hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11006.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ADAMTS14 | A disintegrin and metalloproteinase with thrombospondin motifs 14 (ADAM-TS 14) (ADAM-TS14) (ADAMTS-14) (EC 3.4.24.-) | 5 | UniProt NCBI |
| INSR | Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta] | 5 | UniProt NCBI |
| PLXND1 | Plexin-D1 | 5 | UniProt NCBI |
| IGF1R | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] | 5 | UniProt NCBI |
| HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 (11-DH) (11-beta-HSD1) (EC 1.1.1.146) (7-oxosteroid reductase) (EC 1.1.1.201) (Corticosteroid 11-beta-dehydrogenase isozyme 1) (Short chain dehydrogenase/reductase family 26C member 1) | 5 | UniProt NCBI |
| DNASE1L1 | Deoxyribonuclease-1-like 1 (EC 3.1.21.-) (DNase X) (Deoxyribonuclease I-like 1) (DNase I-like 1) (Muscle-specific DNase I-like) (XIB) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5385 | 0.00161852668418 | 0.4 | INSR IGF1R | Growth factors and hormones in Beta cell proliferation |
| KEGG:04913 | 0.0028504483789 | 0.4 | INSR IGF1R | Ovarian steroidogenesis |
| KEGG:04213 | 0.00645863473927 | 0.4 | INSR IGF1R | Longevity regulating pathway - multiple species |
| GO:0005009 | 0.0140440992017 | 0.4 | INSR IGF1R | insulin receptor activity |
| KEGG:04211 | 0.0145692619713 | 0.4 | INSR IGF1R | Longevity regulating pathway |
| KEGG:04520 | 0.0164241113683 | 0.4 | INSR IGF1R | Adherens junction |
| WP:WP4540 | 0.019320838505 | 0.4 | INSR IGF1R | Hippo signaling regulation pathways |
| HP:0000178 | 0.0207498058008 | 0.6 | INSR PLXND1 IGF1R | Abnormal lower lip morphology |
| KEGG:04066 | 0.0217595858915 | 0.4 | INSR IGF1R | HIF-1 signaling pathway |
| HP:0003758 | 0.0224351839587 | 0.4 | INSR IGF1R | Reduced subcutaneous adipose tissue |
| WP:WP4541 | 0.0264781270697 | 0.4 | INSR IGF1R | Hippo Merlin signaling dysregulation |
| GO:0043559 | 0.0280843539964 | 0.4 | INSR IGF1R | insulin binding |
| GO:0005899 | 0.0280843539964 | 0.4 | INSR IGF1R | insulin receptor complex |
| KEGG:04068 | 0.028330266578 | 0.4 | INSR IGF1R | FoxO signaling pathway |
| KEGG:04152 | 0.028330266578 | 0.4 | INSR IGF1R | AMPK signaling pathway |
| KEGG:04150 | 0.0484667159694 | 0.4 | INSR IGF1R | mTOR signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ADAMTS14 | DNASE1L1 | 0.999 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PLXND1 | DNASE1L1 | 0.998 | 0.108 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| IGF1R | INSR | 0.988 | 0.15 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM |
| IGF1R | DNASE1L1 | 0.979 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| INSR | DNASE1L1 | 0.962 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| HSD11B1 | INSR | 0.957 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| IGF1R | ADAMTS14 | 0.631 | bioplex3_WMM WMM_only | |
| PLXND1 | IGF1R | 0.561 | 0.06 | bioplex3_WMM WMM_only |
| PLXND1 | INSR | 0.55 | 0.204 | bioplex3_WMM WMM_only |
| HSD11B1 | IGF1R | 0.494 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| INSR | ADAMTS14 | 0.468 | bioplex3_WMM WMM_only | |
| PLXND1 | ADAMTS14 | 0.255 | bioplex3_WMM WMM_only |
Related Complexes