hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10975.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| VAV2 | Guanine nucleotide exchange factor VAV2 (VAV-2) | 5 | UniProt NCBI |
| SHC2 | SHC-transforming protein 2 (Protein Sck) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) | 5 | UniProt NCBI |
| ECHDC3 | Enoyl-CoA hydratase domain-containing protein 3, mitochondrial | 4 | UniProt NCBI |
| RGPD3 | RanBP2-like and GRIP domain-containing protein 3 | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04650 | 0.014619629343 | 0.5 | VAV2 SHC2 | Natural killer cell mediated cytotoxicity |
| WP:WP3929 | 0.0183400443465 | 0.5 | VAV2 SHC2 | Chemokine signaling pathway |
| WP:WP2380 | 0.01895043011 | 0.5 | VAV2 SHC2 | Brain derived neurotrophic factor BDNF signaling pathway |
| KEGG:04062 | 0.0237566589162 | 0.5 | VAV2 SHC2 | Chemokine signaling pathway |
| KEGG:04510 | 0.03673756538 | 0.5 | VAV2 SHC2 | Focal adhesion |
| WP:WP306 | 0.0374055211141 | 0.5 | VAV2 SHC2 | Focal adhesion |
| REAC:R-HSA-4420097 | 0.0380580405855 | 0.5 | VAV2 SHC2 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-194138 | 0.0453901932463 | 0.5 | VAV2 SHC2 | Signaling by VEGF |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| VAV2 | SHC2 | 0.973 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SHC2 | ECHDC3 | 0.969 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RGPD3 | SHC2 | 0.959 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| VAV2 | ECHDC3 | 0.146 | 0.036 | bioplex3_WMM WMM_only |
| RGPD3 | VAV2 | 0.1 | bioplex3_WMM WMM_only | |
| RGPD3 | ECHDC3 | 0.075 | bioplex3_WMM WMM_only |
Related Complexes