hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_10997.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MKNK2 | MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2) | 5 | UniProt NCBI |
| MAPK14 | Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a) | 5 | UniProt NCBI |
| DUSP16 | Dual specificity protein phosphatase 16 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7) | 5 | UniProt NCBI |
| MKNK1 | MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) | 5 | UniProt NCBI |
| MAPKAPK3 | MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK) | 5 | UniProt NCBI |
| MAPK11 | Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP382 | 4.50667994303e-10 | 1.0 | MKNK1 DUSP16 MKNK2 MAPK11 MAPK14 MAPKAPK3 | MAPK signaling pathway |
| KEGG:04010 | 1.02865687391e-09 | 1.0 | MKNK1 DUSP16 MKNK2 MAPK11 MAPK14 MAPKAPK3 | MAPK signaling pathway |
| WP:WP2637 | 6.95851215581e-08 | 0.666666666667 | MKNK2 MKNK1 MAPK11 MAPK14 | Interleukin 1 IL 1 structural pathway |
| REAC:R-HSA-171007 | 8.4720413934e-07 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | p38MAPK events |
| REAC:R-HSA-167044 | 2.56826946848e-06 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | Signalling to RAS |
| REAC:R-HSA-450302 | 8.03604834368e-06 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | activated TAK1 mediates p38 MAPK activation |
| REAC:R-HSA-187687 | 1.83108883385e-05 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | Signalling to ERKs |
| KEGG:04370 | 4.11375354214e-05 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | VEGF signaling pathway |
| GO:0009931 | 0.00010757157937 | 0.5 | MKNK2 MAPKAPK3 MKNK1 | calcium-dependent protein serine/threonine kinase activity |
| GO:0010857 | 0.000161332517231 | 0.5 | MKNK2 MAPKAPK3 MKNK1 | calcium-dependent protein kinase activity |
| REAC:R-HSA-450294 | 0.000194320923954 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | MAP kinase activation |
| REAC:R-HSA-448424 | 0.000264877822759 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | Interleukin-17 signaling |
| KEGG:04148 | 0.000605742659033 | 0.5 | MAPK14 DUSP16 MAPK11 | Efferocytosis |
| REAC:R-HSA-975871 | 0.000618329565809 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168176 | 0.000618329565809 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-168142 | 0.000618329565809 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975138 | 0.000665071217307 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-168181 | 0.000689296551176 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-975155 | 0.000689296551176 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-376172 | 0.000722165722116 | 0.333333333333 | MAPK14 MAPK11 | DSCAM interactions |
| REAC:R-HSA-4420097 | 0.00073948978705 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-168138 | 0.000792051133325 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168164 | 0.00084703415394 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-937061 | 0.00090449234483 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.00090449234483 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-2151209 | 0.000928329318648 | 0.333333333333 | MAPK14 MAPK11 | Activation of PPARGC1A (PGC-1alpha) by phosphorylation |
| REAC:R-HSA-166058 | 0.000964479133971 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-194138 | 0.000964479133971 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | Signaling by VEGF |
| REAC:R-HSA-168188 | 0.000964479133971 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-181438 | 0.00102704788141 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-168179 | 0.00102704788141 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-187037 | 0.00102704788141 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-450341 | 0.00116019984728 | 0.333333333333 | MAPK14 MAPK11 | Activation of the AP-1 family of transcription factors |
| REAC:R-HSA-2559580 | 0.00138048384488 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | Oxidative Stress Induced Senescence |
| REAC:R-HSA-166520 | 0.00167064168535 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | Signaling by NTRKs |
| GO:0004674 | 0.001703068938 | 0.833333333333 | MKNK2 MKNK1 MAPK11 MAPKAPK3 MAPK14 | protein serine/threonine kinase activity |
| WP:WP4767 | 0.00171766688832 | 0.333333333333 | MAPK14 MAPK11 | FGFR3 signaling in chondrocyte proliferation and terminal differentiation |
| WP:WP5272 | 0.00171766688832 | 0.333333333333 | MAPK14 MAPK11 | LDL influence on CD14 and TLR4 |
| WP:WP4864 | 0.00190817031826 | 0.333333333333 | MAPK14 MAPK11 | Host pathogen interaction of human coronaviruses apoptosis |
| REAC:R-HSA-9006934 | 0.00198049991413 | 0.666666666667 | MAPK14 MAPK11 MAPKAPK3 MKNK1 | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-166016 | 0.00209955523641 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | Toll Like Receptor 4 (TLR4) Cascade |
| WP:WP3879 | 0.00210864528598 | 0.333333333333 | MKNK2 MKNK1 | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression |
| WP:WP1528 | 0.00210864528598 | 0.333333333333 | MAPK14 MAPK11 | Physiological and pathological hypertrophy of the heart |
| WP:WP3612 | 0.0023190863075 | 0.333333333333 | MAPK14 MAPK11 | Photodynamic therapy induced NFE2L2 NRF2 survival signaling |
| GO:0051019 | 0.00254971303757 | 0.5 | MAPK14 DUSP16 MAPKAPK3 | mitogen-activated protein kinase binding |
| GO:0004683 | 0.00295184433846 | 0.5 | MKNK2 MAPKAPK3 MKNK1 | calmodulin-dependent protein kinase activity |
| WP:WP3869 | 0.00301015088032 | 0.333333333333 | MAPK14 MAPK11 | Cannabinoid receptor signaling |
| REAC:R-HSA-168898 | 0.00323172543915 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | Toll-like Receptor Cascades |
| WP:WP722 | 0.00326040131097 | 0.333333333333 | MAPK14 MAPKAPK3 | Serotonin HTR1 group and FOS pathway |
| REAC:R-HSA-450604 | 0.0035019037522 | 0.333333333333 | MAPK14 MAPK11 | KSRP (KHSRP) binds and destabilizes mRNA |
| WP:WP2643 | 0.00352059040085 | 0.333333333333 | MAPK14 MAPK11 | Nanoparticle mediated activation of receptor signaling |
| WP:WP4877 | 0.00436073489596 | 0.333333333333 | MAPK14 MAPK11 | Host pathogen interaction of human coronaviruses MAPK signaling |
| WP:WP400 | 0.00436073489596 | 0.333333333333 | MAPK14 MKNK1 | p38 MAPK signaling pathway |
| REAC:R-HSA-198753 | 0.00540340354533 | 0.333333333333 | MAPK14 MAPK11 | ERK/MAPK targets |
| REAC:R-HSA-5668599 | 0.00540340354533 | 0.333333333333 | MAPK14 MAPK11 | RHO GTPases Activate NADPH Oxidases |
| WP:WP2371 | 0.00561973689916 | 0.333333333333 | MAPK14 MAPK11 | Parkinson 39 s disease pathway |
| REAC:R-HSA-2559583 | 0.00604240808777 | 0.5 | MAPK14 MAPKAPK3 MAPK11 | Cellular Senescence |
| GO:0004672 | 0.00707737205009 | 0.833333333333 | MKNK2 MKNK1 MAPK11 MAPKAPK3 MAPK14 | protein kinase activity |
| REAC:R-HSA-525793 | 0.0070977267476 | 0.333333333333 | MAPK14 MAPK11 | Myogenesis |
| WP:WP3611 | 0.00903081201495 | 0.333333333333 | MAPK14 MAPK11 | Photodynamic therapy induced AP 1 survival signaling |
| KEGG:04664 | 0.00992545203512 | 0.333333333333 | MAPK14 MAPK11 | Fc epsilon RI signaling pathway |
| WP:WP395 | 0.0108030732892 | 0.333333333333 | MAPK14 MAPK11 | IL 4 signaling pathway |
| REAC:R-HSA-450282 | 0.0111743831709 | 0.333333333333 | MAPK14 MAPK11 | MAPK targets/ Nuclear events mediated by MAP kinases |
| KEGG:05133 | 0.0123104747863 | 0.333333333333 | MAPK14 MAPK11 | Pertussis |
| REAC:R-HSA-168638 | 0.0127367120473 | 0.333333333333 | MAPK14 MAPK11 | NOD1/2 Signaling Pathway |
| KEGG:04917 | 0.0135980974704 | 0.333333333333 | MAPK14 MAPK11 | Prolactin signaling pathway |
| KEGG:05140 | 0.0135980974704 | 0.333333333333 | MAPK14 MAPK11 | Leishmaniasis |
| KEGG:05120 | 0.0140413695312 | 0.333333333333 | MAPK14 MAPK11 | Epithelial cell signaling in Helicobacter pylori infection |
| WP:WP3865 | 0.0142825477425 | 0.333333333333 | MAPK14 MAPK11 | Novel intracellular components of RIG I like receptor pathway |
| KEGG:04622 | 0.0149489869659 | 0.333333333333 | MAPK14 MAPK11 | RIG-I-like receptor signaling pathway |
| KEGG:04912 | 0.0163630378499 | 0.333333333333 | MAPK14 MAPK11 | GnRH signaling pathway |
| KEGG:04750 | 0.0168484058015 | 0.333333333333 | MAPK14 MAPK11 | Inflammatory mediator regulation of TRP channels |
| REAC:R-HSA-373752 | 0.0170865043842 | 0.333333333333 | MAPK14 MAPK11 | Netrin-1 signaling |
| WP:WP4538 | 0.0176466803728 | 0.333333333333 | MAPK14 MAPK11 | Regulatory circuits of the STAT3 signaling pathway |
| GO:0016773 | 0.018781111661 | 0.833333333333 | MKNK2 MKNK1 MAPK11 MAPKAPK3 MAPK14 | phosphotransferase activity, alcohol group as acceptor |
| KEGG:04658 | 0.0193802025824 | 0.333333333333 | MAPK14 MAPK11 | Th1 and Th2 cell differentiation |
| WP:WP3303 | 0.019460492062 | 0.333333333333 | MAPK14 MAPK11 | RAC1 PAK1 p38 MMP2 pathway |
| WP:WP4341 | 0.019460492062 | 0.333333333333 | MAPK14 MAPK11 | Non genomic actions of 1 25 dihydroxyvitamin D3 |
| KEGG:04657 | 0.0209831060756 | 0.333333333333 | MAPK14 MAPK11 | IL-17 signaling pathway |
| WP:WP5087 | 0.0221664611486 | 0.5 | MKNK2 MKNK1 MAPK14 | Pleural mesothelioma |
| KEGG:05235 | 0.0226487502466 | 0.333333333333 | MAPK14 MAPK11 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| WP:WP4746 | 0.0226781844519 | 0.333333333333 | MAPK14 MAPKAPK3 | Thyroid hormones production and peripheral downstream signaling effects |
| KEGG:04914 | 0.0237939838034 | 0.333333333333 | MAPK14 MAPK11 | Progesterone-mediated oocyte maturation |
| KEGG:01522 | 0.0237939838034 | 0.333333333333 | MAPK14 MAPK11 | Endocrine resistance |
| KEGG:04625 | 0.0255639626352 | 0.333333333333 | MAPK14 MAPK11 | C-type lectin receptor signaling pathway |
| KEGG:04670 | 0.0261678409889 | 0.333333333333 | MAPK14 MAPK11 | Leukocyte transendothelial migration |
| REAC:R-HSA-168643 | 0.0265097243254 | 0.333333333333 | MAPK14 MAPK11 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| GO:0016301 | 0.0266728271518 | 0.833333333333 | MKNK2 MKNK1 MAPK11 MAPKAPK3 MAPK14 | kinase activity |
| KEGG:04933 | 0.0267786555833 | 0.333333333333 | MAPK14 MAPK11 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:04620 | 0.0267786555833 | 0.333333333333 | MAPK14 MAPK11 | Toll-like receptor signaling pathway |
| KEGG:05142 | 0.0273964025417 | 0.333333333333 | MAPK14 MAPK11 | Chagas disease |
| KEGG:04659 | 0.0286526780492 | 0.333333333333 | MAPK14 MAPK11 | Th17 cell differentiation |
| KEGG:05145 | 0.029291198851 | 0.333333333333 | MAPK14 MAPK11 | Toxoplasmosis |
| KEGG:04668 | 0.0319144120476 | 0.333333333333 | MAPK14 MAPK11 | TNF signaling pathway |
| WP:WP75 | 0.0337850948883 | 0.333333333333 | MAPK14 MAPK11 | Toll like receptor signaling pathway |
| KEGG:04611 | 0.0339543001219 | 0.333333333333 | MAPK14 MAPK11 | Platelet activation |
| KEGG:04066 | 0.034648047564 | 0.333333333333 | MKNK2 MKNK1 | HIF-1 signaling pathway |
| KEGG:04722 | 0.0353486809432 | 0.333333333333 | MAPK14 MAPK11 | Neurotrophin signaling pathway |
| KEGG:04935 | 0.0353486809432 | 0.333333333333 | MAPK14 MAPK11 | Growth hormone synthesis, secretion and action |
| REAC:R-HSA-198725 | 0.03659902859 | 0.333333333333 | MAPK14 MAPK11 | Nuclear Events (kinase and transcription factor activation) |
| KEGG:04660 | 0.0374918580993 | 0.333333333333 | MAPK14 MAPK11 | T cell receptor signaling pathway |
| KEGG:04071 | 0.0374918580993 | 0.333333333333 | MAPK14 MAPK11 | Sphingolipid signaling pathway |
| KEGG:04114 | 0.0382199966286 | 0.333333333333 | MAPK14 MAPK11 | Oocyte meiosis |
| WP:WP4321 | 0.0405958365711 | 0.333333333333 | MAPK14 MAPK11 | Thermogenesis |
| KEGG:04926 | 0.0412011786405 | 0.333333333333 | MAPK14 MAPK11 | Relaxin signaling pathway |
| KEGG:04728 | 0.0419636118509 | 0.333333333333 | MAPK14 MAPK11 | Dopaminergic synapse |
| KEGG:04068 | 0.045081780015 | 0.333333333333 | MAPK14 MAPK11 | FoxO signaling pathway |
| KEGG:04380 | 0.0466818714337 | 0.333333333333 | MAPK14 MAPK11 | Osteoclast differentiation |
| KEGG:05135 | 0.0466818714337 | 0.333333333333 | MAPK14 MAPK11 | Yersinia infection |
| WP:WP5322 | 0.0480201060929 | 0.333333333333 | MAPK14 MAPKAPK3 | CKAP4 signaling pathway map |
| KEGG:05418 | 0.0483092600715 | 0.333333333333 | MAPK14 MAPK11 | Fluid shear stress and atherosclerosis |
| REAC:R-HSA-162582 | 0.0495022563739 | 0.833333333333 | MAPK14 MAPK11 MAPKAPK3 DUSP16 MKNK1 | Signal Transduction |
| KEGG:04261 | 0.0499639151988 | 0.333333333333 | MAPK14 MAPK11 | Adrenergic signaling in cardiomyocytes |
| KEGG:04723 | 0.0499639151988 | 0.333333333333 | MAPK14 MAPK11 | Retrograde endocannabinoid signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAPKAPK3 | MAPK14 | 1.0 | 0.286 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| MAPK14 | MKNK1 | 0.999 | 0.154 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MAPKAPK3 | MAPK11 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MAPK14 | DUSP16 | 0.986 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MKNK2 | MAPK14 | 0.975 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MAPK11 | MAPK14 | 0.964 | bioplex_WMM bioplex3_WMM WMM_only | |
| MAPKAPK3 | MKNK1 | 0.884 | 0.224 | bioplex_WMM bioplex3_WMM WMM_only |
| MKNK2 | MKNK1 | 0.551 | bioplex_WMM bioplex3_WMM WMM_only | |
| MKNK2 | MAPKAPK3 | 0.513 | bioplex_WMM bioplex3_WMM WMM_only | |
| MKNK2 | DUSP16 | 0.498 | bioplex_WMM bioplex3_WMM WMM_only | |
| MAPKAPK3 | DUSP16 | 0.378 | bioplex_WMM bioplex3_WMM WMM_only | |
| DUSP16 | MKNK1 | 0.214 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes