hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10976.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TMA16 | Translation machinery-associated protein 16 | 5 | UniProt NCBI |
| GIGYF2 | GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein) | 5 | UniProt NCBI |
| G3BP2 | Ras GTPase-activating protein-binding protein 2 (G3BP-2) (GAP SH3 domain-binding protein 2) | 5 | UniProt NCBI |
| LSG1 | Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.1.-) | 5 | UniProt NCBI |
| USP10 | Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10) | 5 | UniProt NCBI |
| NEMF | Ribosome quality control complex subunit NEMF (Antigen NY-CO-1) (Nuclear export mediator factor) (Serologically defined colon cancer antigen 1) | 5 | UniProt NCBI |
| CAPRIN1 | Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105) | 5 | UniProt NCBI |
| G3BP1 | Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1) | 5 | UniProt NCBI |
| AVEN | Cell death regulator Aven | 4 | UniProt NCBI |
| KIAA0408 | Uncharacterized protein KIAA0408 | 5 | UniProt NCBI |
| PRRC2A | Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2) | 5 | UniProt NCBI |
| EIF5B | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0062028 | 6.50952358374e-08 | 0.333333333333 | USP10 G3BP1 G3BP2 CAPRIN1 | regulation of stress granule assembly |
| GO:0062029 | 8.45465618902e-05 | 0.25 | CAPRIN1 G3BP2 G3BP1 | positive regulation of stress granule assembly |
| GO:0034063 | 0.000192851461451 | 0.333333333333 | USP10 G3BP1 G3BP2 CAPRIN1 | stress granule assembly |
| GO:0010494 | 0.0170704961012 | 0.333333333333 | CAPRIN1 G3BP1 GIGYF2 G3BP2 | cytoplasmic stress granule |
| HPA:0630222 | 0.0285894374554 | 0.75 | EIF5B GIGYF2 LSG1 CAPRIN1 G3BP1 NEMF USP10 AVEN G3BP2 | cervix; squamous epithelial cells[>=Medium] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| G3BP1 | USP10 | 1.0 | 0.662 |
| G3BP2 | USP10 | 1.0 | 0.144 |
| CAPRIN1 | G3BP2 | 1.0 | 0.212 |
| G3BP1 | G3BP2 | 0.999 | 0.373666666667 |
| AVEN | USP10 | 0.995 | 0.114 |
| AVEN | EIF5B | 0.993 | 0.116 |
| AVEN | NEMF | 0.991 | 0.082 |
| G3BP2 | TMA16 | 0.99 | 0.146 |
| CAPRIN1 | USP10 | 0.989 | 0.48 |
| CAPRIN1 | G3BP1 | 0.988 | 0.84 |
| EIF5B | G3BP1 | 0.986 | 0.718 |
| EIF5B | LSG1 | 0.983 | 0.142 |
| PRRC2A | EIF5B | 0.981 | 0.236 |
| NEMF | G3BP1 | 0.98 | 0.156 |
| NEMF | USP10 | 0.98 | 0.118 |
| KIAA0408 | AVEN | 0.979 | |
| AVEN | G3BP2 | 0.978 | 0.132 |
| GIGYF2 | PRRC2A | 0.974 | 0.14 |
| AVEN | G3BP1 | 0.973 | 0.076 |
| G3BP2 | LSG1 | 0.97 | 0.2 |
| AVEN | CAPRIN1 | 0.97 | 0.118 |
| PRRC2A | G3BP1 | 0.967 | 0.216 |
| NEMF | EIF5B | 0.967 | 0.162 |
| GIGYF2 | G3BP1 | 0.966 | 0.512 |
| TMA16 | LSG1 | 0.965 | 0.104 |
| AVEN | LSG1 | 0.964 | 0.048 |
| NEMF | G3BP2 | 0.964 | 0.108 |
| G3BP1 | TMA16 | 0.962 | 0.112 |
| G3BP1 | LSG1 | 0.96 | 0.244 |
| USP10 | TMA16 | 0.959 | 0.098 |
| USP10 | LSG1 | 0.955 | 0.096 |
| NEMF | LSG1 | 0.925 | 0.07 |
| NEMF | TMA16 | 0.901 | 0.074 |
| AVEN | TMA16 | 0.889 | 0.042 |
| EIF5B | USP10 | 0.886 | 0.536 |
| GIGYF2 | EIF5B | 0.815 | 0.376 |
| PRRC2A | USP10 | 0.722 | 0.266 |
| GIGYF2 | AVEN | 0.663 | 0.188 |
| PRRC2A | CAPRIN1 | 0.586 | 0.284 |
| NEMF | CAPRIN1 | 0.579 | 0.098 |
| PRRC2A | TMA16 | 0.523 | 0.06 |
| GIGYF2 | NEMF | 0.515 | 0.234 |
| PRRC2A | LSG1 | 0.406 | 0.048 |
| PRRC2A | NEMF | 0.331 | 0.178 |
| GIGYF2 | TMA16 | 0.216 | 0.06 |
| GIGYF2 | G3BP2 | 0.196 | 0.254 |
| KIAA0408 | G3BP1 | 0.171 | |
| GIGYF2 | LSG1 | 0.151 | 0.102 |
| PRRC2A | AVEN | 0.15 | 0.11 |
| PRRC2A | KIAA0408 | 0.137 | |
| KIAA0408 | USP10 | 0.103 | |
| GIGYF2 | USP10 | 0.103 | 0.586 |
| EIF5B | TMA16 | 0.095 | 0.198 |
| EIF5B | G3BP2 | 0.08 | 0.263 |
| KIAA0408 | G3BP2 | 0.068 | |
| CAPRIN1 | LSG1 | 0.059 | 0.126 |
| PRRC2A | G3BP2 | 0.054 | 0.185818181818 |
| GIGYF2 | CAPRIN1 | 0.053 | 0.462 |
| KIAA0408 | NEMF | 0.051 | |
| EIF5B | CAPRIN1 | 0.04 | 0.43 |
| CAPRIN1 | TMA16 | 0.039 | 0.09 |
| KIAA0408 | CAPRIN1 | 0.038 | |
| KIAA0408 | EIF5B | 0.031 | |
| GIGYF2 | KIAA0408 | 0.018 |
Related Complexes