hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10979.1
Complex Portal: CPX-20699
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PCDHB9 | Protocadherin beta-9 (PCDH-beta-9) (Protocadherin-3H) | 4 | UniProt NCBI |
| MST1R | Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain] | 5 | UniProt NCBI |
| PCDHB6 | Protocadherin beta-6 (PCDH-beta-6) | 5 | UniProt NCBI |
| PCDHB13 | Protocadherin beta-13 (PCDH-beta-13) | 4 | UniProt NCBI |
| PCDHB12 | Protocadherin beta-12 (PCDH-beta-12) | 5 | UniProt NCBI |
| PCDHB11 | Protocadherin beta-11 (PCDH-beta-11) | 5 | UniProt NCBI |
| TMTC2 | Protein O-mannosyl-transferase TMTC2 (EC 2.4.1.109) (Transmembrane O-mannosyltransferase targeting cadherins 2) (Transmembrane and tetratricopeptide repeat-containing 2) | 5 | UniProt NCBI |
| PCDHB10 | Protocadherin beta-10 (PCDH-beta-10) | 4 | UniProt NCBI |
| PCDHB8 | Protocadherin beta-8 (PCDH-beta-8) (Protocadherin-3I) | 4 | UniProt NCBI |
| PCDHB16 | Protocadherin beta-16 (PCDH-beta-16) (Protocadherin-3X) | 5 | UniProt NCBI |
| PCDHB7 | Protocadherin beta-7 (PCDH-beta-7) | 4 | UniProt NCBI |
| PCDHB3 | Protocadherin beta-3 (PCDH-beta-3) | 4 | UniProt NCBI |
| PCDHB5 | Protocadherin beta-5 (PCDH-beta-5) | 4 | UniProt NCBI |
| C2CD2L | Phospholipid transfer protein C2CD2L (C2 domain-containing protein 2-like) (C2CD2-like) (Transmembrane protein 24) | 5 | UniProt NCBI |
| PCDHB4 | Protocadherin beta-4 (PCDH-beta-4) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0016339 | 1.14387314836e-16 | 0.6 | PCDHB3 PCDHB5 PCDHB4 PCDHB9 PCDHB13 PCDHB11 PCDHB10 PCDHB6 PCDHB16 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules |
| GO:0007416 | 3.75662512481e-12 | 0.6 | PCDHB3 PCDHB5 PCDHB4 PCDHB9 PCDHB13 PCDHB11 PCDHB10 PCDHB6 PCDHB16 | synapse assembly |
| GO:0098742 | 3.24287470355e-11 | 0.6 | PCDHB3 PCDHB5 PCDHB4 PCDHB9 PCDHB13 PCDHB11 PCDHB10 PCDHB6 PCDHB16 | cell-cell adhesion via plasma-membrane adhesion molecules |
| GO:0050808 | 8.12564836175e-09 | 0.6 | PCDHB3 PCDHB5 PCDHB4 PCDHB9 PCDHB13 PCDHB11 PCDHB10 PCDHB6 PCDHB16 | synapse organization |
| GO:0034329 | 4.66221738831e-08 | 0.6 | PCDHB3 PCDHB5 PCDHB4 PCDHB9 PCDHB13 PCDHB11 PCDHB10 PCDHB6 PCDHB16 | cell junction assembly |
| GO:0007155 | 6.63244347682e-08 | 0.8 | PCDHB7 PCDHB3 PCDHB5 PCDHB4 PCDHB9 PCDHB16 PCDHB13 PCDHB11 PCDHB6 PCDHB8 PCDHB10 PCDHB12 | cell adhesion |
| GO:0007268 | 5.56892233082e-07 | 0.6 | PCDHB3 PCDHB5 PCDHB4 PCDHB9 PCDHB13 PCDHB11 PCDHB10 PCDHB6 PCDHB16 | chemical synaptic transmission |
| GO:0098916 | 5.56892233082e-07 | 0.6 | PCDHB3 PCDHB5 PCDHB4 PCDHB9 PCDHB13 PCDHB11 PCDHB10 PCDHB6 PCDHB16 | anterograde trans-synaptic signaling |
| GO:0099537 | 6.16114558863e-07 | 0.6 | PCDHB3 PCDHB5 PCDHB4 PCDHB9 PCDHB13 PCDHB11 PCDHB10 PCDHB6 PCDHB16 | trans-synaptic signaling |
| GO:0099536 | 1.02825412515e-06 | 0.6 | PCDHB3 PCDHB5 PCDHB4 PCDHB9 PCDHB13 PCDHB11 PCDHB10 PCDHB6 PCDHB16 | synaptic signaling |
| GO:0034330 | 2.52757095645e-06 | 0.6 | PCDHB3 PCDHB5 PCDHB4 PCDHB9 PCDHB13 PCDHB11 PCDHB10 PCDHB6 PCDHB16 | cell junction organization |
| GO:0098609 | 3.04497850104e-05 | 0.6 | PCDHB3 PCDHB5 PCDHB4 PCDHB9 PCDHB13 PCDHB11 PCDHB10 PCDHB6 PCDHB16 | cell-cell adhesion |
| GO:0007267 | 0.000125142761929 | 0.666666666667 | C2CD2L PCDHB3 PCDHB5 PCDHB4 PCDHB9 PCDHB13 PCDHB11 PCDHB10 PCDHB6 PCDHB16 | cell-cell signaling |
| GO:0007399 | 0.000150937749373 | 0.733333333333 | PCDHB3 PCDHB5 MST1R PCDHB9 PCDHB16 PCDHB12 PCDHB11 PCDHB4 PCDHB10 PCDHB6 PCDHB13 | nervous system development |
| TF:M01284_1 | 0.000922241774923 | 0.6 | PCDHB5 MST1R PCDHB8 PCDHB16 PCDHB9 PCDHB11 PCDHB3 PCDHB10 PCDHB13 | Factor: Sox-9; motif: RNACAAAGGVN; match class: 1 |
| TF:M10067_1 | 0.00206455515491 | 0.6 | PCDHB5 MST1R PCDHB8 PCDHB16 PCDHB9 PCDHB11 PCDHB3 PCDHB10 PCDHB13 | Factor: Sox-2; motif: NNCCTTTGTNYYN; match class: 1 |
| TF:M07230_1 | 0.00873637568369 | 0.4 | PCDHB8 PCDHB16 PCDHB11 PCDHB5 PCDHB12 PCDHB13 | Factor: TAL1::GATA1; motif: NTTATCWNNNNNNNNCAG; match class: 1 |
| GO:0048731 | 0.0164546996009 | 0.733333333333 | PCDHB3 PCDHB5 MST1R PCDHB9 PCDHB16 PCDHB12 PCDHB11 PCDHB4 PCDHB10 PCDHB6 PCDHB13 | system development |
| TF:M10069_1 | 0.0256037237701 | 0.6 | PCDHB5 PCDHB8 PCDHB16 PCDHB9 PCDHB11 PCDHB3 PCDHB10 PCDHB13 PCDHB12 | Factor: Sox-4; motif: NYCTTTGTYYYN; match class: 1 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| PCDHB3 | PCDHB7 | 1.0 |
mutually_exclusive (Q9NRJ7)
structurally_consistent (dimer) |
|
| PCDHB8 | PCDHB3 | 1.0 |
structurally_consistent (dimer)
|
|
| PCDHB3 | PCDHB10 | 1.0 |
mutually_exclusive (Q9NRJ7)
structurally_consistent (dimer) |
|
| PCDHB5 | PCDHB3 | 1.0 |
structurally_consistent (dimer)
|
|
| PCDHB4 | PCDHB3 | 1.0 |
structurally_consistent (dimer)
|
|
| PCDHB16 | PCDHB3 | 0.999 |
structurally_consistent (dimer)
|
|
| PCDHB13 | PCDHB3 | 0.999 |
structurally_consistent (dimer)
|
|
| PCDHB9 | PCDHB3 | 0.999 |
structurally_consistent (dimer)
|
|
| PCDHB16 | PCDHB7 | 0.998 |
mutually_exclusive (Q9Y5E6)
structurally_consistent (dimer) |
|
| C2CD2L | PCDHB3 | 0.996 | ||
| TMTC2 | PCDHB3 | 0.996 | ||
| PCDHB13 | PCDHB11 | 0.994 |
structurally_consistent (dimer)
|
|
| PCDHB16 | C2CD2L | 0.994 | ||
| PCDHB6 | PCDHB12 | 0.993 |
structurally_consistent (dimer)
|
|
| PCDHB6 | PCDHB4 | 0.992 |
structurally_consistent (dimer)
|
|
| PCDHB11 | PCDHB12 | 0.992 |
structurally_consistent (dimer)
|
|
| PCDHB6 | PCDHB16 | 0.989 |
structurally_consistent (dimer)
|
|
| PCDHB7 | PCDHB12 | 0.988 |
structurally_consistent (dimer)
|
|
| TMTC2 | PCDHB7 | 0.98 | ||
| C2CD2L | PCDHB7 | 0.979 | ||
| MST1R | PCDHB7 | 0.961 | ||
| PCDHB5 | PCDHB11 | 0.959 |
structurally_consistent (dimer)
|
|
| PCDHB4 | PCDHB10 | 0.949 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB8 | PCDHB10 | 0.949 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB9 | PCDHB10 | 0.949 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB5 | PCDHB10 | 0.949 |
mutually_exclusive (Q9Y5E6)
|
|
| TMTC2 | PCDHB11 | 0.949 | ||
| PCDHB4 | PCDHB5 | 0.946 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB5 | PCDHB9 | 0.946 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB5 | PCDHB8 | 0.946 | 0.138 |
mutually_exclusive (Q9Y5E6)
|
| PCDHB4 | PCDHB8 | 0.946 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB4 | PCDHB9 | 0.946 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB9 | PCDHB8 | 0.946 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB13 | PCDHB8 | 0.946 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB16 | PCDHB8 | 0.946 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB8 | PCDHB7 | 0.946 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB4 | PCDHB7 | 0.946 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB13 | PCDHB7 | 0.946 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB9 | PCDHB7 | 0.946 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB13 | PCDHB10 | 0.946 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB13 | PCDHB9 | 0.946 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB4 | PCDHB13 | 0.946 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB16 | PCDHB9 | 0.946 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB16 | PCDHB10 | 0.944 |
mutually_exclusive (Q9Y5E6)
structurally_consistent (dimer) |
|
| PCDHB4 | PCDHB16 | 0.933 | ||
| PCDHB5 | PCDHB7 | 0.931 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB13 | PCDHB5 | 0.931 | ||
| PCDHB16 | PCDHB13 | 0.923 |
mutually_exclusive (Q9Y5E6)
|
|
| PCDHB10 | PCDHB7 | 0.916 | ||
| TMTC2 | PCDHB8 | 0.904 | 0.068 | |
| TMTC2 | PCDHB9 | 0.904 | ||
| TMTC2 | PCDHB10 | 0.883 | ||
| PCDHB16 | PCDHB5 | 0.826 |
mutually_exclusive (Q9Y5E6)
|
|
| TMTC2 | PCDHB12 | 0.782 | ||
| PCDHB4 | TMTC2 | 0.768 | ||
| C2CD2L | PCDHB13 | 0.732 | ||
| TMTC2 | PCDHB5 | 0.715 | 0.08 | |
| C2CD2L | PCDHB9 | 0.715 | ||
| C2CD2L | PCDHB8 | 0.715 | 0.102 | |
| PCDHB4 | C2CD2L | 0.675 | ||
| TMTC2 | PCDHB13 | 0.668 | ||
| C2CD2L | PCDHB11 | 0.662 | ||
| C2CD2L | TMTC2 | 0.652 | 0.12 | |
| PCDHB16 | TMTC2 | 0.651 | ||
| C2CD2L | PCDHB5 | 0.631 | 0.05 | |
| PCDHB3 | MST1R | 0.593 | ||
| C2CD2L | PCDHB10 | 0.588 | ||
| PCDHB6 | PCDHB7 | 0.502 | ||
| PCDHB13 | PCDHB12 | 0.502 |
mutually_exclusive (Q9Y5F2)
|
|
| PCDHB4 | PCDHB12 | 0.415 |
mutually_exclusive (Q9Y5E3)
|
|
| TMTC2 | MST1R | 0.301 | 0.044 | |
| C2CD2L | PCDHB12 | 0.234 | ||
| PCDHB6 | C2CD2L | 0.143 | ||
| PCDHB13 | MST1R | 0.107 | ||
| PCDHB8 | MST1R | 0.101 | 0.078 | |
| PCDHB10 | MST1R | 0.101 | ||
| PCDHB9 | MST1R | 0.101 | ||
| PCDHB4 | MST1R | 0.076 | ||
| PCDHB5 | MST1R | 0.074 | ||
| MST1R | PCDHB12 | 0.074 | ||
| C2CD2L | MST1R | 0.067 | 0.112 | |
| PCDHB16 | MST1R | 0.066 | ||
| PCDHB6 | PCDHB10 | 0.024 |
mutually_exclusive (Q9NRJ7)
|
Related Complexes