | ||
| APLP1 | SYDE1 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RHOBTB2 | APLP1 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| APP | SYDE1 | 0.476 | 0.064 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| APLP1 | APP | 0.301 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYDE2 | APLP1 | 0.224 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TAS1R2 | APLP2 | 0.224 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| RHOBTB2 | APP | 0.175 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYDE2 | APBB1 | 0.168 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYDE2 | APP | 0.143 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYDE2 | APLP2 | 0.122 | bioplex_WMM bioplex3_WMM WMM_only | ||
| QTRT1 | APLP2 | 0.082 | 0.042 | bioplex3_WMM WMM_only | |
| APP | TAS1R2 | 0.034 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes