hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11009.1
Complex Portal: CPX-15954
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RFLNB | Refilin-B (Regulator of filamin protein B) (RefilinB) | 3 | UniProt NCBI |
| SHB | SH2 domain-containing adapter protein B | 5 | UniProt NCBI |
| ALMS1 | Centrosome-associated protein ALMS1 (Alstrom syndrome protein 1) | 5 | UniProt NCBI |
| FBLIM1 | Filamin-binding LIM protein 1 (FBLP-1) (Migfilin) (Mitogen-inducible 2-interacting protein) (MIG2-interacting protein) | 5 | UniProt NCBI |
| CBL | E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL) | 5 | UniProt NCBI |
| CUTA | Protein CutA (Acetylcholinesterase-associated protein) (Brain acetylcholinesterase putative membrane anchor) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0012569 | 0.0226111656051 | 0.333333333333 | ALMS1 CBL | Delayed menarche |
| CORUM:5713 | 0.0499436884912 | 0.166666666667 | CBL | SH3P2/OSTF1-CBL-SRC complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FBLIM1 | CUTA | 0.999 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| FBLIM1 | SHB | 0.998 | 0.078 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RFLNB | FBLIM1 | 0.994 | 0.088 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FBLIM1 | CBL | 0.981 | 0.05 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FBLIM1 | ALMS1 | 0.966 | 0.112 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SHB | CBL | 0.953 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| SHB | CUTA | 0.915 | 0.068 | bioplex3_WMM WMM_only | |
| RFLNB | CUTA | 0.9 | 0.032 | bioplex3_WMM WMM_only | |
| RFLNB | SHB | 0.757 | 0.056 | bioplex3_WMM WMM_only | |
| CBL | CUTA | 0.673 | 0.036 | bioplex3_WMM WMM_only | |
| SHB | ALMS1 | 0.618 | 0.14 | bioplex3_WMM WMM_only | |
| RFLNB | CBL | 0.568 | 0.142 | bioplex3_WMM youn_WMM WMM_only | |
| CUTA | ALMS1 | 0.403 | 0.052 | bioplex3_WMM WMM_only | |
| CBL | ALMS1 | 0.185 | 0.244 | bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| RFLNB | ALMS1 | 0.14 | 0.136 | bioplex3_WMM youn_WMM WMM_only |
Related Complexes