hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_11013.1
Complex Portal: CPX-16599
Confidence: Medium High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HIPK2 | Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1) | 5 | UniProt NCBI |
| DCAF7 | DDB1- and CUL4-associated factor 7 (WD repeat-containing protein 68) (WD repeat-containing protein An11 homolog) | 5 | UniProt NCBI |
| C16orf95 | Uncharacterized protein C16orf95 | 1 | UniProt NCBI |
| SOWAHB | Ankyrin repeat domain-containing protein SOWAHB (Ankyrin repeat domain-containing protein 56) (Protein sosondowah homolog B) | 3 | UniProt NCBI |
| SOWAHA | Ankyrin repeat domain-containing protein SOWAHA (Ankyrin repeat domain-containing protein 43) (Protein sosondowah homolog A) | 3 | UniProt NCBI |
| DIAPH2 | Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) | 5 | UniProt NCBI |
| ZNF703 | Zinc finger protein 703 (Zinc finger elbow-related proline domain protein 1) | 5 | UniProt NCBI |
| ZNF503 | Zinc finger protein 503 | 5 | UniProt NCBI |
| SOWAHC | Ankyrin repeat domain-containing protein SOWAHC (Ankyrin repeat domain-containing protein 57) (Protein sosondowah homolog C) | 2 | UniProt NCBI |
| RHOD | Rho-related GTP-binding protein RhoD (Rho-related protein HP1) (RhoHP1) | 5 | UniProt NCBI |
| DIAPH1 | Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9035034 | 0.000928373078657 | 0.272727272727 | DIAPH2 DIAPH1 SOWAHC | RHOF GTPase cycle |
| REAC:R-HSA-9012999 | 0.0382659460337 | 0.363636363636 | DIAPH2 RHOD DIAPH1 SOWAHC | RHO GTPase cycle |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DCAF7 | SOWAHC | 0.998 | 0.072 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| RHOD | DIAPH2 | 0.996 | 0.210333333333 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only |
| DCAF7 | ZNF703 | 0.996 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM | |
| ZNF703 | ZNF503 | 0.991 |
mutually_exclusive (P61962)
|
bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| SOWAHB | DIAPH2 | 0.991 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| RHOD | DIAPH1 | 0.99 | 0.416 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| HIPK2 | DCAF7 | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SOWAHC | DIAPH1 | 0.98 | 0.128 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM | |
| DCAF7 | ZNF503 | 0.98 | 0.112 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM |
| SOWAHB | DIAPH1 | 0.972 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| DCAF7 | C16orf95 | 0.968 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| DCAF7 | DIAPH1 | 0.965 | 0.04 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| DCAF7 | SOWAHB | 0.956 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SOWAHC | SOWAHB | 0.908 |
mutually_exclusive (P61962)
|
bioplex3_WMM WMM_only | |
| HIPK2 | SOWAHB | 0.904 | bioplex3_WMM WMM_only | ||
| HIPK2 | SOWAHC | 0.902 | bioplex3_WMM WMM_only | ||
| ZNF703 | SOWAHC | 0.819 |
mutually_exclusive (P61962)
|
bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| SOWAHC | ZNF503 | 0.76 | 0.064 |
mutually_exclusive (P61962)
|
bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| ZNF503 | DIAPH1 | 0.732 | 0.11 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| ZNF503 | SOWAHB | 0.675 |
mutually_exclusive (P61962)
|
bioplex3_WMM WMM_only | |
| ZNF703 | SOWAHB | 0.652 |
mutually_exclusive (P61962)
|
bioplex3_WMM WMM_only | |
| HIPK2 | ZNF503 | 0.631 | bioplex3_WMM WMM_only | ||
| HIPK2 | DIAPH1 | 0.63 | bioplex3_WMM WMM_only | ||
| C16orf95 | SOWAHC | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | ||
| HIPK2 | ZNF703 | 0.545 | bioplex3_WMM WMM_only | ||
| DIAPH1 | DIAPH2 | 0.407 | 0.164 | bioplex3_WMM youn_WMM WMM_only | |
| C16orf95 | DIAPH1 | 0.336 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ZNF703 | DIAPH1 | 0.289 | bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | ||
| HIPK2 | C16orf95 | 0.214 | bioplex3_WMM WMM_only | ||
| C16orf95 | SOWAHB | 0.214 | bioplex3_WMM WMM_only | ||
| C16orf95 | ZNF703 | 0.16 | bioplex_WMM bioplex3_WMM WMM_only | ||
| C16orf95 | ZNF503 | 0.15 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SOWAHC | RHOD | 0.043 | 0.178 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SOWAHC | DIAPH2 | 0.018 | 0.102 | bioplex3_WMM WMM_only | |
| DCAF7 | DIAPH2 | 0.011 | 0.066 | bioplex3_WMM youn_WMM WMM_only |
Related Complexes