hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_10986.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SLC39A1 | Zinc transporter ZIP1 (Solute carrier family 39 member 1) (Zinc-iron-regulated transporter-like) (Zrt- and Irt-like protein 1) (ZIP-1) (hZIP1) | 5 | UniProt NCBI |
| TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)] | 5 | UniProt NCBI |
| TNF | Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form] | 5 | UniProt NCBI |
| DOLK | Dolichol kinase (EC 2.7.1.108) (Transmembrane protein 15) | 5 | UniProt NCBI |
| TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6347 | 3.07520988333e-05 | 0.5 | TNF TRADD | TNF-R1 signaling complex |
| WP:WP2513 | 0.000168398502686 | 0.5 | TNF TRADD | Nanoparticle triggered regulated necrosis |
| WP:WP5182 | 0.000232143427839 | 0.5 | TNF TRADD | Pro survival signaling of neuroprotectin D1 |
| CORUM:6344 | 0.000465981333253 | 0.5 | TNF TRADD | TNF-R1-associated signaling complex |
| WP:WP262 | 0.000588856887782 | 0.5 | TNF TRADD | Ebstein Barr virus LMP1 signaling |
| REAC:R-HSA-5357786 | 0.00282403231951 | 0.5 | TNF TRADD | TNFR1-induced proapoptotic signaling |
| WP:WP5039 | 0.00337093843289 | 0.5 | TNF TRADD | SARS CoV 2 innate immunity evasion and cell specific immune response |
| WP:WP3865 | 0.00363720277712 | 0.5 | TNF TRADD | Novel intracellular components of RIG I like receptor pathway |
| KEGG:04920 | 0.00487132756685 | 0.5 | TNF TRADD | Adipocytokine signaling pathway |
| REAC:R-HSA-5357956 | 0.00507136546841 | 0.5 | TNF TRADD | TNFR1-induced NF-kappa-B signaling pathway |
| KEGG:04622 | 0.00518715200321 | 0.5 | TNF TRADD | RIG-I-like receptor signaling pathway |
| WP:WP254 | 0.00666804419641 | 0.5 | TNF TRADD | Apoptosis |
| KEGG:04657 | 0.00728891894502 | 0.5 | TNF TRADD | IL-17 signaling pathway |
| KEGG:04064 | 0.00786967207033 | 0.5 | TNF TRADD | NF-kappa B signaling pathway |
| WP:WP231 | 0.00883615359641 | 0.5 | TNF TRADD | TNF alpha signaling pathway |
| REAC:R-HSA-5357905 | 0.00966180252737 | 0.5 | TNF TRADD | Regulation of TNFR1 signaling |
| KEGG:04668 | 0.011104386562 | 0.5 | TNF TRADD | TNF signaling pathway |
| KEGG:04071 | 0.0130545606238 | 0.5 | TNF TRADD | Sphingolipid signaling pathway |
| REAC:R-HSA-75893 | 0.0140623832262 | 0.5 | TNF TRADD | TNF signaling |
| KEGG:04210 | 0.0177164397058 | 0.5 | TNF TRADD | Apoptosis |
| KEGG:04936 | 0.0189154103852 | 0.5 | TNF TRADD | Alcoholic liver disease |
| KEGG:05160 | 0.0211069184789 | 0.5 | TNF TRADD | Hepatitis C |
| KEGG:04217 | 0.0230797254414 | 0.5 | TNF TRADD | Necroptosis |
| KEGG:05164 | 0.0254912281659 | 0.5 | TNF TRADD | Influenza A |
| KEGG:05152 | 0.02620193588 | 0.5 | TNF TRADD | Tuberculosis |
| KEGG:05130 | 0.0334335704012 | 0.5 | TNF TRADD | Pathogenic Escherichia coli infection |
| KEGG:05169 | 0.0397541089323 | 0.5 | TNF TRADD | Epstein-Barr virus infection |
| KEGG:05163 | 0.0451972531521 | 0.5 | TNF TRADD | Human cytomegalovirus infection |
| KEGG:05170 | 0.0456663239038 | 0.5 | TNF TRADD | Human immunodeficiency virus 1 infection |
| CORUM:5540 | 0.049938562206 | 0.25 | TRADD | TRAF2-TRADD complex |
| CORUM:6684 | 0.049938562206 | 0.25 | TNF | TNFR2 signaling complex |
| REAC:R-HSA-4755583 | 0.0499436884912 | 0.25 | DOLK | Defective DOLK causes DOLK-CDG |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TRADD | TNFRSF1A | 0.992 | 0.1 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TNFRSF1A | TNF | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| DOLK | TNFRSF1A | 0.977 | 0.174 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SLC39A1 | TNFRSF1A | 0.977 | 0.138 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| TRADD | TNF | 0.333 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLC39A1 | TNF | 0.187 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLC39A1 | TRADD | 0.165 | 0.054 | bioplex_WMM bioplex3_WMM WMM_only |
| DOLK | TRADD | 0.165 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only |
| DOLK | TNF | 0.165 | bioplex_WMM bioplex3_WMM WMM_only | |
| SLC39A1 | DOLK | 0.116 | 0.128 | bioplex_WMM bioplex3_WMM WMM_only |
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