hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11011.1
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CRTAP | Cartilage-associated protein | 5 | UniProt NCBI |
| P3H2 | Prolyl 3-hydroxylase 2 (EC 1.14.11.7) (Leprecan-like protein 1) (Myxoid liposarcoma-associated protein 4) | 5 | UniProt NCBI |
| CPSF7 | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | 5 | UniProt NCBI |
| NUDT21 | Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Nudix hydrolase 21) (Pre-mRNA cleavage factor Im 68 kDa subunit) | 5 | UniProt NCBI |
| CPSF6 | Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7) | 5 | UniProt NCBI |
| KIAA1217 | Sickle tail protein homolog | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1141 | 1.33567017806e-06 | 0.5 | CPSF6 CPSF7 NUDT21 | CF IIAm complex (Cleavage factor IIAm complex) |
| GO:1990120 | 1.92240082153e-06 | 0.5 | CPSF6 CPSF7 NUDT21 | messenger ribonucleoprotein complex assembly |
| GO:0110104 | 7.68841921772e-06 | 0.5 | CPSF6 CPSF7 NUDT21 | mRNA alternative polyadenylation |
| CORUM:1769 | 5.12534978153e-05 | 0.333333333333 | NUDT21 CPSF6 | CPSF6-ITCH-NUDT21-POLR2A complex |
| CORUM:1767 | 0.000102488289015 | 0.333333333333 | NUDT21 CPSF6 | CPSF6-ITCH-NUDT21-POLR2A-UBAP2L complex |
| CORUM:1768 | 0.000170782642132 | 0.333333333333 | NUDT21 CPSF6 | CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex |
| KEGG:03015 | 0.000238502370467 | 0.5 | CPSF6 CPSF7 NUDT21 | mRNA surveillance pathway |
| GO:0051290 | 0.000316805542726 | 0.5 | CPSF6 CPSF7 NUDT21 | protein heterotetramerization |
| GO:0051291 | 0.0010743908712 | 0.5 | CPSF6 CPSF7 NUDT21 | protein heterooligomerization |
| GO:0005847 | 0.00130441648129 | 0.5 | CPSF6 CPSF7 NUDT21 | mRNA cleavage and polyadenylation specificity factor complex |
| GO:0005849 | 0.00254971303757 | 0.5 | CPSF6 CPSF7 NUDT21 | mRNA cleavage factor complex |
| REAC:R-HSA-77595 | 0.00440152140132 | 0.333333333333 | CPSF7 NUDT21 | Processing of Intronless Pre-mRNAs |
| WP:WP4786 | 0.0046606239013 | 0.333333333333 | P3H2 CRTAP | Type I collagen synthesis in the context of osteogenesis imperfecta |
| REAC:R-HSA-75067 | 0.00902151290218 | 0.333333333333 | CPSF7 NUDT21 | Processing of Capped Intronless Pre-mRNA |
| KEGG:03250 | 0.0114872599973 | 0.333333333333 | CPSF7 CPSF6 | Viral life cycle - HIV-1 |
| GO:0031124 | 0.0219369042126 | 0.5 | CPSF6 CPSF7 NUDT21 | mRNA 3'-end processing |
| REAC:R-HSA-1650814 | 0.0339259639772 | 0.333333333333 | P3H2 CRTAP | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-72187 | 0.0379731829042 | 0.333333333333 | CPSF7 NUDT21 | mRNA 3'-end processing |
| HPA:0130053 | 0.0402861370309 | 0.833333333333 | CPSF6 P3H2 KIAA1217 CRTAP CPSF7 | colon; glandular cells[High] |
| REAC:R-HSA-73856 | 0.0498675109087 | 0.333333333333 | CPSF7 NUDT21 | RNA Polymerase II Transcription Termination |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NUDT21 | CPSF6 | 1.0 | 0.892 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| CPSF7 | CPSF6 | 1.0 | 0.706 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| CRTAP | P3H2 | 0.998 | 0.062 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| CPSF7 | NUDT21 | 0.992 | 0.706 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction boldt_WMM treiber_WMM |
| CPSF7 | KIAA1217 | 0.979 | 0.034 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| CPSF6 | CRTAP | 0.977 | 0.094 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM WMM_only |
| NUDT21 | P3H2 | 0.972 | 0.018 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| NUDT21 | CRTAP | 0.961 | 0.088 | hein_WMM bioplex_WMM bioplex3_WMM hein () treiber_WMM |
| CPSF7 | CRTAP | 0.867 | 0.06 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only treiber_WMM |
| CPSF6 | P3H2 | 0.759 | 0.022 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| CPSF7 | P3H2 | 0.211 | 0.03 | hein_WMM bioplex3_WMM WMM_only |
| KIAA1217 | CPSF6 | 0.005 | 0.108 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| KIAA1217 | NUDT21 | 0.002 | 0.116 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| KIAA1217 | CRTAP | 0.001 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes